公开(公告)号：US20150291624A1

公开(公告)日：2015-10-15

申请号：US14415712

申请日：2013-07-16

Applicant: ENVOY THERAPEUTICS, INC.

Inventor： Stephen Hitchcock ,  Holdger MONENSCHEIN ,  Holly REICHARD ,  Hulkai SUN ,  Shota KIKUCHI ,  Todd MACKLIN ,  Maria HOPKINS

IPC: C07D519/00 ,  C07D498/08 ,  C07D221/22

CPC classification number: C07D498/08 ,  A61K31/19 ,  A61K31/5386 ,  C07C53/18 ,  C07C53/40 ,  C07D221/22 ,  C07D451/12 ,  C07D453/02 ,  C07D471/04 ,  C07D471/08 ,  C07D519/00

Abstract: The present invention provides compounds of the formula: that are 5HT3 receptor antagonists and are therefore useful for the treatment of diseases treatable by inhibition of 5HT3 receptor such as emesis, pain, drug addiction, neurodegenerative and psychiatric disorders, and GI disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Abstract translation: 本发明提供下式的化合物：其为5HT3受体拮抗剂，因此可用于治疗通过抑制5HT3受体如呕吐，疼痛，药物成瘾，神经变性和精神病症以及胃肠疾病而可治疗的疾病。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。