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    [4,5]-fused-3,6-disubstituted-pyridazines with sulfur-containing substituents in position three for the treatment of neoplasia
    10.
    发明授权
    [4,5]-fused-3,6-disubstituted-pyridazines with sulfur-containing substituents in position three for the treatment of neoplasia 失效
    [4,5] - 三位含硫取代基的3,6-二取代哒嗪用于治疗瘤形成

    公开(公告)号：US06486158B1

    公开(公告)日：2002-11-26

    申请号：US09875107

    申请日：2001-06-06

    申请人： Xiaojing Wang ,  Gerhard Sperl ,  Paul Gross ,  Rifat Pamukcu ,  Gary A. Piazza

    发明人： Xiaojing Wang ,  Gerhard Sperl ,  Paul Gross ,  Rifat Pamukcu ,  Gary A. Piazza

    IPC分类号： C07D47104

    CPC分类号： C07D237/30 ,  C07D237/32

    摘要： [4,5]-Fused-3,6 disubstituted-pydidazines of Formula I are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasia: wherein Y1 and Y2 are independently selected from the group consisting of (CH2)n,—C(X)—NH—,—(CH2)n—C(X)—O—, and X is O or S; R1 is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, and substituted or unsubstituted phenyl, pyridinyl, and the like; R2 is selected from the group consisting of substituted or unsubstituted phenyl, benzyl, pyridinyl, and the like; “A” is a benzene ring fused with the pyridazine ring; and R3 is independently selected in each instance form the group consisting of halogen, lower alkyl, and the like.

    摘要翻译： [4,5] - 式I的3,6-二取代哒嗪可用于诱导或促进凋亡和阻止不受控制的肿瘤细胞增殖，并且特别可用于阻滞和治疗瘤形成：其中Y 1和Y 2被独立地选择 由（CH 2）n，-C（X）-NH - ， - （CH 2）n C（X）-O-，X为O或S组成的组; R 1选自低级烷基，低级 烯基，低级炔基和取代或未取代的苯基，吡啶基等; R2选自取代或未取代的苯基，苄基，吡啶基等;“A”是与哒嗪环稠合的苯环 ; R 3各自独立地选自卤素，低级烷基等。