公开(公告)号：US20220112255A1

公开(公告)日：2022-04-14

申请号：US17559430

申请日：2021-12-22

申请人： Eli Lilly and Company

发明人： Jonathan Wesley Day ,  Josef George Heuer ,  Avinash Muppidi ,  Wei Ni ,  James David Pancook

IPC分类号： C07K14/475 ,  A61P9/04

摘要： The present invention relates to neuregulin (NRG) 4 compounds and methods of treatment with NRG4 compounds.

公开(公告)号：US20210115100A1

公开(公告)日：2021-04-22

申请号：US16608015

申请日：2018-04-20

申请人： ELI LILLY AND COMPANY

发明人： James David Pancook ,  Scott William Rowlinson ,  Louis Frank Stancato

IPC分类号： C07K14/51 ,  A61P35/00 ,  C07K16/28 ,  A61K45/06

摘要： The present invention relates to novel variants of human BMP7 protein. The invention embodies vectors and host cells for the propagation of nucleic acid sequences encoding said proteins and the production thereof. Also disclosed are methods for the treatment of cancer, cartilage damage and degeneration, pain associated with osteoarthritis, or bone healing.

公开(公告)号：US11466066B2

公开(公告)日：2022-10-11

申请号：US16608015

申请日：2018-04-20

申请人： ELI LILLY AND COMPANY

发明人： James David Pancook ,  Scott William Rowlinson ,  Louis Frank Stancato

IPC分类号： C07K14/51 ,  A61P35/00 ,  A61K45/06 ,  C07K16/28 ,  A61K38/00 ,  A61N5/00

摘要： The present invention relates to novel variants of human BMP7 protein. The invention embodies vectors and host cells for the propagation of nucleic acid sequences encoding said proteins and the production thereof. Also disclosed are methods for the treatment of cancer, cartilage damage and degeneration, pain associated with osteoarthritis, or bone healing.

公开(公告)号：US11242370B2

公开(公告)日：2022-02-08

申请号：US16835787

申请日：2020-03-31

申请人： Eli Lilly and Company

发明人： Jonathan Wesley Day ,  Josef George Heuer ,  Avinash Muppidi ,  Wei Ni ,  James David Pancook

IPC分类号： C07K14/475 ,  A61P9/04 ,  A61K38/00 ,  A61M5/142

摘要： The present invention relates to neuregulin (NRG) 4 compounds and methods of treatment with NRG4 compounds.