公开(公告)号：US20240358845A1

公开(公告)日：2024-10-31

申请号：US18560080

申请日：2022-05-09

申请人： Entrada Therapeutics, Inc.

发明人： Ziqing Qian ,  Patrick Dougherty ,  Mahboubeh Kheirabadi ,  Haoming Liu ,  Xiulong Shen ,  Xiang Li

IPC分类号： A61K47/64 ,  A61K31/7088 ,  A61K38/00 ,  A61P21/00 ,  C07K7/06 ,  C07K7/64 ,  C07K19/00 ,  C12N15/113

CPC分类号： A61K47/6455 ,  A61K31/7088 ,  A61P21/00 ,  C07K7/06 ,  C07K7/64 ,  C07K19/00 ,  C12N15/113 ,  A61K38/00 ,  C12N2310/11 ,  C12N2310/3513

摘要： Provided herein are compounds that include a cyclic cell penetrating peptide, a therapeutic moiety and a modulatory peptide, wherein the modulatory peptide modulates the tissue distribution and/or retention of the compound in vivo. Also provide herein are methods of modulating tissue distribution and/or retention of intracellular therapeutics using the aforementioned compounds.

公开(公告)号：US20230020092A1

公开(公告)日：2023-01-19

申请号：US17757421

申请日：2020-12-21

申请人： Entrada Therapeutics, Inc.

发明人： Ziqing Qian ,  Xiang Li ,  Mahboubeh Kheirabadi ,  Mohanraj Dhanabal ,  Haoming Liu ,  Xiulong Shen ,  Kimberli Kamer ,  Natarajan Sethuraman

IPC分类号： C07K7/64 ,  C12N15/113

摘要： Provided herein are compounds comprising cyclic cell penetrating peptides and antisense compounds. Also provided herein are methods of modulating splicing, inhibiting or regulating translation, mediating degradation, blocking expansions of nucleotide repeats, and treating disease using the aforementioned compounds.

公开(公告)号：US20240245790A1

公开(公告)日：2024-07-25

申请号：US18506057

申请日：2023-11-09

申请人： Entrada Therapeutics, Inc.

发明人： Ziqing Qian ,  Patrick Dougherty ,  Mahboubeh Kheirabadi ,  Haoming Liu ,  Xiulong Shen

IPC分类号： A61K47/64 ,  A61K47/54 ,  A61K47/60

CPC分类号： A61K47/64 ,  A61K47/545 ,  A61K47/60

摘要： The present disclosure is directed to cell penetrating peptides, including cyclic cell penetrating peptides with high cytosolic delivery efficiency and reduced toxicity that are able to effectively deliver cargo inside a cell to treat a variety of conditions and diseases.