公开(公告)号：US20220403034A1

公开(公告)日：2022-12-22

申请号：US17592227

申请日：2022-02-03

Applicant: GENENTECH, INC.

Inventor： Azra Hassanali ,  Romeo Maciuca ,  Meina Tao Tang ,  Swati Tole ,  Xiaohui Wei

IPC: C07K16/28 ,  A61K31/573 ,  A61K31/58 ,  A61K39/395

Abstract: Methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including Crohn's disease are provided. Also provided are methods of administering and dosing integrin beta7 antagonists, such as anti-integrin beta7 antibodies. In addition, methods of administrating and dosing such integrin beta7 antagonists to induce remission or to induce and maintain remission of Crohn's disease are provided.

公开(公告)号：US20180086833A1

公开(公告)日：2018-03-29

申请号：US15681881

申请日：2017-08-21

Applicant: Genentech, Inc.

Inventor： Azra Hassanali ,  Romeo Maciuca ,  Meina Tao Tang ,  Swati Tole ,  Xiaohui Wei

IPC: C07K16/28 ,  A61K39/395 ,  A61K31/573 ,  A61K31/58

CPC classification number: C07K16/2839 ,  A61K31/573 ,  A61K31/58 ,  A61K39/39541 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/56 ,  C07K2317/76

Abstract: Methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including Crohn's disease are provided. Also provided are methods of administering and dosing integrin beta7 antagonists, such as anti-integrin beta7 antibodies. In addition, methods of administrating and dosing such integrin beta7 antagonists to induce remission or to induce and maintain remission of Crohn's disease are provided.