公开(公告)号：US11534499B2

公开(公告)日：2022-12-27

申请号：US16304580

申请日：2017-05-25

Applicant: Evox Therapeutics Ltd. ,  Oxford University Innovation Limited

Inventor： Justin Hean ,  Imre Mager ,  Matthew Wood ,  Samir El Andaloussi ,  Oscar Wiklander ,  Joel Nordin

IPC: A61K48/00 ,  A61K47/65 ,  A61K41/00 ,  A61K47/64 ,  A61K47/00 ,  A61K9/127

Abstract: The present invention pertains to an inventive release mechanism for extracellular vesicle (EV)-mediated intracellular and intramembrane delivery of therapeutic polypeptides. More specifically, the invention relates to EVs comprising polypeptide constructs which comprise a therapeutic polypeptide releasably attached to an exosomal polypeptide. Furthermore, the present invention pertains to manufacturing methods, pharmaceutical compositions, medical uses and applications, and various other embodiments related to the inventive EVs.

公开(公告)号：US11649272B2

公开(公告)日：2023-05-16

申请号：US16795429

申请日：2020-02-19

Applicant: Evox Therapeutics Ltd.

Inventor： Samir El Andaloussi ,  Oscar Wiklander ,  Joel Nordin ,  Edvard Smith ,  Karl-Henrik Grinnemo ,  Oscar Simonson

IPC: A61K47/69 ,  A61K47/62 ,  A61K9/00 ,  A61K38/17 ,  A61K38/00 ,  C07K14/705 ,  F01C21/10 ,  F01C1/344

CPC classification number: C07K14/70578 ,  A61K9/00 ,  A61K38/177 ,  A61K47/62 ,  A61K47/6911 ,  C07K14/705 ,  C07K14/70596 ,  F01C1/3442 ,  F01C21/102 ,  A61K38/00 ,  C07K2319/00

Abstract: The present invention pertains to inter alia methods for purifying extracellular vesicles including exposing a sample comprising at least one extracellular vesicle to ultrafiltration; and exposing the sample following the ultrafiltration in step (i) to size exclusion liquid chromatography.

公开(公告)号：US11274139B2

公开(公告)日：2022-03-15

申请号：US14784015

申请日：2014-04-10

Applicant: Evox Therapeutics Ltd.

Inventor： Samir El Andaloussi ,  Oscar Wiklander ,  Joel Nordin ,  Edvard Smith ,  Karl-Henrik Grinnemo ,  Oscar Simonson

IPC: A61K9/00 ,  A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C07K1/00 ,  C07K14/705 ,  F01C21/10 ,  F01C1/344 ,  A61K47/69 ,  A61K47/62 ,  A61K38/17

Abstract: The present invention pertains to inter alia therapeutic delivery vesicles, for instance exosomes or microvesicles, comprising polypeptide constructs, methods for producing said therapeutic delivery vesicles, pharmaceutical compositions and medical uses thereof. The therapeutic polypeptide constructs comprised in the extracellular delivery vesicles enable sequestering target molecules of interest, to treat e.g. neuro-inflammatory diseases and cancer.