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1.发明申请公开(公告)号：US20220167918A1
公开(公告)日：2022-06-02
申请号：US17651661
申请日：2022-02-18
发明人： Marissa A. Howard , Lance A. Liotta , Rachel Naidich , Matthew Luu Trang , Ish Sethi , Rebecca Woodhouse , Kshamata Neupane
摘要： A wearable device measures, tracks, and monitors a wearer's physical physiological conditions during a rehabilitation period. Metrics such as temperature, patellar shifting, limb circumference, and acceleration may be collected. Changes in monitored conditions may be assessed for detecting medical abnormalities which require specialized attention, including for example embolisms or infections. A networked communication system and various user interfaces may be used for medical support personnel and patients alike to stay updated with the patient's rehabilitation progress and to make adjustments in a patient's individual rehabilitation program.
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2.发明授权公开(公告)号：US12011291B2
公开(公告)日：2024-06-18
申请号：US17651661
申请日：2022-02-18
发明人： Marissa A. Howard , Lance A. Liotta , Rachel Naidich , Matthew Luu Trang , Ish Sethi , Rebecca Woodhouse , Kshamata Neupane
CPC分类号： A61B5/6828 , A61B5/0024 , A61B5/0053 , A61B5/015 , A61B5/1107 , A61B5/1126 , A61B5/4528 , A61B5/4585 , A61B5/4848 , A61B5/6824 , A61B5/6829 , A61B5/7275 , A61B5/746 , A61B5/0048 , A61B5/1114 , A61B5/112 , A61B5/4519 , A61B5/7465 , A61B2503/08 , A61B2503/10 , A61B2505/09 , A61B2562/0219 , A61B2562/0247 , A61B2562/0261 , A61B2562/0271 , A61H2230/08 , A61H2230/50
摘要： A wearable device measures, tracks, and monitors a wearer's physical physiological conditions during a rehabilitation period. Metrics such as temperature, patellar shifting, limb circumference, and acceleration may be collected. Changes in monitored conditions may be assessed for detecting medical abnormalities which require specialized attention, including for example embolisms or infections. A networked communication system and various user interfaces may be used for medical support personnel and patients alike to stay updated with the patient's rehabilitation progress and to make adjustments in a patient's individual rehabilitation program.
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公开(公告)号：US20240345105A1
公开(公告)日：2024-10-17
申请号：US18406908
申请日：2024-01-08
发明人： Lance A. Liotta , Alessandra Luchini Kunkel , Marissa Ashton Howard , Amanda Nicole Haymond Still , Ahana Byne , Paul Steven Russo
IPC分类号： G01N33/94
CPC分类号： G01N33/94
摘要： The present disclosure relates in certain aspects, to compositions and methods for stabilizing analytes of interest in an oral fluid. In another aspect, the present disclosure relates to sequestering and/or isolating analytes of interest from an oral fluid. In another aspect, the present disclosure relates to methods of detecting or quantifying the amount of an analyte of interest in an oral fluid. In another aspect, the present disclosure relates to devices and kits for the same. In certain embodiments, the analytes of interest are drugs of addiction, including tetrahydrocannabinol (THC).
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公开(公告)号：US09029076B2
公开(公告)日：2015-05-12
申请号：US13836995
申请日：2013-03-15
发明人： Virginia A. Espina , Lance A. Liotta , David Geho
摘要： This invention relates, e.g., to a composition that, at room temperature, when contacted with a sample comprising phosphoproteins, can fix and stabilize cellular phosphoproteins, preserve cellular morphology, and allow the sample to be frozen to generate a cryostat frozen section suitable for molecular analysis. The composition comprises (1) a fixative that stabilizes the proteins in the sample and that has a sufficient water content for a stabilizer and/or a permeability enhancing agent to be soluble therein; (2) a stabilizer, comprising (a) a kinase inhibitor and (b) a phosphatase inhibitor and, optionally, (c) a protease (e.g., proteinase) inhibitor; (3) a permeability enhancing agent; and (4) lactic acid. Methods and kits are described for preserving phosphoproteins, using such a composition. Also described are endogenous surrogate markers for monitoring protein degradation, including the loss of posttranslational modifications (such as phosphorylation), e.g. following removal of a cell or tissue from a subject; and exogenous molecular sentinels (e.g. phosphoproteins attached to magnetic nanoparticles) that allow one to evaluate the processing history of a cellular or tissue population sample.
摘要翻译： 本发明涉及例如在室温下与包含磷蛋白的样品接触时可以固定和稳定细胞磷酸蛋白的组合物，保留细胞形态，并允许样品冷冻以产生适于分子的低温恒温器冷冻切片 分析。 组合物包含（1）稳定样品中蛋白质并且具有足够的水含量的固定剂，用于稳定剂和/或渗透性增强剂可溶于其中; （2）稳定剂，其包含（a）激酶抑制剂和（b）磷酸酶抑制剂和任选的（c）蛋白酶（例如蛋白酶）抑制剂; （3）渗透增强剂; 和（4）乳酸。 描述了使用这种组合物来保存磷蛋白的方法和试剂盒。 还描述了用于监测蛋白质降解的内源替代标记，包括翻译后修饰（例如磷酸化）的丧失，例如， 从受试者中除去细胞或组织; 和外源性分子前哨蛋白（例如连接到磁性纳米颗粒的磷酸蛋白），其允许评价细胞或组织群体样品的加工历史。
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公开(公告)号：US20150118246A1
公开(公告)日：2015-04-30
申请号：US14477512
申请日：2014-09-04
IPC分类号： G01N33/574 , A61K39/395 , A61K31/506
CPC分类号： G01N33/57419 , A61K31/506 , A61K39/39558 , C07K16/22 , G01N33/57438 , G01N2800/52
摘要： Disclosed herein are: 1) methods for determining the appropriate drug therapy for a patient with colorectal cancer that has metastasized to the patient's liver and/or lung; 2) methods for treating such a patient; and 3) pharmaceutical compositions for such treatment.
摘要翻译： 本文公开的是：1）确定已经转移到患者的肝和/或肺的结肠直肠癌患者的适当药物治疗的方法; 2）治疗这种患者的方法; 和3）用于这种治疗的药物组合物。
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