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1.发明公开公开(公告)号：US20240150823A1
公开(公告)日：2024-05-09
申请号：US18544053
申请日：2023-12-18
发明人： David BUSE , David Howard COMBS , Norbert D. HAGEN , David OPALSKY , Bruce RICHARDSON , Anita PRASAD , Keith MORAVICK , Tyler MOORE , Byron J. Knight
CPC分类号： C12Q1/686 , B01L7/52 , G01N21/6452 , B01L9/06 , B01L2200/142 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , B01L2300/1822 , G01N2021/6484
摘要： An apparatus for incubating a plurality of receptacles includes one or more thermally-conductive receptacle holders, each comprising a plurality of receptacle wells. A thermally-conductive support is associated with each of the receptacle holders, and a thermal element is positioned between the associated support and the receptacle holder. A heat sink is in thermal communication with the support and comprises a plurality of spaced-apart fins. An optical fiber associated with each receptacle well has a first end positioned adjacent to or within a through-hole formed in the receptacle well and extends through through-holes formed in the support and the heat sink aligned with the through-hole of the receptacle well. Each of the optical fibers is positioned between two adjacent fins of the plurality of fins.
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公开(公告)号：US20210062245A1
公开(公告)日：2021-03-04
申请号：US17027363
申请日：2020-09-21
发明人： David BUSE , David Howard COMBS , Norbert D. HAGEN , David OPALSKY , Bruce RICHARDSON , Anita PRASAD , Keith MORAVICK , Tyler MOORE , Byron J. Knight
摘要： An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder that includes multiple receptacle wells. Each well can receive a receptacle and has a through-hole extending from an inner surface of the well to an outer surface of the holder. The apparatus includes multiple optical fibers, and each optical fiber has a first end in optical communication with an associated well and a second end in optical communication with an excitation signal source and/or an emission signal detector. The first end of each optical fiber is moveable with respect to the through-hole. A cover is movable between an open position and a closed position relative to the receptacle holder, and the first end of each optical fiber moves with respect to the through-hole of the associated well as the cover moves to the open or closed position or when the cover moves into or out of contact with any receptacles within the wells.
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公开(公告)号：US20210032681A1
公开(公告)日：2021-02-04
申请号：US17028367
申请日：2020-09-22
发明人： David BUSE , David Howard COMBS , Nobert D. HAGEN , David OPALSKY , Bruce RICHARDSON , Anita PRASAD , Keith MORAVICK , Tyler MOORE , Byron J. KNIGHT
摘要： Multiple receptacles containing a reaction mixture are transported to corresponding receptacle wells of a thermally-conductive receptacle holder in thermal communication with a support that is in thermal communication with a heat sink. The heat sink is pre-heated to a temperature above ambient temperature, and the temperature of the receptacle holder is cycled. Optical communication is established between each of the receptacle wells and an excitation signal source and an emission signal detector during cycling, and whether an emission signal is emitted from any of the receptacles is determined as an indication of the presence of a target nucleic acid.
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公开(公告)号：US20210002705A1
公开(公告)日：2021-01-07
申请号：US17027433
申请日：2020-09-21
发明人： David BUSE , David Howard COMBS , Norbert D. HAGEN , David OPALSKY , Bruce RICHARDSON , Anita PRASAD , Keith MORAVICK , Tyler MOORE , Byron J. Knight
摘要： An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder with multiple receptacle wells. Each well has a through-hole extending from an inner surface of the well to an outer surface of the holder. A cover is rotatable between an open position and a closed position relative to the holder and is configured to exert a force onto any receptacles in the wells when the cover is in the closed position. The apparatus includes multiple optical fibers, and each of the optical fibers provides optical communication between one of the wells and an excitation signal source and/or an emission signal detector. A thermal element is positioned between a thermally-conductive support and the receptacle holder.
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公开(公告)号：US20140038192A1
公开(公告)日：2014-02-06
申请号：US13956022
申请日：2013-07-31
发明人： David BUSE , David Howard COMBS , Norbert D. HAGEN , David OPALSKY , Bruce RICHARDSON , Anita PRASAD , Keith MORAVICK , Tyler MOORE
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , B01L7/52 , B01L9/06 , B01L2200/141 , B01L2200/142 , B01L2300/042 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , B01L2300/1822 , G01N21/6452 , G01N2021/6482 , G01N2021/6484
摘要： System, apparatus, and method for cycling the temperature of at least one receptacle holder that is adapted for use in an automated instrument capable of performing nucleic acid-based amplification tests. Also provided are methods for conducting automated, random-access incubation processes using the same.
