公开(公告)号：US20240166741A1

公开(公告)日：2024-05-23

申请号：US18334531

申请日：2023-06-14

Applicant: Genentech, Inc.

Inventor： Jane Grogan ,  Robert J. Johnston ,  Bryan Irving ,  Jason Hackney ,  Xin Yu ,  Dan Eaton ,  Kristin Bowles ,  Laetitia Comps-Agrar

IPC: C07K16/28 ,  A01K67/0276 ,  A61K39/395 ,  A61K45/06 ,  C07K14/705 ,  C07K16/30

CPC classification number: C07K16/2803 ,  A01K67/0276 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  C07K14/70596 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K16/3046 ,  C07K16/3053 ,  C07K16/3061 ,  C07K16/3069 ,  A61K2039/507

Abstract: The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection.

公开(公告)号：US09499596B2

公开(公告)日：2016-11-22

申请号：US13648191

申请日：2012-10-09

Applicant: Genentech, Inc.

Inventor： Hilary Clark ,  Dan Eaton ,  Lino Gonzalez ,  Jane Grogan ,  Jason Hackney ,  Kristin Bowles ,  Xin Yu

IPC: A61K39/35 ,  C12N5/00 ,  C12N5/02 ,  C07K16/00 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  G01N33/50 ,  G01N33/564 ,  G01N33/569 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K2039/505 ,  C07K14/4702 ,  C07K14/70503 ,  C07K16/18 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76 ,  G01N33/505 ,  G01N33/564 ,  G01N33/56972 ,  Y02A50/466

Abstract: The present invention relates to compositions and methods of using those compositions for the diagnosis and treatment of immune related diseases.

Abstract translation: 本发明涉及使用这些组合物来诊断和治疗免疫相关疾病的组合物和方法。

公开(公告)号：US20210340253A1

公开(公告)日：2021-11-04

申请号：US17367094

申请日：2021-07-02

Applicant: Genentech, Inc.

Inventor： Jane Grogan ,  Robert J. Johnston ,  Bryan Irving ,  Jason Hackney ,  Xin Yu ,  Dan Eaton ,  Kristin Bowles ,  Laetitia Comps-Agrar

IPC: C07K16/28 ,  A01K67/027 ,  C07K14/705 ,  A61K39/395 ,  A61K45/06 ,  C07K16/30

Abstract: The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection.

公开(公告)号：US20210332132A1

公开(公告)日：2021-10-28

申请号：US17367133

申请日：2021-07-02

Applicant: Genentech, Inc.

Inventor： Jane Grogan ,  Robert J. Johnston ,  Bryan Irving ,  Jason Hackney ,  Xin Yu ,  Dan Eaton ,  Kristin Bowles ,  Laetitia Comps-Agrar

IPC: C07K16/28 ,  A01K67/027 ,  C07K14/705 ,  A61K39/395 ,  A61K45/06 ,  C07K16/30

Abstract: The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection.

公开(公告)号：US10377823B2

公开(公告)日：2019-08-13

申请号：US15231032

申请日：2016-08-08

Applicant: Genentech, Inc.

Inventor： Hilary Clark ,  Dan Eaton ,  Lino Gonzalez, Jr. ,  Jane Grogan ,  Jason A. Hackney ,  Kristin Bowles ,  Xin Yu

IPC: C07K16/00 ,  C12P21/08 ,  C07K16/28 ,  C07K14/705 ,  C07K16/18 ,  G01N33/50 ,  G01N33/564 ,  G01N33/569 ,  C07K14/47 ,  A61K39/00

Abstract: The present invention relates to compositions and methods of using those compositions for the diagnosis and treatment of immune related diseases.

公开(公告)号：US09873740B2

公开(公告)日：2018-01-23

申请号：US14333375

申请日：2014-07-16

Applicant: Genentech, Inc.

Inventor： Jane Grogan ,  Robert J. Johnston ,  Bryan Irving ,  Jason Hackney ,  Xin Yu ,  Dan Eaton ,  Kristin Bowles ,  Laetitia Comps-Agrar

IPC: C07K16/28 ,  A61K39/395 ,  A01K67/027 ,  C07K14/705 ,  A61K45/06 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0331 ,  A01K2267/0387 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/507 ,  C07K14/70596 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K16/3046 ,  C07K16/3053 ,  C07K16/3061 ,  C07K16/3069 ,  C07K2319/30 ,  Y02A50/466

Abstract: The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection.