公开(公告)号：US20220112255A1

公开(公告)日：2022-04-14

申请号：US17559430

申请日：2021-12-22

申请人： Eli Lilly and Company

发明人： Jonathan Wesley Day ,  Josef George Heuer ,  Avinash Muppidi ,  Wei Ni ,  James David Pancook

IPC分类号： C07K14/475 ,  A61P9/04

摘要： The present invention relates to neuregulin (NRG) 4 compounds and methods of treatment with NRG4 compounds.

公开(公告)号：US11242370B2

公开(公告)日：2022-02-08

申请号：US16835787

申请日：2020-03-31

申请人： Eli Lilly and Company

发明人： Jonathan Wesley Day ,  Josef George Heuer ,  Avinash Muppidi ,  Wei Ni ,  James David Pancook

IPC分类号： C07K14/475 ,  A61P9/04 ,  A61K38/00 ,  A61M5/142

摘要： The present invention relates to neuregulin (NRG) 4 compounds and methods of treatment with NRG4 compounds.

公开(公告)号：US20240316154A1

公开(公告)日：2024-09-26

申请号：US18259500

申请日：2022-02-01

申请人： Eli Lilly and Company

发明人： Andrea Ferrante ,  Josef George Heuer ,  Stacey Lynn Lee ,  Petra Verdino

IPC分类号： A61K38/26 ,  A61K38/18 ,  A61K38/20 ,  A61K38/22 ,  A61K45/06 ,  C07K14/00

CPC分类号： A61K38/26 ,  A61K38/1883 ,  A61K38/2013 ,  A61K38/2221 ,  A61K45/06 ,  C07K14/00

摘要： The disclosure relates generally to biology and medicine, and more particularly it relates to compounds acting as half-life (t½)-extending moieties for use with therapeutics, especially for improving t½ of biological-based therapeutics (i.e., biotherapeutics or biologics). The disclosure further relates to fusions and conjugates that include one or more of the compounds acting as t½-extending moieties, as well as pharmaceutical compositions including the same and their use in treating various conditions, diseases or disorders.