![Substituted 3,4,5,6,8,10,14,14a-octahydro-2h-2,6-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazocines and methods for treating viral infections](/docs/US/2020-06-23/US10689399B2/abs.jpg.600x600.jpg)
- 专利标题： Substituted 3,4,5,6,8,10,14,14a-octahydro-2h-2,6-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazocines and methods for treating viral infections
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申请号： US16017371申请日： 2018-06-25
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公开(公告)号： US10689399B2公开(公告)日： 2020-06-23
- 发明人: Elizabeth M. Bacon , Zhenhong R. Cai , Xiaowu Chen , Jeromy J. Cottell , Manoj C. Desai , Mingzhe Ji , Haolun Jin , Scott E. Lazerwith , Michael R. Mish , Philip Anthony Morganelli , Hyung-Jung Pyun , James G. Taylor , Teresa Alejandra Trejo Martin
- 申请人： Gilead Sciences, Inc.
- 申请人地址： US CA Foster City
- 专利权人： Gilead Sciences, Inc.
- 当前专利权人： Gilead Sciences, Inc.
- 当前专利权人地址： US CA Foster City
- 主分类号： A61K31/4985
- IPC分类号： A61K31/4985 ; C07D413/14 ; C07D498/14 ; A61K31/537 ; C07D471/22 ; A61K31/529 ; A61K31/551 ; A61K31/498 ; C07D471/18 ; A61K45/06 ; C07D498/18 ; C07D487/14 ; A61K31/553
![Substituted 3,4,5,6,8,10,14,14a-octahydro-2h-2,6-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazocines and methods for treating viral infections](/abs-image/US/2020/06/23/US10689399B2/abs.jpg.150x150.jpg)
摘要：
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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