公开(公告)号：US20150158952A1

公开(公告)日：2015-06-11

申请号：US14552244

申请日：2014-11-24

Applicant: GENENTECH, INC.

Inventor： Weiguang MAO ,  Jagath Reddy JUNUTULA ,  Paul POLAKIS

IPC: C07K16/30 ,  A61K38/05 ,  A61K45/06 ,  A61K47/48

CPC classification number: C07K16/28 ,  A61K38/05 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6869 ,  A61K47/6889 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3069 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/40 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/77 ,  G01N33/574 ,  G01N33/57492

Abstract: Cysteine engineered anti-TENB2 antibodies are engineered by replacing one or more amino acids of a parent anti-TENB2 antibody with non cross-linked, reactive cysteine amino acids. Methods of design, preparation, screening, and selection of the cysteine engineered anti-TENB2 antibodies are provided. Cysteine engineered anti-TENB2 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-TENB2 antibody-drug conjugates having Formula I: Ab-(L-D)p  I where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed.

Abstract translation: 通过用非交联的反应性半胱氨酸氨基酸替代亲本抗TENB2抗体的一个或多个氨基酸来工程化半胱氨酸改造的抗TENB2抗体。 提供了设计，制备，筛选和选择半胱氨酸改造的抗TENB2抗体的方法。 半胱氨酸改造的抗TENB2抗体（Ab）通过接头（L）与一个或多个药物部分（D）缀合以形成具有式I：Ab-（LD）p I的半胱氨酸改造的抗TENB2抗体 - 药物共轭物，其中p 公开了半胱氨酸改造的抗体药物化合物和组合物的诊断和治疗用途。

公开(公告)号：US20240309088A1

公开(公告)日：2024-09-19

申请号：US18392623

申请日：2023-12-21

Applicant: Genentech, Inc.

Inventor： Yvonne CHEN ,  Mark DENNIS ,  David DORNAN ,  Kristi ELKINS ,  Jagath Reddy JUNUTULA ,  Andrew POLSON ,  Bing ZHENG

IPC: C07K16/28 ,  A61K31/537 ,  A61K38/05 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/68 ,  A61K51/10 ,  C07K16/30 ,  G01N33/574

CPC classification number: C07K16/2803 ,  A61K31/537 ,  A61K38/05 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6867 ,  A61K51/1027 ,  C07K16/3061 ,  G01N33/57492 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/92 ,  Y02A50/30

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20220023437A1

公开(公告)日：2022-01-27

申请号：US17234695

申请日：2021-04-19

Applicant: Genentech, Inc.

Inventor： Yvonne CHEN ,  Mark DENNIS ,  Kristi ELKINS ,  Jagath Reddy JUNUTULA ,  Andrew POLSON ,  Bing ZHENG

IPC: A61K47/68 ,  A61K47/54 ,  A61P35/00

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20150314016A1

公开(公告)日：2015-11-05

申请号：US14734957

申请日：2015-06-09

Applicant: Genentech, Inc.

Inventor： Yvonne CHEN ,  Mark DENNIS ,  David DORNAN ,  Kristi ELKINS ,  Jagath Reddy JUNUTULA ,  Andrew POLSON ,  Bing ZHENG

IPC: A61K47/48 ,  A61K38/05 ,  A61K31/537 ,  A61K51/10

CPC classification number: C07K16/2803 ,  A61K31/537 ,  A61K38/05 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6867 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/92 ,  G01N33/57492 ,  Y02A50/412 ,  Y02A50/423

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

Abstract translation: 本发明涉及可用于治疗哺乳动物造血肿瘤的物质组合物，以及使用这些物质组合物的方法。

公开(公告)号：US20200247887A1

公开(公告)日：2020-08-06

申请号：US16600331

申请日：2019-10-11

Applicant: Genentech, Inc.

Inventor： Yvonne CHEN ,  Mark DENNIS ,  David DORNAN ,  Kristi ELKINS ,  Jagath Reddy JUNUTULA ,  Andrew POLSON ,  Bing ZHENG

IPC: C07K16/28 ,  G01N33/574 ,  C07K16/30 ,  A61K38/05 ,  A61K31/537 ,  A61K45/06 ,  A61K39/395 ,  A61K47/68 ,  A61K51/10

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20200079852A1

公开(公告)日：2020-03-12

申请号：US16691437

申请日：2019-11-21

Applicant: Genentech, Inc.

Inventor： Yvonne CHEN ,  Mark DENNIS ,  David DORNAN ,  Kristi ELKINS ,  Jagath Reddy JUNUTULA ,  Andrew POLSON ,  Bing ZHENG

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395 ,  G01N33/574 ,  A61K47/68 ,  A61K51/10 ,  C07K16/30 ,  A61K31/537 ,  A61K38/05

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20170058032A1

公开(公告)日：2017-03-02

申请号：US15349964

申请日：2016-11-11

Applicant: Genentech, Inc.

Inventor： Yvonne CHEN ,  Mark DENNIS ,  David DORNAN ,  Kristi ELKINS ,  Jagath Reddy JUNUTULA ,  Andrew POLSON ,  Bing ZHENG

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395 ,  A61K47/48

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

Abstract translation: 本发明涉及可用于治疗哺乳动物造血肿瘤的物质组合物，以及使用这些物质组合物的方法。