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公开(公告)号：US11439956B2
公开(公告)日：2022-09-13
申请号：US16864234
申请日：2020-05-01
发明人： Charles Heise , Tibor Nagy
摘要： Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means for mixing at least two liquids comprising a multiple inlet flow-controller, the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device configured in single-pass mode.
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公开(公告)号：US10934325B2
公开(公告)日：2021-03-02
申请号：US16068387
申请日：2016-12-19
发明人： Charles Heise , Tibor Nagy
IPC分类号： C07K1/34
摘要： A method of concentration of a liquid comprising a biomolecule is provided. The method comprises passing the liquid through a tangential flow filtration device under pressure, wherein the pressure applied is varied between at least a higher pressure and a lower pressure. Preferably, the variation in pressure is delivered by the use of a variable flow-controller, such as a valve.
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公开(公告)号：US20220333060A1
公开(公告)日：2022-10-20
申请号：US17634679
申请日：2020-08-06
发明人： Tibor Nagy , Jonathan Haigh , Charles Heise , Andrew Topping , James Pullen
摘要： A process for purifying a composition comprising water, a target substance, impurities and optionally cells, the process comprising the steps (A) and (B): (A) preparing a liquid feedstock by performing step (Ai) and/or (Aii) on the composition: (Ai) removing at least some of the cells from the composition; (Aii) concentrating the composition by removing water therefrom; and (B) passing the liquid feedstock through an apparatus comprising at least two processing units, each such unit producing a product stream containing purified target substance and optionally a waste stream comprising at least some of the impurities, wherein each unit comprises specified components (i) to (v). The units may be essentially the same except for a device they contain, leading to advantages in terms of simplicity, cost and ease of operation, lower risk of operator error, easier maintenance and lower inventory of spare parts.
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公开(公告)号：US20190009215A1
公开(公告)日：2019-01-10
申请号：US16068465
申请日：2016-12-19
发明人： Charles Heise , Tibor Nagy
摘要： Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means (3) for mixing at least two liquids comprising a multiple inlet flow-controller (2), the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device (1) configured in single-pass mode.
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公开(公告)号：US11685765B2
公开(公告)日：2023-06-27
申请号：US17152874
申请日：2021-01-20
发明人： Charles Heise , Tibor Nagy
IPC分类号： C07K1/34
CPC分类号： C07K1/34
摘要： A method of concentration of a liquid comprising a biomolecule is provided. The method comprises passing the liquid through a tangential flow filtration device under pressure, wherein the pressure applied is varied between at least a higher pressure and a lower pressure. Preferably, the variation in pressure is delivered by the use of a variable flow-controller, such as a valve.
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公开(公告)号：US20220275024A1
公开(公告)日：2022-09-01
申请号：US17634672
申请日：2020-08-06
发明人： Tibor Nagy , Jonathan Haigh , Charles Heise , Andrew Topping , James Pullen
IPC分类号： C07K1/36 , C07K1/34 , C07K1/22 , C07K1/18 , C07K16/06 , B01D15/14 , B01D15/18 , B01D61/14 , B01D15/38 , B01D15/36
摘要： A process for purifying a liquid feedstock comprising a monoclonal antibody and impurities, the process comprising passing the liquid feedstock through an apparatus comprising at least two processing units, each such unit producing a product stream containing purified monoclonal antibody and optionally a waste stream comprising at least some of the impurities, wherein each unit comprises specified components (i) to (v) which include a multiple inlet flow-controller comprising two or more variable flow inlet valves for in situ production of a bioprocessing liquid by combining at least two liquids in a desired ratio. One of the units performs chromatography and another performs viral inactivation. The units may be essentially the same except for a device they contain, leading to advantages in terms of simplicity, cost and ease of operation, lower risk of operator error, easier maintenance and lower inventory of spare parts.
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公开(公告)号：US20210033574A1
公开(公告)日：2021-02-04
申请号：US16969690
申请日：2019-02-11
发明人： Charles Heise , Jonathan Haigh , Tibor Nagy , James Pullen , Andrew Topping
摘要： Apparatus for processing a liquid comprising a target substance, preferably a biomolecule, is provided. The apparatus comprises at least a first and a second means for carrying out a unit operation, each means for carrying out a unit operation comprising a feed for a liquid in fluid connection with the inlet of a flow-controller comprising a variable flow inlet valve and an outlet, wherein at least one of the means for carrying out a unit operation comprises feeds for at least two liquids, the feeds being in fluid connection with the inlets of a multiple inlet flow-controller comprising two or more variable flow inlet valves for dosing the at least two liquids, the flow-controller also comprising an outlet; a feed for a liquid feedstock comprising the target substance in fluid connection with the outlet from the flow-controller thereby to enable combination of the feed for a liquid comprising the target substance with the mixed bioprocessing liquids to produce a device feed; a device for achieving a processing operation comprising a device inlet and a device outlet, the device inlet being in fluid connection with the device feed; and a means for imparting flow through the flow controller and from the feed for the liquid feedstock through the processing device via the device inlet; and wherein the feed for a liquid feedstock comprising the target substance for the second means for carrying out a unit operation comprises the outlet from the first means for carrying out a unit operation.
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公开(公告)号：US20190010189A1
公开(公告)日：2019-01-10
申请号：US16068387
申请日：2016-12-19
发明人： Charles Heise , Tibor Nagy
IPC分类号： C07K1/34
摘要： A method of concentration of a liquid comprising a biomolecule is provided. The method comprises passing the liquid through a tangential flow filtration device under pressure, wherein the pressure applied is varied between at least a higher pressure and a lower pressure. Preferably, the variation in pressure is delivered by the use of a variable flow-controller, such as a valve.
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公开(公告)号：US20220325231A1
公开(公告)日：2022-10-13
申请号：US17634692
申请日：2020-08-06
发明人： Tibor Nagy , Jonathan Haigh , Charles Heise , Andrew Topping , James Pullen
摘要： Apparatus for purifying a liquid comprising a target substance comprising at least two units arranged in series such that the feed stream of the second and any subsequent units comprises the product stream from a downstream unit, wherein each unit comprises specified components (i) to (vi), including a a switchable bypass assembly. Also claimed are the units and a flowpath assembly. The units may be essentially the same except for a device they contain, leading to advantages in terms of simplicity, cost and ease of operation, lower risk of operator error, easier maintenance and lower inventory of spare parts.
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公开(公告)号：US20220001342A1
公开(公告)日：2022-01-06
申请号：US17293541
申请日：2019-11-13
发明人： Charles Heise
IPC分类号： B01F5/06
摘要： A static mixing apparatus for mixing a fluid, preferably a liquid is provided. The mixer comprises a plurality of chambers (5, 8, 12, 15) in series, the first chamber (5) of the series comprising a fluid inlet (4), and the final chamber (15) of the series comprising a fluid outlet (16), each chamber other than the final chamber in the series being in fluid connection with a subsequent chamber, the fluid connection comprising a plurality of orifices (7, 10, 11, 14) dispersed along a direction of flow, the nearest point to the fluid inlet of each subsequent orifice to the inlet overlapping with the furthest point from the fluid inlet of the previous orifice, and being off-set along the direction of flow from the previous orifice.
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