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公开(公告)号：US20230097440A1
公开(公告)日：2023-03-30
申请号：US17970293
申请日：2022-10-20
Applicant: ENDECE LLC
Inventor： James G. Yarger
Abstract: Methods for modulating lipoprotein lipase (LPL) and Apoliprotein C2 (ApoC2) expression and/or activity in the treatment of peripheral and central nervous system tissue disease states with C-6 substituted estradiol derivatives are presented herein.
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公开(公告)号：US10723757B2
公开(公告)日：2020-07-28
申请号：US16241477
申请日：2019-01-07
Applicant: Endece LLC
Inventor： James G. Yarger
Abstract: Disclosed are compounds of the formula: and the respective enantiomers, stereochemical isomers, hydrates, solvates, tautomers and pharmaceutically acceptable salts of such compounds; which can be useful in the treatment of various types of cancer.
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Patent Agency Ranking
3.发明授权6-substituted demethyl-estradiol derivatives as selective ER-β agonists 有权6-取代的脱甲基 - 雌二醇衍生物作为选择性ER-β激动剂公开(公告)号：US09422324B2
公开(公告)日：2016-08-23
申请号：US14320110
申请日：2014-06-30
Applicant: Endece, LLC
Inventor： James G. Yarger , Steven H. Nye
CPC classification number: C07J1/007 , A61K31/56 , C07J1/0059 , C07J1/0074 , C07J17/00 , C07J31/006 , C07J41/0016 , C07J41/0044 , C07J51/00
Abstract: Disclosed herein are 6-substituted 13-demethyl-estradiol derivatives as selective ERβ agonists. Also disclosed is a method for treating pain by administering these 6-substituted 13-demethyl-estradiol derivatives.
Abstract translation: 本文公开了作为选择性ERβ激动剂的6-取代的13-去甲基 - 雌二醇衍生物。 还公开了通过施用这些6-取代的13-去甲基 - 雌二醇衍生物来治疗疼痛的方法。
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公开(公告)号：US20190135853A1
公开(公告)日：2019-05-09
申请号：US16241477
申请日：2019-01-07
Applicant: Endece LLC
Inventor： James G. Yarger
Abstract: Disclosed are compounds of the formula: and the respective enantiomers, stereochemical isomers, hydrates, solvates, tautomers and pharmaceutically acceptable salts of such compounds; which can be useful in the treatment of various types of cancer.
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5.发明申请6-Substituted Estradiol Derivatives for the Treatment of Alzheimer's Disease 审中-公开6-取代雌二醇衍生物治疗阿尔茨海默病公开(公告)号：US20150265630A1
公开(公告)日：2015-09-24
申请号：US14663043
申请日：2015-03-19
Applicant: Endece LLC
Inventor： James G. Yarger , Steven H. Nye
IPC: A61K31/565
CPC classification number: A61K31/565
Abstract: Disclosed is a method of treating Alzheimer's Disease with 6-substituted estradiol compounds of the formula The methods can be used to treat a variety of diseases related to the up-regulation of lipoprotein lipase or apolipoprotein C2.
Abstract translation: 公开了一种用下式的6-取代雌二醇化合物治疗阿尔茨海默病的方法。该方法可用于治疗与脂蛋白脂肪酶或载脂蛋白C2上调相关的多种疾病。
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公开(公告)号：US20210024568A1
公开(公告)日：2021-01-28
申请号：US16936705
申请日：2020-07-23
Applicant: ENDECE LLC
Inventor： James G. Yarger
Abstract: Methods for modulating lipoprotein lipase (LPL) and Apoliprotein C2 (ApoC2) expression and/or activity in the treatment of peripheral and central nervous system tissue disease states with C-6 substituted estradiol derivatives are presented herein.
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公开(公告)号：US09636348B2
公开(公告)日：2017-05-02
申请号：US15179349
申请日：2016-06-10
Applicant: Endece LLC
Inventor： James G. Yarger , Steven H. Nye
IPC: A61K31/568 , A61K31/5685 , A61K31/565 , A61K31/57 , A61K31/566 , A61K45/06
CPC classification number: A61K31/565 , A61K31/566 , A61K31/568 , A61K31/5685 , A61K45/06 , A61K2300/00
Abstract: Disclosed is a method of remyelinating axons with 6-substituted estradiol compounds of the formula The methods can be used to treat a variety of demyelinating diseases.
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