公开(公告)号：US09487526B2

公开(公告)日：2016-11-08

申请号：US14421516

申请日：2013-08-13

Applicant: ENVOY THERAPEUTICS, INC.

Inventor： Stephen Hitchcock ,  Holger Monenschein ,  Holly Reichard ,  Huikai Sun ,  Shota Kikuchi ,  Todd Macklin ,  Maria Hopkins

IPC: C07D487/04 ,  C07D241/44 ,  C07D405/12 ,  C07D471/04

CPC classification number: A61K31/5377 ,  A61K31/197 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/5025 ,  A61K45/06 ,  C07D241/44 ,  C07D405/12 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides compounds of Formula (I): that are GPR6 modulators and are therefore useful for the treatment of diseases treatable by modulation of GPR6, in particular treating Parkinson disease, levodopa induced dyskinesias, Huntington's disease, other dyskinesias, akinesias, and motor disorders involving dysfunction of the striatum, schizophrenia and drug addiction. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Abstract translation: 这是GPR6调节剂，因此可用于治疗通过调节GPR6可治疗的疾病，特别是治疗帕金森病，左旋多巴诱导的运动障碍，亨廷顿病，其他运动障碍，运动障碍和涉及纹状体功能障碍的运动障碍，精神分裂症和药物成瘾 。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。

公开(公告)号：US20150232469A1

公开(公告)日：2015-08-20

申请号：US14421516

申请日：2013-08-13

Applicant: ENVOY THERAPEUTICS, INC.

Inventor： Stephen Hitchcock ,  Holger Monenschein ,  Holly Reichard ,  Huikai Sun ,  Shota Kikuchi ,  Todd Macklin ,  Maria Hopkins

IPC: C07D487/04 ,  C07D405/12 ,  C07D471/04 ,  C07D241/44

CPC classification number: A61K31/5377 ,  A61K31/197 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/5025 ,  A61K45/06 ,  C07D241/44 ,  C07D405/12 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides compounds of Formula (I): that are GPR6 modulators and are therefore useful for the treatment of diseases treatable by modulation of GPR6, in particular treating Parkinson disease, levodopa induced dyskinesias, Huntington's disease, other dyskinesias, akinesias, and motor disorders involving dysfunction of the striatum, schizophrenia and drug addiction. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Abstract translation: 本发明提供式（I）化合物：其是GPR6调节剂，因此可用于治疗通过调节GPR6可治疗的疾病，特别是治疗帕金森病，左旋多巴诱导的运动障碍，亨廷顿舞蹈病，其他运动障碍，运动障碍和运动 涉及纹状体功能障碍，精神分裂症和药物成瘾的疾病。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。

公开(公告)号：US20150291624A1

公开(公告)日：2015-10-15

申请号：US14415712

申请日：2013-07-16

Applicant: ENVOY THERAPEUTICS, INC.

Inventor： Stephen Hitchcock ,  Holdger MONENSCHEIN ,  Holly REICHARD ,  Hulkai SUN ,  Shota KIKUCHI ,  Todd MACKLIN ,  Maria HOPKINS

IPC: C07D519/00 ,  C07D498/08 ,  C07D221/22

CPC classification number: C07D498/08 ,  A61K31/19 ,  A61K31/5386 ,  C07C53/18 ,  C07C53/40 ,  C07D221/22 ,  C07D451/12 ,  C07D453/02 ,  C07D471/04 ,  C07D471/08 ,  C07D519/00

Abstract: The present invention provides compounds of the formula: that are 5HT3 receptor antagonists and are therefore useful for the treatment of diseases treatable by inhibition of 5HT3 receptor such as emesis, pain, drug addiction, neurodegenerative and psychiatric disorders, and GI disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Abstract translation: 本发明提供下式的化合物：其为5HT3受体拮抗剂，因此可用于治疗通过抑制5HT3受体如呕吐，疼痛，药物成瘾，神经变性和精神病症以及胃肠疾病而可治疗的疾病。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。

公开(公告)号：US09012447B2

公开(公告)日：2015-04-21

申请号：US13943634

申请日：2013-07-16

Applicant: Envoy Therapeutics, Inc.

Inventor： Stephen Hitchcock ,  Holger Monenschein ,  Holly Reichard ,  Huikai Sun ,  Shota Kikuchi ,  Todd Macklin ,  Maria Hopkins

IPC: C07D498/04 ,  A61K31/537 ,  C07D498/08 ,  C07D451/12 ,  C07D471/04 ,  C07D519/00

CPC classification number: C07D498/08 ,  A61K31/19 ,  A61K31/5386 ,  C07C53/18 ,  C07C53/40 ,  C07D221/22 ,  C07D451/12 ,  C07D453/02 ,  C07D471/04 ,  C07D471/08 ,  C07D519/00

Abstract: The present invention provides 5-HT3 receptor antagonists of Formula (I): which are useful for the treatment of diseases treatable by inhibition of 5-HT3 receptor such as emesis, pain, drug addiction, neurodegenerative and psychiatric disorders, and GI disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Abstract translation: 本发明提供式（I）的5-HT 3受体拮抗剂：其可用于治疗通过抑制5-HT 3受体如呕吐，疼痛，药物成瘾，神经变性和精神疾病以及GI障碍而可治疗的疾病。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。

公开(公告)号：US20140024644A1

公开(公告)日：2014-01-23

申请号：US13943634

申请日：2013-07-16

Applicant: ENVOY THERAPEUTICS, INC.

Inventor： Stephen Hitchcock ,  Holger Monenschein ,  Holly Reichard ,  Huikai Sun ,  Shota Kikuchi ,  Todd Macklin ,  Maria Hopkins

IPC: C07D498/08

CPC classification number: C07D498/08 ,  A61K31/19 ,  A61K31/5386 ,  C07C53/18 ,  C07C53/40 ,  C07D221/22 ,  C07D451/12 ,  C07D453/02 ,  C07D471/04 ,  C07D471/08 ,  C07D519/00

Abstract: The present invention provides 5-HT3 receptor antagonists of Formula (I): which are useful for the treatment of diseases treatable by inhibition of 5-HT3 receptor such as emesis, pain, drug addiction, neurodegenerative and psychiatric disorders, and GI disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Abstract translation: 本发明提供式（I）的5-HT 3受体拮抗剂：其可用于治疗通过抑制5-HT 3受体如呕吐，疼痛，药物成瘾，神经变性和精神疾病以及GI障碍而可治疗的疾病。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。