公开(公告)号：US20230238077A1

公开(公告)日：2023-07-27

申请号：US18128557

申请日：2023-03-30

Applicant: Fresenius Medical Care Holdings, Inc.

Inventor： Xia Tao ,  Vaibhav Maheshwari ,  Peter Kotanko ,  Stephan Thijssen ,  Nadja Grobe

IPC: G16B15/30 ,  A61M1/16 ,  G16H20/17 ,  G16H20/40 ,  G16H50/50 ,  G16B5/20 ,  G16C20/30

CPC classification number: G16B15/30 ,  A61M1/1613 ,  A61M1/1676 ,  G16H20/17 ,  G16H20/40 ,  G16H50/50 ,  G16B5/20 ,  G16C20/30 ,  G16C20/64

Abstract: Systems, methods, and/or apparatuses may be operative to perform a dialysis process that includes a displacer infusion process. In one embodiment, a method for determining a displacer compound may include constructing a plurality of target protein quantitative structure-activity relationship (QSAR) models, one for each of the plurality of binding sites, analyzing a set of candidate compounds using the plurality of QSAR models to determine a set of at least one potential compound with an affinity for binding to each of the plurality of binding sites, and selecting at least one displacer compound from the set of at least one potential compound. Other embodiments are described.

公开(公告)号：US20220241476A1

公开(公告)日：2022-08-04

申请号：US17587168

申请日：2022-01-28

Applicant: Fresenius Medical Care Holdings, Inc.

Inventor： Peter Kotanko ,  Xia Tao ,  Nadja Grobe ,  Gabriela Dias ,  Zahin Haq ,  Stephan Thijssen

IPC: A61M1/16 ,  A61M1/28 ,  G16H10/60 ,  A61B5/00

Abstract: Methods, apparatuses, and systems for determining patient dialysis profiles, for example, of peritoneal transport status or disease progression, are described. For example, in one embodiment, a method of determining a patient profile of a dialysis patient may include obtaining a volume of fluid associated with the dialysis patient, generating patient information via fluorescence analysis of the patient fluid, and determining the patient profile based on evaluating the patient information with a profile library, the patient profile comprising at least one of a peritoneal transport status classification or a disease progression. Other embodiments are described.

公开(公告)号：US11640846B2

公开(公告)日：2023-05-02

申请号：US17162030

申请日：2021-01-29

Applicant: Fresenius Medical Care Holdings, Inc.

Inventor： Xia Tao ,  Vaibhav Maheshwari ,  Peter Kotanko ,  Stephan Thijssen ,  Nadja Grobe

IPC: G16B15/30 ,  A61M1/16 ,  G16H20/17 ,  G16H20/40 ,  G16H50/50 ,  G16B5/20 ,  G16C20/30 ,  G16C20/64

Abstract: Systems, methods, and/or apparatuses may be operative to perform a dialysis process that includes a displacer infusion process. In one embodiment, a method for determining a displacer compound may include constructing a plurality of target protein quantitative structure-activity relationship (QSAR) models, one for each of the plurality of binding sites, analyzing a set of candidate compounds using the plurality of QSAR models to determine a set of at least one potential compound with an affinity for binding to each of the plurality of binding sites, and selecting at least one displacer compound from the set of at least one potential compound. Other embodiments are described.

公开(公告)号：US20210241848A1

公开(公告)日：2021-08-05

申请号：US17162030

申请日：2021-01-29

Applicant: Fresenius Medical Care Holdings, Inc.

Inventor： Xia Tao ,  Vaibhav Maheshwari ,  Peter Kotanko ,  Stephan Thijssen ,  Nadja Grobe

IPC: G16B15/30 ,  G16B5/20 ,  A61M1/16 ,  G16H20/40 ,  G16H50/50 ,  G16H20/17

Abstract: Systems, methods, and/or apparatuses may be operative to perform a dialysis process that includes a displacer infusion process. In one embodiment, a method for determining a displacer compound may include constructing a plurality of target protein quantitative structure-activity relationship (QSAR) models, one for each of the plurality of binding sites, analyzing a set of candidate compounds using the plurality of QSAR models to determine a set of at least one potential compound with an affinity for binding to each of the plurality of binding sites, and selecting at least one displacer compound from the set of at least one potential compound. Other embodiments are described.

公开(公告)号：US20210215666A1

公开(公告)日：2021-07-15

申请号：US16739366

申请日：2020-01-10

Applicant: FRESENIUS MEDICAL CARE HOLDINGS, INC.

Inventor： Peter Kotanko ,  Xia Tao ,  Mia G. Garbaccio ,  Stephan Thijssen ,  Nadja Grobe ,  Leticia M. Tapia Silva

IPC: G01N33/487 ,  A61M1/28 ,  C12Q1/06 ,  G01N21/59

Abstract: An apparatus used in analyzing spent dialysate includes at least a first surface configured to accommodate a dialysate drain bag in a first predetermined position, and at least a second surface configured to accommodate a dialysate analysis device in a second predetermined position, such that when the dialysate drain bag is in the first predetermined position and the dialysate analysis device is in the second predetermined position, a light sensor of the dialysate analysis device is positioned to sense light passing through the dialysate drain bag.

