公开(公告)号：US09393327B2

公开(公告)日：2016-07-19

申请号：US14132252

申请日：2013-12-18

Applicant: Genentech, Inc.

Inventor： Charles Andrew Boswell ,  Leslie A Khawli ,  Jan Marik ,  Simon Williams

IPC: A61K49/16 ,  C07K16/28 ,  C07K5/02 ,  A61K51/04 ,  A61K51/08 ,  A61K51/10

CPC classification number: A61K49/16 ,  A61K51/0482 ,  A61K51/08 ,  A61K51/088 ,  A61K51/103 ,  A61K51/1051 ,  A61K51/1093 ,  C07B59/002 ,  C07D207/404 ,  C07D207/452 ,  C07K1/13 ,  C07K5/02 ,  C07K16/28

Abstract: Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests. The [125I] HIP-DOTA label reagent 6 is prepared by an efficient and convenient process.