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公开(公告)号:US11771763B2
公开(公告)日:2023-10-03
申请号:US16455077
申请日:2019-06-27
发明人: Alan Horsager , Kenneth Greenberg , Benjamin C. Matteo , Edward S. Boyden , Douglas G. Ririe , James C. Eisenach , Christian Wentz
IPC分类号: A61N5/06 , A61K48/00 , A61K49/00 , A61K41/00 , C07K14/195 , C07K14/37 , A61K31/7088 , C07K14/215
CPC分类号: A61K41/00 , A61K31/7088 , A61N5/062 , C07K14/195 , C07K14/215 , C07K14/37 , C07K2319/60 , C12N2750/14143 , C12N2810/6027
摘要: The present invention provides compositions and methods for the selective silencing of neurons in pain pathway by using a combination of inhibitory light-sensitive protein gene transfer and wavelength specific illumination.
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公开(公告)号:US20150225741A1
公开(公告)日:2015-08-13
申请号:US14298553
申请日:2014-06-06
CPC分类号: A61K48/0058 , A61K45/06 , A61K48/005 , C07K14/70571 , C07K14/723 , C12N15/86 , C12N2710/10043 , C12N2799/025 , C12N2830/008
摘要: Provided herein are compositions and methods for gene and etiology-nonspecific and circuit-specific treatment of diseases, utilizing vectors for delivery of light-sensitive proteins to diseased and normal cells and tissues of interest.
摘要翻译: 本文提供了用于疾病的基因和病因学非特异性和电路特异性治疗的组合物和方法,利用用于将感光蛋白递送至感兴趣的病原体和正常细胞和组织的载体。
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公开(公告)号:US20240269286A1
公开(公告)日:2024-08-15
申请号:US18454275
申请日:2023-08-23
发明人: Alan Horsager , Kenneth Greenberg , Benjamin C. Matteo , Edward S. Boyden , Douglas G. Ririe , James C. Eisenach , Christian Wentz
IPC分类号: A61K41/00 , A61K31/7088 , A61N5/06 , C07K14/195 , C07K14/215 , C07K14/37
CPC分类号: A61K41/00 , A61K31/7088 , A61N5/062 , C07K14/195 , C07K14/215 , C07K14/37 , C07K2319/60 , C12N2750/14143 , C12N2810/6027
摘要: Provided are compositions and methods for the selective silencing of neurons in pain pathway by using a combination of inhibitory light-sensitive protein gene transfer and wavelength specific illumination.
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公开(公告)号:US20210128750A1
公开(公告)日:2021-05-06
申请号:US16823905
申请日:2020-03-19
发明人: Alan Horsager , Andrew Smith , Benjamin C. Matteo
摘要: Provided herein are compositions and methods for the design of synthetic regulatory sequences and for subsequent modulation of neural pathways.
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公开(公告)号:US12097268B2
公开(公告)日:2024-09-24
申请号:US16823905
申请日:2020-03-19
发明人: Alan Horsager , Andrew Smith , Benjamin C. Matteo
CPC分类号: A61K48/0058 , C07K14/4702 , C12N2750/14043 , C12N2830/007
摘要: Provided herein are compositions and methods for the design of synthetic regulatory sequences and for subsequent modulation of neural pathways.
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公开(公告)号:US20210069329A1
公开(公告)日:2021-03-11
申请号:US16455077
申请日:2019-06-27
发明人: Alan Horsager , Kenneth Greenberg , Benjamin C. Matteo , Edward S. Boyden , Douglas G. Ririe , James C. Eisenach , Christian Wentz
IPC分类号: A61K41/00 , C07K14/195 , C07K14/37 , A61K31/7088 , C07K14/215 , A61N5/06
摘要: The present invention provides compositions and methods for the selective silencing of neurons in pain pathway by using a combination of inhibitory light-sensitive protein gene transfer and wavelength specific illumination.
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