公开(公告)号：US12036344B2

公开(公告)日：2024-07-16

申请号：US17097299

申请日：2020-11-13

Applicant: FRESENIUS MEDICAL CARE HOLDINGS, INC.

Inventor： Peter Kotanko ,  Xia Tao ,  Mia G. Garbaccio ,  Jeffrey Hymes ,  Stephan Thijssen ,  Nadja Grobe ,  Leticia M. Tapia Silva ,  Dinesh K. Chatoth

IPC: A61M1/28 ,  A61M1/00 ,  A61M1/16

CPC classification number: A61M1/1619 ,  A61M1/1643 ,  A61M1/28 ,  A61M1/69 ,  A61M2202/0439 ,  A61M2202/0486 ,  A61M2205/18 ,  A61M2205/3327 ,  A61M2205/3592 ,  A61M2205/583 ,  A61M2205/587

Abstract: An apparatus used in analyzing spent dialysate includes: at least one surface configured to accommodate a dialysate drain bag or drain line in a predetermined position; a light source positioned to emit light through the dialysate drain bag or drain line; and a light sensor positioned to sense light emitted by the light source through the dialysate drain bag or drain line.

公开(公告)号：US20230405201A1

公开(公告)日：2023-12-21

申请号：US18032931

申请日：2021-11-12

Applicant: FRESENIUS MEDICAL CARE HOLDINGS, INC. ,  FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

Inventor： Peter Kotanko ,  Nadja Grobe ,  Christoph Zaba ,  David Joerg ,  Frank Gebauer

IPC: A61M1/34

CPC classification number: A61M1/3486 ,  A61M2202/0498

Abstract: The described technology may include treatment processes to increase the red blood cell (RBC) population of individuals, particularly chronic kidney disease (CKD) patients with renal anemia, by reducing an amount of Piezo1 chemical agonists in the blood of patients. In one embodiment, a method of treating a patient with renal anemia may include increasing RBC lifespan of an RBC population of the patient via reduction of a Piezo1 channel activation duration of at least a portion of the RBC population by reducing an amount of a target uremic compound in the blood of the patient, the target uremic compound having a form that prolongs the Piezo1 channel activation duration, wherein the amount of the target uremic compound may be reduced via selectively removing at least a portion of the target uremic compound from the blood of the patient. Other embodiments are described.

公开(公告)号：US20220152282A1

公开(公告)日：2022-05-19

申请号：US17097299

申请日：2020-11-13

Applicant: FRESENIUS MEDICAL CARE HOLDINGS, INC.

Inventor： Peter Kotanko ,  Xia Tao ,  Mia G. Garbaccio ,  Jeffrey Hymes ,  Stephan Thijssen ,  Nadja Grobe ,  Leticia M. Tapia Silva ,  Dinesh K. Chatoth

IPC: A61M1/16 ,  A61M1/28 ,  A61M1/00

Abstract: An apparatus used in analyzing spent dialysate includes: at least one surface configured to accommodate a dialysate drain bag or drain line in a predetermined position; a light source positioned to emit light through the dialysate drain bag or drain line; and a light sensor positioned to sense light emitted by the light source through the dialysate drain bag or drain line.

公开(公告)号：US12228564B2

公开(公告)日：2025-02-18

申请号：US16739366

申请日：2020-01-10

Applicant: FRESENIUS MEDICAL CARE HOLDINGS, INC.

Inventor： Peter Kotanko ,  Xia Tao ,  Mia G. Garbaccio ,  Stephan Thijssen ,  Nadja Grobe ,  Leticia M. Tapia Silva

IPC: A61M1/28 ,  C12Q1/06 ,  G01N21/59 ,  G01N33/487

Abstract: An apparatus used in analyzing spent dialysate includes at least a first surface configured to accommodate a dialysate drain bag in a first predetermined position, and at least a second surface configured to accommodate a dialysate analysis device in a second predetermined position, such that when the dialysate drain bag is in the first predetermined position and the dialysate analysis device is in the second predetermined position, a light sensor of the dialysate analysis device is positioned to sense light passing through the dialysate drain bag.

公开(公告)号：US20240316253A1

公开(公告)日：2024-09-26

申请号：US18733259

申请日：2024-06-04

Applicant: FRESENIUS MEDICAL CARE HOLDINGS, INC.

Inventor： Peter Kotanko ,  Xia Tao ,  Mia G. Garbaccio ,  Jeffrey Hymes ,  Stephan Thijssen ,  Nadja Grobe ,  Leticia M. Tapia Silva ,  Dinesh K. Chatoth

IPC: A61M1/16 ,  A61M1/00 ,  A61M1/28

CPC classification number: A61M1/1619 ,  A61M1/1643 ,  A61M1/28 ,  A61M1/69 ,  A61M2202/0439 ,  A61M2202/0486 ,  A61M2205/18 ,  A61M2205/3327 ,  A61M2205/3592 ,  A61M2205/583 ,  A61M2205/587

Abstract: An apparatus used in analyzing spent dialysate includes: at least one surface configured to accommodate a dialysate drain bag or drain line in a predetermined position; a light source positioned to emit light through the dialysate drain bag or drain line; and a light sensor positioned to sense light emitted by the light source through the dialysate drain bag or drain line.