公开(公告)号：US20210238184A1

公开(公告)日：2021-08-05

申请号：US17105088

申请日：2020-11-25

Applicant: Genentech, Inc.

Inventor： Jason Robert Zbieg ,  Paul Powell Beroza ,  James John Crawford

IPC: C07D487/04

Abstract: The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R3 have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of the YAP:TEAD protein:protein interaction. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various YAP:TEAD-mediated disorders, including cancer.

公开(公告)号：US20230202984A1

公开(公告)日：2023-06-29

申请号：US18057738

申请日：2022-11-21

Applicant: Genentech, Inc.

Inventor： Jason Robert Zbieg ,  Russell Tyler Smith ,  Paul Powell Beroza ,  Vishal Anil Verma ,  Bing-Yan Zhu ,  Ramsay Beveridge ,  Lisa Marie Barton ,  Bryan Ka lp Chan ,  Curtis Colwell ,  Samir Bouayad-Gervais ,  Anwesha Dey ,  Marie Anne Evangelista

IPC: C07D231/56 ,  C07D471/04 ,  C07F9/09

CPC classification number: C07D231/56 ,  C07D471/04 ,  C07F9/095

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US12110276B2

公开(公告)日：2024-10-08

申请号：US18057738

申请日：2022-11-21

Applicant: Genentech, Inc.

Inventor： Jason Robert Zbieg ,  Russell Tyler Smith ,  Paul Powell Beroza ,  Vishal Anil Verma ,  Bing-Yan Zhu ,  Ramsay Beveridge ,  Lisa Marie Barton ,  Bryan Ka Ip Chan ,  Curtis Colwell ,  Samir Bouayad-Gervais ,  Anwesha Dey ,  Marie Anne Evangelista

IPC: C07D231/56 ,  C07D471/04 ,  C07F9/09

CPC classification number: C07D231/56 ,  C07D471/04 ,  C07F9/095

Abstract: This disclosure relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US20220281819A1

公开(公告)日：2022-09-08

申请号：US17743408

申请日：2022-05-12

Applicant: Genentech, Inc.

Inventor： Jason Robert Zbieg ,  James John Crawford ,  Christian N. Cunningham

IPC: C07D213/75 ,  C07D237/14 ,  C07D213/84 ,  C07C233/27 ,  C07D307/79 ,  C07D239/47 ,  C07D213/74 ,  C07D471/04 ,  C07D263/56 ,  C07D405/06 ,  C07D407/12 ,  C07D277/64

Abstract: The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.

公开(公告)号：US12187709B2

公开(公告)日：2025-01-07

申请号：US18052851

申请日：2022-11-04

Applicant: Genentech, Inc.

Inventor： Malcolm Huestis ,  Michael John Lambrecht ,  Jun Liang ,  Man Un Ung ,  Xiaojing Wang ,  Jason Robert Zbieg ,  Bing-Yan Zhu ,  Lisa Marie Barton ,  Fabio Broccatelli ,  Georgette Marie Castanedo ,  Araz Jakalian ,  Robin Larouche-Gauthier ,  Arun Yadav

IPC: C07D403/12 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D493/08

Abstract: A compound, of formula (I): suitable for treating a cancer wherein the cancer is susceptible to inhibition of Cbl-B.

公开(公告)号：US20240300927A1

公开(公告)日：2024-09-12

申请号：US18275655

申请日：2022-02-03

Applicant: Genentech, Inc.

Inventor： Jun Liang ,  Araz Jakalian ,  Michael John Lambrecht ,  Robin Larouche-Gauthier ,  Malcolm Huestis ,  Man Un Ung ,  Xiaojing Wang ,  Arun Yadav ,  Jason Robert Zbieg ,  Fabio Broccatelli

IPC: C07D405/14 ,  A61K31/4439

CPC classification number: C07D405/14 ,  A61K31/4439

Abstract: Various amide compounds that bind Cbl-B, including those that are selective for C-Cbl, and methods of making and using the same. Representative amide compounds include molecules falling within the following formulae:

公开(公告)号：US20230002396A1

公开(公告)日：2023-01-05

申请号：US17826102

申请日：2022-05-26

Applicant: Genentech, Inc.

Inventor： James John Crawford ,  Jason Robert Zbieg

IPC: C07D487/04 ,  A61P35/00

Abstract: The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, and compositions and uses thereof. The compounds are useful as inhibitors of the YAP:TEAD protein:protein interaction. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various YAP:TEAD-mediated disorders, including cancer.