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公开(公告)号：US06211370B1
公开(公告)日：2001-04-03
申请号：US09255480
申请日：1999-02-23
IPC分类号： C07D30918
CPC分类号： C07B37/02 , C07B53/00 , C07D309/18 , C07D309/32
摘要： The present invention relates to a process for stereoselective cycloaddition reactions which generally comprises a cycloaddition reaction between a pair of substrates, each either chiral or prochiral, that contain reactive &pgr;-systems, in the presence of a non-racemic chiral catalyst, to produce a stereoisomerically enriched product. The present invention also relates to novel asymmetric catalyst complexes comprising a metal and an asymmetric tridentate ligand.
摘要翻译： 本发明涉及一种用于立体选择性环加成反应的方法，其通常包括在非外消旋手性催化剂存在下含有反应性π系的一对底物之间的环加成反应（各自含有手性或前手性的），以产生 立体异构富集产物。 本发明还涉及包含金属和不对称三齿配体的新的不对称催化剂络合物。
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公开(公告)号：US6130340A
公开(公告)日：2000-10-10
申请号：US6104
申请日：1998-01-13
申请人： Eric N. Jacobsen , Scott E. Schaus
发明人： Eric N. Jacobsen , Scott E. Schaus
IPC分类号： C07B37/02 , C07B53/00 , C07D309/18 , C07D309/32 , C07D327/06 , C07D335/02
CPC分类号： C07B37/02 , C07B53/00 , C07D309/18 , C07D309/32
摘要： The present invention relates to a process for stereoselective cycloaddition reactions which generally comprises a cycloaddition reaction between a pair of chiral or prochiral substrates that contain reactive .pi.-systems, in the present of a non-racemic chiral catalyst, to produce a stereoisomerically enriched product.
摘要翻译： 本发明涉及一种用于立体选择性环加成反应的方法，其通常包含在非外消旋手性催化剂存在下含有反应性π-系统的一对手性或前置手性底物之间的环加成反应，以产生立体异构体富集的产物。
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公开(公告)号：US06369223B2
公开(公告)日：2002-04-09
申请号：US09755612
申请日：2001-01-04
IPC分类号： C07D28515
CPC分类号： C07B37/02 , C07B53/00 , C07D309/18 , C07D309/32
摘要： The present invention relates to a process for stereoselective cycloaddition reactions which generally comprises a cycloaddition reaction between a pair of substrates, each either chiral or prochiral, that contain reactive &pgr;-systems, in the presence of a non-racemic chiral catalyst, to produce a stereoisomerically enriched product. The present invention also relates to novel asymmetric catalyst complexes comprising a metal and an asymmetric tridentate ligand.
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公开(公告)号：US20100234348A1
公开(公告)日：2010-09-16
申请号：US12376288
申请日：2007-08-02
申请人： Guillaume Cottarel , Timothy S. Gardner , Xiaoguang Lei , John Porco , Scott E. Schaus , Jamey Wierzbowski , Kollol Pal
发明人： Guillaume Cottarel , Timothy S. Gardner , Xiaoguang Lei , John Porco , Scott E. Schaus , Jamey Wierzbowski , Kollol Pal
IPC分类号： A61K31/4035 , C07D405/08 , C07D487/04 , C07D498/06 , C07C69/00 , C07D231/56 , A61K31/5025 , A61K31/553 , A61K31/22 , A61K31/416 , C12Q1/18 , C12Q1/68 , A61P31/00
CPC分类号： C07D405/04 , C07B2200/07 , C07C69/14 , C07D231/56 , C07D241/44 , C07D261/16 , C07D277/74 , C07D307/68 , C07D311/16 , C07D311/30 , C07D311/32 , C07D405/06 , C07D487/04 , C07D495/04 , C07J63/008 , C12Q1/18
摘要： The present invention provides compounds that potentiate the activity of antibiotic agents, particularly quinolones such as norflaxin. The invention further provides compositions, e.g., pharmaceutical compositions, comprising the inventive compounds. The invention also provides compositions comprising an antibiotic (e.g., a quinolone) and a compound that potentiates activity of the antibiotic. The invention further provides methods of treating a subject comprising administering any of the inventive compounds or compositions to the subject. The invention also provides screening methods to identify compounds that potentiate the activity of an antibiotic, e.g., a quinolone.
摘要翻译： 本发明提供了增强抗生素剂，特别是喹诺酮类如诺氟沙星的活性的化合物。 本发明还提供包含本发明化合物的组合物，例如药物组合物。 本发明还提供包含抗生素（例如喹诺酮）和增强抗生素活性的化合物的组合物。 本发明还提供了治疗受试者的方法，包括向受试者施用任何本发明化合物或组合物。 本发明还提供了鉴定增强抗生素例如喹诺酮活性的化合物的筛选方法。
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