公开(公告)号：US10030071B2

公开(公告)日：2018-07-24

申请号：US14916943

申请日：2014-09-05

申请人： UNIVERSITY OF MIYAZAKI ,  FUJITA HEALTH UNIVERSITY ,  PERSEUS PROTEOMICS INC.

发明人： Kazuhiro Morishita ,  Kazuko Kaneda ,  Yoshikazu Kurosawa ,  Gene Kurosawa ,  Katsuyuki Mitomo ,  Katsushi Kouda ,  Yoshinori Ukai

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K16/46 ,  C07K16/28 ,  A61K31/365 ,  A61K31/704 ,  A61K31/7068 ,  A61K39/00

摘要： It is an object of the present invention to provide an anti-ITGA6/B4 human antibody, which specifically recognizes ITGA6B4 complex expressed on a cell membrane and inhibits the adhesion of the ITGA6B4 complex to laminin, so as to inhibit adhesion of cancer cells to a bone marrow niche, and which is also capable of remarkably enhancing the effects of an anticancer agent on an anticancer agent resistant strain. The present invention provides an antibody against integrin A6B4, wherein the antibody specifically recognizes a human integrin A6B4 complex and inhibits intercellular adhesion.

公开(公告)号：US09388249B2

公开(公告)日：2016-07-12

申请号：US14265416

申请日：2014-04-30

申请人： Fujita Health University

发明人： Atsushi Sugioka ,  Gene Kurosawa ,  Mariko Sumitomo ,  Yoshikazu Kurosawa

IPC分类号： A61K39/395 ,  C07K16/30 ,  C07K16/00 ,  C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  C12N15/113 ,  G01N33/574 ,  G01N33/68

CPC分类号： C07K16/30 ,  C07K16/005 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2863 ,  C07K16/2896 ,  C07K16/303 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C12N15/1138 ,  C12N2310/14 ,  G01N33/57492 ,  G01N33/6854

摘要： The present invention relates to an isolated antibody against HER1, an isolated antibody against CD147, an isolated antibody against CD73, and an isolated antibody against EpCAM; reagents and compositions including said antibodies; and uses of said reagents, compositions, and antibodies. The present invention also relates to nucleic acids and vectors expressing said antibodies. The invention further relates to transformants comprising said nucleic acids or vectors.

摘要翻译： 本发明涉及针对HER1的分离抗体，针对CD147的分离抗体，针对CD73的分离抗体和针对EpCAM的分离抗体; 包括所述抗体的试剂和组合物; 和所述试剂，组合物和抗体的用途。 本发明还涉及表达所述抗体的核酸和载体。 本发明还涉及包含所述核酸或载体的转化体。

公开(公告)号：US09273140B2

公开(公告)日：2016-03-01

申请号：US13891652

申请日：2013-05-10

申请人： FUJITA HEALTH UNIVERSITY ,  PERSEUS PROTEOMICS INC.

发明人： Yoshikazu Kurosawa ,  Maiko Kurosawa ,  Gene Kurosawa

IPC分类号： C07K16/30 ,  C12N15/13 ,  C12N15/85 ,  G01N33/68 ,  C07K16/28

CPC分类号： C07K16/30 ,  C07K16/28 ,  C07K2317/622 ,  G01N33/6893

摘要： To provide a method for detecting cellular DNA damage by specifically recognizing molecules responsive to DNA strand breaks. A method for detecting DNA damage in cells, which comprises administering in vivo, to cells, an antibody against a cell membrane surface antigen that is expressed in cells undergoing DNA strand breaks to a greater extent than in cells not undergoing DNA strand breaks in an environment that causes DNA damage, and analyzing the expression status of the cell membrane surface antigen.

摘要翻译： 提供通过特异性识别对DNA链断裂有反应的分子来检测细胞DNA损伤的方法。 一种用于检测细胞中DNA损伤的方法，其包括在体内向细胞施用针对细胞膜表面抗原的抗体，其在经历DNA链断裂的细胞中表达的程度大于在环境中不经历DNA链断裂的细胞中 导致DNA损伤，并分析细胞膜表面抗原的表达状态。