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    Synthetic composition for microbiota modulation
    2.
    发明授权
    Synthetic composition for microbiota modulation 有权

    公开(公告)号：US11696921B2

    公开(公告)日：2023-07-11

    申请号：US17001118

    申请日：2020-08-24

    申请人： GLYCOM A/S

    发明人： Louise Kristine Vigsnæs ,  Bruce McConnell

    IPC分类号： A61K31/702 ,  A61P3/04 ,  A61P3/10 ,  A61P1/00 ,  A61K9/00

    CPC分类号： A61K31/702 ,  A61K9/0053 ,  A61P1/00 ,  A61P3/04 ,  A61P3/10

    摘要： A human milk oligosaccharide (HMO) or a synthetic composition comprising said HMO, for use in increasing the abundance, particularly the relative abundance, of a Bifidobacterium of the B. adolescentis phylogenic group in the microbiota in the gastro-intestinal tract of a human, preferably a non-infant human. The HMO(s) and/or synthetic composition is useful in; increasing particularly the relative abundance of B. adolescentis and/or B. pseudocatenulatum; for treating or preventing in said non-infant human with type 2 diabetes and/or obesity; an enteropathogenic infection; impaired gut barrier function and/or; an inflammation related to gastro¬intestinal condition, preferably irritable bowel disease (IBD) or irritable bowel syndrome (IBS); as a nutritional composition. The HMO is a fucosylated neutral HMO, a non-fucosylated neutral HMO, or a mixture of a fucosylated and a non-fucosylated neutral HMO. The HMOs comprises 2′-fucosyllactose (preferred), 2′-fucosyllactose (preferred), 3-fucosyllactose, difucosyllactose (preferred), lacto-N-fucopentaose, fucosyl-lacto-N-hexaose, fucosyl-para-lacto-N-hexaose, lacto-N-tetraose (preferred), lacto-N-neotetraose (preferred), lacto-N-hexaose, lacto-N-neohexaose, para-lacto-N-hexaose and para-lacto-N-neohexaose.

    MIXTURE OF HMOS FOR TREATING AUTOIMMUNE DISEASES
    5.
    发明申请
    MIXTURE OF HMOS FOR TREATING AUTOIMMUNE DISEASES 有权

    公开(公告)号：US20210213038A1

    公开(公告)日：2021-07-15

    申请号：US17059942

    申请日：2019-05-31

    申请人： Glycom A/S

    发明人： Louise Kristine Vigsnæs ,  Bruce McConnell ,  Kristine Rothaus Christensen

    IPC分类号： A61K31/702

    摘要： The invention relates to a method, compounds and compositions for the secondary prevention, treatment or dietary management of symptomatic and asymptomatic non-intestinal autoimmune diseases in a non-infant human including Sjogren's syndrome and type 1 diabetes. Said method, compounds and compositions for the secondary prevention, treatment or dietary management include human milk oligosaccharide (HMO), preferably mixtures of human milk oligosaccharides selected from the group of 2′-FL, LNnT, LNT, DFL, and 6′-SL.