公开(公告)号：US12187709B2

公开(公告)日：2025-01-07

申请号：US18052851

申请日：2022-11-04

Applicant: Genentech, Inc.

Inventor： Malcolm Huestis ,  Michael John Lambrecht ,  Jun Liang ,  Man Un Ung ,  Xiaojing Wang ,  Jason Robert Zbieg ,  Bing-Yan Zhu ,  Lisa Marie Barton ,  Fabio Broccatelli ,  Georgette Marie Castanedo ,  Araz Jakalian ,  Robin Larouche-Gauthier ,  Arun Yadav

IPC: C07D403/12 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D493/08

Abstract: A compound, of formula (I): suitable for treating a cancer wherein the cancer is susceptible to inhibition of Cbl-B.

公开(公告)号：US20230202984A1

公开(公告)日：2023-06-29

申请号：US18057738

申请日：2022-11-21

Applicant: Genentech, Inc.

Inventor： Jason Robert Zbieg ,  Russell Tyler Smith ,  Paul Powell Beroza ,  Vishal Anil Verma ,  Bing-Yan Zhu ,  Ramsay Beveridge ,  Lisa Marie Barton ,  Bryan Ka lp Chan ,  Curtis Colwell ,  Samir Bouayad-Gervais ,  Anwesha Dey ,  Marie Anne Evangelista

IPC: C07D231/56 ,  C07D471/04 ,  C07F9/09

CPC classification number: C07D231/56 ,  C07D471/04 ,  C07F9/095

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US12275745B2

公开(公告)日：2025-04-15

申请号：US18057742

申请日：2022-11-21

Applicant: Genentech, Inc.

Inventor： Jason Robert Zbieg ,  Paul Powell Beroza ,  Vishal Anil Verma ,  Bing-Yan Zhu ,  Ramsay Beveridge ,  Liang Zhao ,  Melissa Leblanc ,  Lisa Marie Barton ,  Bryan Ka Ip Chan ,  Samir Bouayad-Gervais ,  Anwesha Dey ,  Marie Anne Evangelista ,  Russell Tyler Smith

IPC: C07D513/04 ,  C07D215/12 ,  C07D235/14 ,  C07D239/74 ,  C07D241/42 ,  C07D263/56 ,  C07D307/81 ,  C07D403/06 ,  C07D405/08 ,  C07D413/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D491/052 ,  C07D498/04

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US12110276B2

公开(公告)日：2024-10-08

申请号：US18057738

申请日：2022-11-21

Applicant: Genentech, Inc.

Inventor： Jason Robert Zbieg ,  Russell Tyler Smith ,  Paul Powell Beroza ,  Vishal Anil Verma ,  Bing-Yan Zhu ,  Ramsay Beveridge ,  Lisa Marie Barton ,  Bryan Ka Ip Chan ,  Curtis Colwell ,  Samir Bouayad-Gervais ,  Anwesha Dey ,  Marie Anne Evangelista

IPC: C07D231/56 ,  C07D471/04 ,  C07F9/09

CPC classification number: C07D231/56 ,  C07D471/04 ,  C07F9/095

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.