公开(公告)号：US20160145349A1

公开(公告)日：2016-05-26

申请号：US14948911

申请日：2015-11-23

Applicant: Genentech, Inc.

Inventor： Arthur Huang ,  Robert Kelley ,  Henry Lowman ,  Menno Van Lookeren Campagne ,  Charles Winter

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention relates to anti-Factor D antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

Abstract translation: 本发明涉及抗因子D抗体，其核酸和氨基酸序列，携带这些抗体的细胞和载体及其生产及其在制备用于治疗与过量或不受控制的疾病和病症的组合物和药物的用途 补体激活。 这些抗体可用于疾病的诊断，预防和治疗。

公开(公告)号：US20190185579A1

公开(公告)日：2019-06-20

申请号：US16048002

申请日：2018-07-27

Applicant: Genentech, Inc.

Inventor： Arthur Huang ,  Robert Kelley ,  Henry Lowman ,  Menno Van Lookeren Campagne ,  Charles Winter

IPC: C07K16/40 ,  C07K16/18

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention relates to anti-Factor D antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

公开(公告)号：US09676868B2

公开(公告)日：2017-06-13

申请号：US14033175

申请日：2013-09-20

Applicant: GENENTECH, INC.

Inventor： Arthur Huang ,  Robert Kelley ,  Henry Lowman ,  Menno Van Lookeren Campagne ,  Charles Winter

IPC: C07K16/40 ,  A61K39/395 ,  C07K16/18 ,  A61K39/00

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention relates to anti-Factor D antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

公开(公告)号：US20140065137A1

公开(公告)日：2014-03-06

申请号：US14033175

申请日：2013-09-20

Applicant: GENENTECH, INC.

Inventor： Arthur Huang ,  Robert Kelley ,  Henry Lowman ,  Menno Van Lookeren Campagne ,  Charles Winter

IPC: C07K16/18

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention relates to anti-Factor D antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

Abstract translation: 本发明涉及抗因子D抗体，其核酸和氨基酸序列，携带这些抗体的细胞和载体及其生产及其在制备用于治疗与过量或不受控制的疾病和病症的组合物和药物的用途 补体激活。 这些抗体可用于疾病的诊断，预防和治疗。