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公开(公告)号：US20220073499A1
公开(公告)日：2022-03-10
申请号：US17522176
申请日：2021-11-09
发明人： Joseph D. Panarese , Dexter Davis , Nathaniel Thomas Kenton , Samuel Bartlett , Sean M. Rafferty , Yat Sun Or
IPC分类号： C07D403/14 , C07D401/14 , C07D405/14 , C07D403/12
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable slat thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US11358953B2
公开(公告)日：2022-06-14
申请号：US17522176
申请日：2021-11-09
发明人： Joseph D. Panarese , Dexter Davis , Nathaniel Thomas Kenton , Samuel Bartlett , Sean M. Rafferty , Yat Sun Or
IPC分类号： C07D403/12 , C07D403/14 , C07D405/14 , C07D401/14 , A61P31/14 , C07K5/078 , C07K5/097 , A61K38/00
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable slat thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US11236108B2
公开(公告)日：2022-02-01
申请号：US17022660
申请日：2020-09-16
IPC分类号： C07D495/14 , C07D491/147 , C07D491/153
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US20240140922A1
公开(公告)日：2024-05-02
申请号：US18236560
申请日：2023-08-22
发明人： Samuel Bartlett , Joseph D. Panarese , Sourav Ghorai , Nathaniel Thomas Kenton , Sean Rafferty , Jonathan Thielman , Peilin Xu , Bin Wang , William Cassels , Scott Mitchell , Yat Sun Or
IPC分类号： C07D285/36 , A61P31/20 , C07D337/08 , C07D417/04 , C07D417/08 , C07D417/12 , C07D417/14 , C07D487/04 , C07D513/04 , C07F9/6536
CPC分类号： C07D285/36 , A61P31/20 , C07D337/08 , C07D417/04 , C07D417/08 , C07D417/12 , C07D417/14 , C07D487/04 , C07D513/04 , C07F9/6536
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof:
which inhibit the cellular entry of hepatitis B virus (HBV) and/or hepatitis D virus (HDV) or interfere with the function of the life cycle of HBV and/or HDV and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV and/or HDV infection. The invention also relates to methods of treating an HBV and/or HDV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.-
公开(公告)号：US11802125B2
公开(公告)日：2023-10-31
申请号：US17201308
申请日：2021-03-15
IPC分类号： C07D471/04 , A61K45/06
CPC分类号： C07D471/04 , A61K45/06
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof:
which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.-
公开(公告)号：US20220033383A1
公开(公告)日：2022-02-03
申请号：US17379409
申请日：2021-07-19
发明人： Joseph D. Panarese , Dexter Davis , Nathaniel Thomas Kenton , Samuel Bartlett , Sean M. Rafferty , Yat Sun Or
IPC分类号： C07D403/14 , C07D405/14 , C07D403/12 , C07D401/14
摘要： The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable slat thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20210292320A1
公开(公告)日：2021-09-23
申请号：US17201308
申请日：2021-03-15
IPC分类号： C07D471/04 , A61K45/06
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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公开(公告)号：US20210079014A1
公开(公告)日：2021-03-18
申请号：US17022660
申请日：2020-09-16
IPC分类号： C07D495/14 , C07D491/153 , C07D491/147
摘要： The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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