专利检索 ap:("GILEAD SCIENCES, INC.") AND inv:"Philip Anthony Morganelli" 第 1 页

1.

发明授权
Polycyclic-carbamoylpyridone compounds and their pharmaceutical use 有权
标题翻译：多环氨基甲酰吡啶酮化合物及其药物用途

公开(公告)号：US09522912B2

公开(公告)日：2016-12-20

申请号：US14977347

申请日：2015-12-21

申请人： Gilead Sciences, Inc.

发明人： Elizabeth M. Bacon , Zhenhong R. Cai , Jeromy J. Cottell , Mingzhe Ji , Haolun Jin , Scott E. Lazerwith , Philip Anthony Morganelli , Hyung-jung Pyun

IPC分类号： A61K31/4985 , C07D471/04 , C07D491/147 , C07D491/20 , A61K45/06

CPC分类号： A61K31/4985 , A61K45/06 , C07D471/04 , C07D491/147 , C07D491/20

摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A′, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

2.

发明申请
SUBSTITUTED 1,2,3,4,6,8,12,12a-OCTAHYDRO-1,4-METHANODIPYRIDO[1,2-a:1',2'-d]PYRAZINES AND METHODS FOR TREATING VIRAL INFECTIONS 有权
标题翻译：取代的1,2,3,4,6,8,12,12a-咔唑-1,4-甲基吡啶并[1,2-a：1'，2'-d]吡啶和治疗病毒感染的方法

公开(公告)号：US20160176885A1

公开(公告)日：2016-06-23

申请号：US14815504

申请日：2015-07-31

申请人： Gilead Sciences, Inc.

发明人： Haolun Jin , Scott E. Lazerwith , Hyung-Jung Pyun , Manoj C. Desai , Teresa Alejandra Trejo Martin , Elizabeth Bacon , Jeromy J. Cottell , Zhenhong R. Cai , Philip Anthony Morganelli , Mingzhe Ji , James G. Taylor , Xiaowu Chen , Michael R. Mish

IPC分类号： C07D487/14

CPC分类号： C07D498/14 , A61K31/498 , A61K31/4985 , A61K31/529 , A61K31/537 , A61K31/551 , A61K31/553 , A61K45/06 , C07D471/18 , C07D471/22 , C07D487/14 , C07D498/18 , A61K2300/00

摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

摘要翻译： 公开了用于治疗人类免疫缺陷病毒（HIV）感染的化合物。所述化合物具有下式（I）：其包括立体异构体及其药学上可接受的盐，其中R1，X，W，Y1，Y2，Z1和Z4如本文所定义。还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

3.

发明申请
POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE 有权

公开(公告)号：US20210015816A1

公开(公告)日：2021-01-21

申请号：US16832230

申请日：2020-03-27

申请人： Gilead Sciences, Inc.

发明人： Elizabeth M. Bacon , Zhenhong R. Cai , Jeromy J. Cottell , Mingzhe Ji , Haolun Jin , Scott E. Lazerwith , Philip Anthony Morganelli , Hyung-Jung Pyun

IPC分类号： A61K31/4985 , C07D471/04 , C07D491/147 , C07D491/20 , A61K45/06

摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A′, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

4.

发明授权
Substituted 3,4,5,6,8,10,14,14a-octahydro-2h-2,6-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazocines and methods for treating viral infections 有权

公开(公告)号：US10689399B2

公开(公告)日：2020-06-23

申请号：US16017371

申请日：2018-06-25

申请人： Gilead Sciences, Inc.

发明人： Elizabeth M. Bacon , Zhenhong R. Cai , Xiaowu Chen , Jeromy J. Cottell , Manoj C. Desai , Mingzhe Ji , Haolun Jin , Scott E. Lazerwith , Michael R. Mish , Philip Anthony Morganelli , Hyung-Jung Pyun , James G. Taylor , Teresa Alejandra Trejo Martin

IPC分类号： A61K31/4985 , C07D413/14 , C07D498/14 , A61K31/537 , C07D471/22 , A61K31/529 , A61K31/551 , A61K31/498 , C07D471/18 , A61K45/06 , C07D498/18 , C07D487/14 , A61K31/553

摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

5.

发明申请
SUBSTITUTED PYRROLIZINE COMPOUNDS AND USES THEREOF 审中-公开

公开(公告)号：US20200061024A1

公开(公告)日：2020-02-27

申请号：US16403247

申请日：2019-05-03

申请人： GILEAD SCIENCES, INC.

发明人： Jinfa Du , Joshua A. Kaplan , Thorsten A. Kirschberg , Tetsuya Kobayashi , Scott E. Lazerwith , Rick Andrew Lee , Jonathan William Medley , Michael L. Mitchell , Philip Anthony Morganelli , Hyung-Jung Pyun , Sophia L. Shevick , Neil H. Squires , William J. Watkins

IPC分类号： A61K31/403 , A61K31/4192 , A61K31/38 , A61K31/16 , A61K31/03 , A61P31/20 , C07D519/00 , C07D487/04

摘要： This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

6.

发明授权
Substituted 2,3,4,5,7,9,13,13a-octahydropyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]OXAZEPINES and methods for treating viral infections 有权

公开(公告)号：US09732092B2

公开(公告)日：2017-08-15

申请号：US15349934

申请日：2016-11-11

申请人： Gilead Sciences, Inc.

发明人： Haolun Jin , Scott E. Lazerwith , Hyung-Jung Pyun , Elizabeth M. Bacon , Philip Anthony Morganelli , Mingzhe Ji

IPC分类号： A61K31/5365 , C07D413/14 , C07D498/14 , A61K45/06 , A61K31/537 , A61K31/553

CPC分类号： C07D498/14 , A61K31/498 , A61K31/4985 , A61K31/529 , A61K31/537 , A61K31/551 , A61K31/553 , A61K45/06 , C07D471/18 , C07D471/22 , C07D487/14 , C07D498/18 , A61K2300/00

摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

7.

发明申请
INHIBITORS OF FLAVIVIRIDAE VIRUSES 审中-公开
标题翻译： FLAVIVIRIDAE病毒的抑制剂

公开(公告)号：US20140030223A1

公开(公告)日：2014-01-30

申请号：US14037296

申请日：2013-09-25

申请人： Gilead Sciences, Inc.

发明人： Eda Canales , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael Martzman , Philip Anthony Morganelli , William J. Watkins , Hong Ye

IPC分类号： A61K31/513 , A61K31/4436 , A61K45/06 , A61K31/4709 , A61K31/501 , C07D417/12 , A61K31/427 , C07D409/12 , A61K31/497

CPC分类号： A61K31/513 , A61K31/427 , A61K31/4436 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K45/06 , C07D333/68 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D493/04

摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

摘要翻译： 提供式I的化合物及其药学上可接受的盐和酯。所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。

8.

发明申请
POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE 有权

公开(公告)号：US20210053988A1

公开(公告)日：2021-02-25

申请号：US16868119

申请日：2020-05-06

申请人： Gilead Sciences, Inc.

发明人： Elizabeth M. Bacon , Zhenhong R. Cai , Xiaowu Chen , Jeromy J. Cottell , Manoj C. Desai , Mingzhe Ji , Haolun Jin , Scott E. Lazerwith , Michael R. Mish , Philip Anthony Morganelli , Hyung-Jung Pyun , James G. Taylor , Teresa Alejandra Trejo Martin

IPC分类号： C07D498/14 , A61K31/537 , C07D471/22 , A61K31/529 , A61K31/551 , A61K31/498 , C07D471/18 , A61K45/06 , C07D498/18 , A61K31/4985 , C07D487/14 , A61K31/553

摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.