公开(公告)号：US20250122184A1

公开(公告)日：2025-04-17

申请号：US18985661

申请日：2024-12-18

Applicant: Genentech, Inc.

Inventor： Jack Alexander TERRETT ,  Huifen CHEN ,  Lea CONSTANTINEAU-FORGET ,  Robin Larouche-Gauthier ,  Luce LÉPISSIER ,  Francis BEAUMIER ,  Martin DÉRY ,  Chantal GRAND-MAÎTRE ,  Claudio STURINO ,  Matthew VOLGRAF ,  Elisia VILLEMURE

IPC: C07D413/14 ,  A61K31/427 ,  A61P11/00 ,  A61P23/00 ,  A61P25/00 ,  A61P29/00 ,  C07D471/04 ,  C07D473/30 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US20240383915A1

公开(公告)日：2024-11-21

申请号：US18554438

申请日：2022-04-06

Applicant: Genentech, Inc.

Inventor： Lewis J. GAZZARD ,  Samantha Alyson GREEN ,  Elizabeth H. KELLEY ,  Matthew Leo LANDRY ,  Sushant MALHOTRA ,  Benjamin David RAVETZ ,  Michael SIU ,  Jack Alexander TERRETT ,  BinQing WEI ,  Steven DO ,  Yun-Xing CHENG ,  Limin CHENG ,  Jianfeng XIN ,  Mingtao HE ,  Guosheng WU ,  Yinlei SUN ,  Cheng SHAO ,  Aijun LU ,  Yulai ZHANG

IPC: C07D498/04 ,  A61K31/553 ,  A61K45/06 ,  C07D519/00

Abstract: Provided herein are acyclic oxazepinyl compounds useful in the treatment on cancers.

公开(公告)号：US20240228512A1

公开(公告)日：2024-07-11

申请号：US18490736

申请日：2023-10-19

Applicant: Genentech, Inc.

Inventor： Benjamin David RAVETZ ,  Jack Alexander TERRETT ,  BinQing WEI ,  Mingshuo ZENG ,  Cheng SHAO ,  Yinlei SUN

IPC: C07D519/00 ,  A61K31/553 ,  A61P31/00 ,  C07D498/16

CPC classification number: C07D519/00 ,  A61K31/553 ,  A61P31/00 ,  C07D498/16

Abstract: Provided herein are acyclic oxazepinyl compounds comprising a 6-aza moiety that are useful in the treatment of cancers.

公开(公告)号：US20230121700A1

公开(公告)日：2023-04-20

申请号：US17816855

申请日：2022-08-02

Applicant: Genentech, Inc.

Inventor： Jack Alexander TERRETT ,  Huifen CHEN ,  Lea CONSTANTINEAU-FORGET ,  Robin Larouche-Gauthier ,  Luce LÉPISSIER ,  Francis BEAUMIER ,  Martin DÉRY ,  Chantal GRAND-MAÎTRE ,  Claudio STURINO ,  Matthew VOLGRAF ,  Elisia VILLEMURE

IPC: C07D413/14 ,  C07D473/30 ,  C07D471/04 ,  A61P29/00 ,  C07D513/04 ,  C07D487/04 ,  A61P25/00 ,  C07D498/04 ,  A61K31/427 ,  A61P23/00 ,  A61P11/00

Abstract: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.