摘要翻译： 用于循环适于在能够进行基于核酸的扩增测试的自动化仪器中使用的至少一个容器保持器的温度的系统，装置和方法。 还提供了使用其进行自动化，随机存取培养过程的方法。
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6.发明公开公开(公告)号：US20240159972A1
公开(公告)日：2024-05-16
申请号：US18391471
申请日：2023-12-20
发明人： David BUSE , David Howard COMBS , Norbert D. HAGEN , David OPALSKY , Bruce RICHARDSON , Anita PRASAD , Keith MORAVICK , Tyler MOORE
CPC分类号： G02B6/3668 , G01N21/253 , G01N21/6452 , G02B6/06 , G02B6/08 , G02B6/3672 , G02B6/4214 , G02B6/4246 , G02B6/4269 , G01N2021/6484
摘要： An apparatus for incubating the contents of a plurality of receptacles and for detecting a signal emitted by the contents of each of the receptacle includes a plurality of receptacle holders configured to incubate the contents of each a plurality of receptacles held by each of the receptacle holders. A controller is coupled to each of the receptacle holders and is configured to independently control an incubation temperature of each of the receptacle holders to independently control a temperature at which the receptacles held by each of the receptacle holders is incubated. At least one signal detector is configured to detect a signal emitted by the contents of each of the receptacles held in each of the receptacle holders, and a signal detector indexer is configured to successively optically couple each signal detector with each of the receptacles held in each of the receptacle holders to detect optical emissions from each successively coupled receptacle.
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7.发明公开公开(公告)号：US20240035079A1
公开(公告)日：2024-02-01
申请号：US18379892
申请日：2023-10-13
发明人： David BUSE , David Howard COMBS , Norbert D. HAGEN , David OPALSKY , Bruce RICHARDSON , Anita PRASAD , Keith MORAVICK , Tyler MOORE , Byron J. KNIGHT
CPC分类号： C12Q1/686 , B01L7/52 , G01N21/6452 , B01L2200/141 , B01L2200/142 , B01L2300/042 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , B01L2300/1822 , B01L9/06
摘要： An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder that includes multiple receptacle wells. Each well can receive a receptacle and has a through-hole extending from an inner surface of the well to an outer surface of the holder. The apparatus includes multiple optical fibers, and each optical fiber has a first end in optical communication with an associated well and a second end in optical communication with an excitation signal source and/or an emission signal detector. The first end of each optical fiber is moveable with respect to the through-hole. A cover is movable between an open position and a closed position relative to the receptacle holder, and the first end of each optical fiber moves with respect to the through-hole of the associated well as the cover moves to the open or closed position or when the cover moves into or out of contact with any receptacles within the wells.
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公开(公告)号：US20210017576A1
公开(公告)日：2021-01-21
申请号：US17029930
申请日：2020-09-23
发明人： David BUSE , David Howard COMBS , Norbert D. HAGEN , David OPALSKY , Bruce RICHARDSON , Anita PRASAD , Keith MORAVICK , Tyler MOORE
摘要： An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder with front and back surfaces. The front surface includes a row of receptacle wells, and an outer surface of each well has a frustoconical shape, an inner surface of each well receives a receptacle, and each well has a through-hole extending between the inner and outer surfaces thereof. One or more thermal elements in contact with the back surface of the holder alter a temperature(s) of the holder. The apparatus includes multiple optical fibers, and each optical fiber provides optical communication between one of the wells and an excitation signal source and/or an emission signal detector. A first end of each optical fiber is disposed outside, within, or extends through the through-hole of a corresponding well, and a second end of each optical fiber is in optical communication with the excitation signal source and/or the emission signal detector.
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公开(公告)号：US20190127779A1
公开(公告)日：2019-05-02
申请号：US16224054
申请日：2018-12-18
发明人： David Howard COMBS
摘要： A receptacle transport mechanism comprises a body, a plunger configured to be movable with respect to the body, and one or more limbs movably attached to the body and positioned in operative engagement with the plunger. The plunger is movable with respect to the body between a first position whereby engagement by the plunger with the one or more limbs positions a lower portion of each limb proximal to the body and a second position whereby engagement by the plunger with the one or more limbs extends the lower portion of each limb outwardly relative to the body.
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