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    NOVEL DIHYDROPYRIMIDINOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS (GPR84 ANTAGONISTS)
    9.
    发明申请
    NOVEL DIHYDROPYRIMIDINOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS (GPR84 ANTAGONISTS) 有权
    新型二氢咪唑啉酮和其药物组合物治疗炎症性疾病（GPR84拮抗剂）

    公开(公告)号：US20160039807A1

    公开(公告)日：2016-02-11

    申请号：US14653323

    申请日：2013-12-17

    申请人： GALAPAGOS NV

    发明人： Frédéric Gilbert LABÉGUÈRE ,  Gregory John Robert NEWSOME ,  Luke Jonathan ALVEY ,  Laurent Raymond Maurice SANIÈRE ,  Stephen Robert FLETCHER

    IPC分类号： C07D471/04 ,  A61K31/5377 ,  C07D519/00 ,  A61K31/519

    CPC分类号： C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  C07D519/00

    摘要： A compound according to Formula (Ia), wherein Cy, L1, G, and R1 are as described herein. The present invention relates to novel compounds according to Formula (I) that antagonize GPR84, a G-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions (for example inflammatory bowel diseases (IBD), rheumatoid arthritis, vasculitis), lung diseases (e.g. chronic obstructive pulmonary disease (COPD) and lung interstitial diseases (e.g. idiopathic pulmonary fibrosis (IPF))), neuroinflammatory conditions, infectious diseases, autoimmune diseases, endocrine and/or metabolic diseases, and/or diseases involving impairment of immune cell functions by administering a compound of the invention.

    摘要翻译： 根据式（Ia）的化合物，其中Cy，L1，G和R1如本文所述。 本发明涉及拮抗参与炎性病症的G蛋白偶联受体GPR84的式（I）的新化合物，以及这些新化合物的制备方法，包含这些化合物的药物组合物，以及用于 预防和/或治疗炎性病症（例如炎性肠病（IBD），类风湿性关节炎，血管炎），肺部疾病（例如慢性阻塞性肺疾病（COPD）和肺间质疾病（例如特发性肺纤维化（IPF））） ，神经炎症性疾病，感染性疾病，自身免疫疾病，内分泌和/或代谢疾病，和/或涉及免疫细胞功能损害的疾病，通过施用本发明的化合物。

    NOVEL DIHYDROPYRIMIDINOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS.
    10.
    发明申请
    NOVEL DIHYDROPYRIMIDINOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS. 有权
    新型二氢咪唑啉酮和其药物组合物用于治疗炎症性疾病。

    公开(公告)号：US20130165437A1

    公开(公告)日：2013-06-27

    申请号：US13721788

    申请日：2012-12-20

    申请人： GALAPAGOS NV

    发明人： Frédéric Gilbert LABÉGUÈRE ,  Gregory John Robert NEWSOME ,  Luke Jonathan ALVEY ,  Laurent Raymond Maurice SANIÈRE ,  Stephen Robert FLETCHER

    IPC分类号： C07D471/04 ,  A61K31/5377 ,  A61K45/06 ,  A61K31/519

    CPC分类号： C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K45/06

    摘要： A compound according to Formula Ia: wherein L1, G, and R1 are as described herein.The present invention relates to novel compounds according to Formula I that antagonize GPR84, a G-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions (for example inflammatory bowel diseases (IBD), rheumatoid arthritis, vasculitis, lung diseases (e.g. chronic obstructive pulmonary disease (COPD) and lung interstitial diseases (e.g. idiopathic pulmonary fibrosis (IPF))), neuroinflammatory conditions, infectious diseases, autoimmune diseases, endocrine and/or metabolic diseases, and/or diseases involving impairment of immune cell functions by administering a compound of the invention.

    摘要翻译： 根据式Ia的化合物：其中L 1，G和R 1如本文所述。 本发明涉及拮抗GPR84的式I的新型化合物，涉及炎性病症的G蛋白偶联受体，以及这些新化合物的制备方法，包含这些化合物的药物组合物，以及预防方法 炎症性疾病（IBD），类风湿性关节炎，血管炎，肺部疾病（如慢性阻塞性肺疾病（COPD）和肺间质性疾病（如特发性肺纤维化（IPF）））和/或治疗炎症性疾病 ，传染病，自身免疫性疾病，内分泌和/或代谢疾病，和/或涉及免疫细胞功能损害的疾病，通过施用本发明的化合物。