- 专利标题： Antibody which specifically reacts with human integrin A6B4
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申请号： US14916943申请日： 2014-09-05
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公开(公告)号： US10030071B2公开(公告)日： 2018-07-24
- 发明人: Kazuhiro Morishita , Kazuko Kaneda , Yoshikazu Kurosawa , Gene Kurosawa , Katsuyuki Mitomo , Katsushi Kouda , Yoshinori Ukai
- 申请人： UNIVERSITY OF MIYAZAKI , FUJITA HEALTH UNIVERSITY , PERSEUS PROTEOMICS INC.
- 申请人地址： JP Miyazaki-shi, Miyazaki JP Toyoake-shi, Aichi JP Tokyo
- 专利权人： UNIVERSITY OF MIYAZAKI,FUJITA HEALTH UNIVERSITY,PERSEUS PROTEOMICS INC.
- 当前专利权人： UNIVERSITY OF MIYAZAKI,FUJITA HEALTH UNIVERSITY,PERSEUS PROTEOMICS INC.
- 当前专利权人地址： JP Miyazaki-shi, Miyazaki JP Toyoake-shi, Aichi JP Tokyo
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 优先权： JP2013-183703 20130905
- 国际申请： PCT/JP2014/073507 WO 20140905
- 国际公布： WO2015/034052 WO 20150312
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/00 ; C07K16/46 ; C07K16/28 ; A61K31/365 ; A61K31/704 ; A61K31/7068 ; A61K39/00
摘要：
It is an object of the present invention to provide an anti-ITGA6/B4 human antibody, which specifically recognizes ITGA6B4 complex expressed on a cell membrane and inhibits the adhesion of the ITGA6B4 complex to laminin, so as to inhibit adhesion of cancer cells to a bone marrow niche, and which is also capable of remarkably enhancing the effects of an anticancer agent on an anticancer agent resistant strain. The present invention provides an antibody against integrin A6B4, wherein the antibody specifically recognizes a human integrin A6B4 complex and inhibits intercellular adhesion.
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