公开(公告)号：US20040231011A1

公开(公告)日：2004-11-18

申请号：US10871907

申请日：2004-06-17

Applicant: Genentech, Inc.

Inventor： Avi J. Ashkenazi ,  David Botstein ,  Kelly H. Dodge ,  Audrey Goddard ,  Austin L. Gurney ,  Kyung Jin Kim ,  David A. Lawrence ,  Robert Pitti ,  Margaret A. Roy ,  Daniel B. Tumas ,  William I. Wood

IPC: A01K067/027 ,  C07H021/04 ,  C07K014/705 ,  C12N005/06

CPC classification number: C07K14/70578 ,  A01K2217/05 ,  C07H21/04

Abstract: A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.

公开(公告)号：US20020065210A1

公开(公告)日：2002-05-30

申请号：US09894924

申请日：2001-06-28

Applicant: Genentech, Inc.

Inventor： Avi J. Ashkenazi ,  David Botstein ,  Kelly H. Dodge ,  Audrey Goddard ,  Austin L. Gurney ,  Kyung Jin Kim ,  David A. Lawrence ,  Robert Pitti ,  Margaret A. Roy ,  Daniel B. Tumas ,  William I. Wood

IPC: A61K031/00 ,  A01K067/027 ,  C07H021/04 ,  A61K039/395 ,  C12P021/02

CPC classification number: A01K67/0275 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/70575 ,  C07K14/70578 ,  C07K16/2875 ,  C07K16/2878 ,  C07K2317/73 ,  C07K2319/00 ,  C12N2799/026

Abstract: A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.

Abstract translation: 提供了标识为DcR3的TNFR同源物。 还提供了编码DcR3的核酸分子，嵌合分子和DcR3的抗体。

公开(公告)号：US20040014176A1

公开(公告)日：2004-01-22

申请号：US10456819

申请日：2003-06-06

Applicant: Genentech, Inc.

Inventor： Avi J. Ashkenzai ,  David Botstein ,  Kelly H. Dodge ,  Audrey Goddard ,  Austin L. Gurney ,  Kyung Jin Kim ,  David A. Lawrence ,  Robert Pitti ,  Margaret A. Roy ,  Daniel B. Tumas ,  William I. Wood

IPC: C12P021/02 ,  C12N005/06 ,  C07K014/715 ,  C07K016/24 ,  C07H021/04

CPC classification number: A01K67/0275 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/70575 ,  C07K14/70578 ,  C07K16/2875 ,  C07K16/2878 ,  C07K2317/73 ,  C07K2319/00 ,  C12N2799/026

Abstract: A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.

公开(公告)号：US20020061559A1

公开(公告)日：2002-05-23

申请号：US09896096

申请日：2001-06-28

Applicant: Genentech, Inc.

Inventor： Avi J. Ashkenazi ,  David Botstein ,  Kelly H. Dodge ,  Audrey Goddard ,  Austin L. Gurney ,  Kyung Jin Kim ,  David A. Lawrence ,  Robert Pitti ,  Margaret A. Roy ,  Daniel B. Tumas ,  William I. Wood

IPC: C12P021/02 ,  A01K067/027 ,  C07H021/04 ,  C12N005/06 ,  C07K014/705

CPC classification number: A01K67/0275 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/70575 ,  C07K14/70578 ,  C07K16/2875 ,  C07K16/2878 ,  C07K2317/73 ,  C07K2319/00 ,  C12N2799/026

Abstract: A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.

公开(公告)号：US20040175791A1

公开(公告)日：2004-09-09

申请号：US10688132

申请日：2003-10-17

Applicant: Genentech, Inc.

Inventor： Avi J. Ashkenazi ,  David Botstein ,  Kelly H. Dodge ,  Audrey Goddard ,  Austin L. Gurney ,  Kyung Jin Kim ,  David A. Lawrence ,  Robert Pitti ,  Margaret A. Roy ,  Daniel B. Tumas ,  William I. Wood

IPC: C07K014/705 ,  C07K016/28 ,  C07H021/04

CPC classification number: A01K67/0275 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/70575 ,  C07K14/70578 ,  C07K16/2875 ,  C07K16/2878 ,  C07K2317/73 ,  C07K2319/00 ,  C12N2799/026

Abstract: A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.

Abstract translation: 提供了标识为DcR3的TNFR同源物。 还提供了编码DcR3的核酸分子，嵌合分子和DcR3的抗体。

公开(公告)号：US20020146707A1

公开(公告)日：2002-10-10

申请号：US09901257

申请日：2001-07-09

Applicant: Genentech, Inc.

Inventor： David Botstein ,  Audrey Goddard ,  David A. Lawrence ,  Diane Pennica ,  Margaret Ann Roy ,  William I. Wood

IPC: C12Q001/68 ,  G01N033/574 ,  C07H021/04

CPC classification number: C07K14/52 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K16/18 ,  C07K16/24 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02 ,  G01N2500/00

Abstract: The invention concerns composititions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Acordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.

公开(公告)号：US20020102622A1

公开(公告)日：2002-08-01

申请号：US09901540

申请日：2001-07-09

Applicant: Genentech, Inc.

Inventor： David Botstein ,  Audrey Goddard ,  David A. Lawrence ,  Diane Pennica ,  Margaret Ann Roy ,  William I. Wood

IPC: G01N033/574 ,  C07H021/04 ,  C12N009/64 ,  C12N001/18 ,  C12P021/02 ,  C12N005/06

CPC classification number: C07K14/52 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K16/18 ,  C07K16/24 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02 ,  G01N2500/00

Abstract: The invention concerns composititions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Acordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.

Abstract translation: 本发明涉及用于诊断和治疗哺乳动物（包括人）中的肿瘤细胞生长和增殖的复合和方法。 本发明基于在肿瘤细胞基因组中扩增的心肌营养因子-1基因的鉴定。 预期这种基因扩增与基因产物的过表达有关，并有助于肿瘤发生。 因此，由扩增的基因编码的心肌营养因子-1多肽被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。