公开(公告)号：US20030082651A1

公开(公告)日：2003-05-01

申请号：US09954736

申请日：2001-09-17

Applicant: GENENTECH, INC.

Inventor： Wei-Qiang Gao ,  Hartmut Koeppen ,  Sarajane Ross ,  Jianyong Shou

IPC: C12Q001/68 ,  G01N033/574 ,  A61K039/395

CPC classification number: A61K38/1709 ,  A61K2039/505 ,  G01N33/57434 ,  G01N2500/00

Abstract: The present invention is directed to methods of alleviating prostate disorders by activation of the Notch1 receptor. Also provided herein are methods for detecting and diagnosing prostate disorders, wherein the specific disorder is prostate cancer.

Abstract translation: 本发明涉及通过Notch1受体活化来减轻前列腺障碍的方法。 本文还提供了用于检测和诊断前列腺疾病的方法，其中特异性病症是前列腺癌。

公开(公告)号：US20030055224A1

公开(公告)日：2003-03-20

申请号：US09929769

申请日：2001-08-14

Applicant: GENENTECH, INC.

Inventor： Wei-Qiang Gao ,  Paul Polakis ,  Jianyong Shou ,  Victoria Smith ,  Robert Soriano ,  P. Mickey Williams ,  Thomas D. Wu ,  Zemin Zhang

IPC: C07K016/30 ,  G01N033/574 ,  A61K039/395

CPC classification number: C07K16/3069 ,  C07K14/4748 ,  C07K16/3046 ,  C07K2319/21 ,  C07K2319/30

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.