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    1,4-Dihydropyridine derivatives substituted in the 2 position, and their use as medicaments
    6.
    发明授权
    1,4-Dihydropyridine derivatives substituted in the 2 position, and their use as medicaments 失效

    公开(公告)号：US4188395A

    公开(公告)日：1980-02-12

    申请号：US856559

    申请日：1977-12-01

    申请人： Friedrich Bossert ,  Egbert Wehinger ,  Horst Meyer ,  Arend Heise ,  Stanislav Kazda ,  Kurt Stoepel ,  Robertson Towart ,  Wulf Vater ,  Klaus Schlossmann

    发明人： Friedrich Bossert ,  Egbert Wehinger ,  Horst Meyer ,  Arend Heise ,  Stanislav Kazda ,  Kurt Stoepel ,  Robertson Towart ,  Wulf Vater ,  Klaus Schlossmann

    IPC分类号： A61K31/4427 ,  A61K31/455 ,  A61P3/06 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D211/90 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D213/55 ,  A61K31/44

    CPC分类号： C07D401/04 ,  C07D211/90 ,  C07D401/14

    摘要： The present invention provides 1,4-dihydropyridine derivatives of the formula in which ##STR1## R represents hydrogen, alkyl, alkenyl, alkoxyalkyl, aryl or aralkyl, the alkyl and aryl groups being optionally substituted,A represents a straight-chain or branched alkylene radical,R.sup.1 represents (a) an optionally substituted alkylthio group or (b) a group of the formula O--CO-alkyl, O--CO-aryl or O--CO-aralkyl, the alkyl and aryl groups being optionally substituted or (c) a phthalimido radical which is optionally substituted in the benzene ring, Y and Z are identical or different and each represents a group of the formula COOR.sup.2 or COR.sup.2,whereinR.sup.2 represents alkyl, alkenyl, alkinyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl or aralkyl, the alkyl and aryl radicals being optionally substituted, orY and Z are identical or different and each represents a cyano radical or a radical of the formula S(O).sub.n --R.sup.3,whereinR.sup.3 represents alkyl, alkenyl, alkoxyalkyl, aminoalkyl, alkylaminoalkyl, aryl or aralkyl, the alkyl and aryl radicals mentioned being optionally substituted, and n represents 0, 1 or 2,R.sup.4 represents hydrogen or alkyl, the alkyl radical being optionally substituted or interrupted by oxygen, or represents the radical A--R.sup.1,whereinA and R.sup.1 have the abovementioned meaning, and X represents an aryl radical, which optionally contains one to three identical or different substituents selected from phenyl, alkyl, alkenyl, alkinyl, alkoxy, alkinoxy, acyloxy, halogen, trifluoromethyl, trifluoromethoxy, hydroxyl, nitro, cyano, azido, amino, alkylamino, acylamino, carbalkoxy, carboxamido, sulphonamide and S(O).sub.n -alkyl (n=0 to 2), or represents a quinolyl, pyridyl, pyrimidyl, thienyl, furyl or pyrryl radical which is optionally substituted by alkyl, alkylamino, nitro or halogen, or represents an optionally substituted aralkyl, cycloalkyl, cycloalkenyl or styryl radical, and acid addition salts thereof.Also included in the invention are methods for the preparation of the 1,4-dihydropyridine derivatives of the invention, compositions containing said derivatives and methods for their use.