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公开(公告)号：US10273486B2
公开(公告)日：2019-04-30
申请号：US14483142
申请日：2014-09-10
Applicant: GENEART AG
Inventor： Frank Notka , Marcus Graf , Doris Baumann , Ralf Wagner , David Raab
IPC: C12N15/63 , C07K14/435
Abstract: The invention relates to nucleic acid modifications for a directed expression modulation by the targeted insertion or removal of CpG dinucleotides. The invention also relates to modified nucleic acids and expression vectors.
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