公开(公告)号：US20210054323A1

公开(公告)日：2021-02-25

申请号：US17017029

申请日：2020-09-10

申请人： EMULATE, Inc.

发明人： Catherine Karalis ,  losif Pediaditakis ,  Athanasia Apostolou

IPC分类号： C12M3/06 ,  B01L3/00 ,  G01N33/50 ,  C12M1/12

摘要： The present invention relates to a combination of cell culture systems and microfluidic fluidic systems for use in providing a human innervated Intestine On-Chip. More specifically, in some embodiments, a microfluidic chip containing intestinal epithelial cells co-cultured with intestinal endothelial cells or intestinal muscle cells, or both, in the presence of induced neural crest cells may find use in providing an innervated Intestine-On-Chip. In some embodiments, an innervated Intestine On-Chip may be used for identifying (testing) therapeutic compounds for use in treating gastrointestinal disorders or diseases.

公开(公告)号：US20200181555A1

公开(公告)日：2020-06-11

申请号：US16712439

申请日：2019-12-12

申请人： EMULATE, INC.

发明人： Christopher David Hinojosa ,  Josiah Sliz ,  losif Pediaditakis ,  Sonalee Barthakur

IPC分类号： C12M1/00 ,  C12M3/06 ,  B01L3/00

摘要： The invention generally relates to a microfluidic platforms or “chips” for testing and conducting experiments on the International Space Station (ISS). More specifically, microfluidic Brain-On-Chip, comprising neuronal and vascular endothelial cells, will be analyzed in both healthy and inflamed states to assess how the circumstances of space travel affect the human brain.