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![5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS](/abs-image/US/2018/01/04/US20180002293A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180002293A1
公开(公告)日：2018-01-04
申请号：US15538393
申请日：2015-12-18
发明人： Franck Laurent BREBION , Luke Jonathan ALVEY , David AMANTINI , Frédéric André DE CEUNINCK , Pierre Marc Marie Joseph DEPREZ , Romain Luc Marie GOSMINI , Hélène Marie JARY , Christophe PEIXOTO , Iuliana Ecaterina POP-BOTEZ , Marie Laurence Claire VARIN
IPC分类号： C07D233/78 , C07D405/12 , C07D403/14 , C07D401/14 , A61K31/496 , C07D401/12 , C07D401/04 , A61K31/5377 , C07D417/12 , C07D403/06
CPC分类号： C07D233/78 , A61K31/496 , A61K31/5377 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D417/12
摘要： The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, and Cy are as defined herein.The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.
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![5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS](/abs-image/US/2021/10/07/US20210309614A1/abs.jpg.150x150.jpg)
公开(公告)号：US20210309614A1
公开(公告)日：2021-10-07
申请号：US17141902
申请日：2021-01-05
发明人： Franck Laurent BREBION , Luke Jonathan ALVEY , David AMANTINI , Frédéric André DE CEUNINCK , Pierre Marc Marie Joseph DEPREZ , Romain Luc Marie GOSMINI , Hélène Marie JARY , Christophe PEIXOTO , Iuliana Ecaterina POP-BOTEZ , Marie Laurence Claire VARIN
IPC分类号： C07D233/78 , C07D403/06 , A61P19/02 , A61P19/04 , A61K31/496 , A61K31/5377 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D417/12 , A61K31/55
摘要： The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, and Cy are as defined herein.
The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.-
![5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS](/abs-image/US/2020/07/09/US20200216397A1/abs.jpg.150x150.jpg)
3.发明申请公开(公告)号：US20200216397A1
公开(公告)日：2020-07-09
申请号：US16653668
申请日：2019-10-15
发明人： Franck Laurent BREBION , Luke Jonathan ALVEY , David AMANTINI , Frédéric André DE CEUNINCK , Pierre Marc Marie Joseph DEPREZ , Romain Luc Marie GOSMINI , Hélène Marie JARY , Christophe PEIXOTO , Iuliana Ecaterina POP-BOTEZ , Marie Laurence Claire VARIN
IPC分类号： C07D233/78 , A61P19/04 , A61P19/02 , A61K31/55 , C07D417/12 , C07D405/12 , C07D403/14 , C07D401/14 , C07D401/12 , C07D401/04 , A61K31/5377 , A61K31/496 , C07D403/06
摘要： The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, and Cy are as defined herein.The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.
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![5-[3-[PIPERAZIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS](/abs-image/US/2019/10/03/US20190300503A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190300503A1
公开(公告)日：2019-10-03
申请号：US16308380
申请日：2017-06-01
发明人： Frédéric Gilbert LABÉGUÈRE , Rama HENG , Frédéric André DE CEUNINCK , Luke Jonathan ALVEY , David AMANTINI , Franck Laurent BREBION , Pierre Marc Marie Joseph DEPREZ , Romain Luc Marie GOSMINI , Hélène Marie JARY , Christophe PEIXOTO , Iuliana Ecaterina POP-BOTEZ , Marie Laurence Claire VARIN
IPC分类号： C07D401/12 , C07D401/14 , C07D409/14 , A61P19/02
摘要： The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, R6, Cy, and the subscript n are as defined herein.The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering the compound of the invention.
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![5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS](/abs-image/US/2018/09/13/US20180258052A1/abs.jpg.150x150.jpg)
5.发明申请公开(公告)号：US20180258052A1
公开(公告)日：2018-09-13
申请号：US15896779
申请日：2018-02-14
发明人： Franck Laurent BREBION , Luke Jonathan ALVEY , David AMANTINI , Frédéric André DE CEUNINCK , Pierre Marc Marie Joseph DEPREZ , Romain Luc Marie GOSMINI , Hélène Marie JARY , Christophe PEIXOTO , Iuliana Ecaterina POP-BOTEZ , Marie Laurence Claire VARIN
IPC分类号： C07D233/78 , C07D403/14 , A61K31/5377 , A61K31/496 , C07D401/12 , C07D405/12 , C07D417/12 , C07D401/04 , C07D401/14 , C07D403/06
摘要： The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, and Cy are as defined herein.The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.
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![5-[3-[PIPERAZIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS](/abs-image/US/2019/10/17/US20190315719A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190315719A1
公开(公告)日：2019-10-17
申请号：US16308349
申请日：2017-06-01
申请人： Galapagos NV
发明人： Frédéric Gilbert LABÉGUÈRE , Rama HENG , Frédéric André DE CEUNINCK , Luke Jonathan ALVEY , David AMANTINI , Franck Laurent BREBION , Pierre Marc Marie Joseph DEPREZ , Romain Luc Marie GOSMINI , Hélène Marie JARY , Christophe PEIXOTO , Iuliana Ecaterina POP-BOTEZ , Marie Laurence Claire VARIN
IPC分类号： C07D403/06 , C07D403/14 , C07D401/14
摘要： The present invention discloses compounds according to Formula I: Wherein R1, R2, R3a, R3b, R6a, R6b, the subscript n and Cy are as defined herein.The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering the compound of the invention.
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