公开(公告)号：US10940307B2

公开(公告)日：2021-03-09

申请号：US16895521

申请日：2020-06-08

Applicant: EMD Millipore Corporation

Inventor： James Vigna ,  Joseph Muldoon ,  John Cieciuch ,  Robert Langlois

IPC: A61M39/18 ,  F16L37/36 ,  F16L37/367 ,  F16L55/07 ,  A61M39/26

Abstract: Fluid transfer device and method that allows for sterile wet connections, allows the connection to be reversed, and allows the connection to be reconnected, while leaving the connectors sterile and reusable under pressure. In certain embodiments, the device includes a first member and a second member, the latter adapted to receive the former in locking engagement upon actuation of the device to create fluid communication between the two in a sterile manner. Each of the members include a door that when opened, allows the first member to be linearly displaced into the second member to allow fluid to be transferred. When fluid transfer is complete, the first member can be retracted from the second member, and the doors closed.

公开(公告)号：US10675454B2

公开(公告)日：2020-06-09

申请号：US15867915

申请日：2018-01-11

Applicant: EMD Millipore Corporation

Inventor： James Vigna ,  Joseph Muldoon ,  John Cieciuch ,  Robert Langlois

IPC: A61M39/18 ,  F16L37/36 ,  F16L37/367 ,  F16L55/07

Abstract: Fluid transfer device and method that allows for sterile wet connections, allows the connection to be reversed, and allows the connection to be reconnected, while leaving the connectors sterile and reusable under pressure. In certain embodiments, the device includes a first member and a second member, the latter adapted to receive the former in locking engagement upon actuation of the device to create fluid communication between the two in a sterile manner. Each of the members include a door that when opened, allows the first member to be linearly displaced into the second member to allow fluid to be transferred. When fluid transfer is complete, the first member can be retracted from the second member, and the doors closed.

公开(公告)号：US20200297990A1

公开(公告)日：2020-09-24

申请号：US16895521

申请日：2020-06-08

Applicant: EMD Millipore Corporation

Inventor： James Vigna ,  Joseph Muldoon ,  John Cieciuch ,  Robert Langlois

IPC: A61M39/18 ,  F16L37/36 ,  F16L37/367 ,  F16L55/07

Abstract: Fluid transfer device and method that allows for sterile wet connections, allows the connection to be reversed, and allows the connection to be reconnected, while leaving the connectors sterile and reusable under pressure. In certain embodiments, the device includes a first member and a second member, the latter adapted to receive the former in locking engagement upon actuation of the device to create fluid communication between the two in a sterile manner. Each of the members include a door that when opened, allows the first member to be linearly displaced into the second member to allow fluid to be transferred. When fluid transfer is complete, the first member can be retracted from the second member, and the doors closed.

公开(公告)号：US20180133453A1

公开(公告)日：2018-05-17

申请号：US15867915

申请日：2018-01-11

Applicant: EMD Millipore Corporation

Inventor： James Vigna ,  Joseph Muldoon ,  John Cieciuch ,  Robert Langlois

IPC: A61M39/18 ,  F16L37/367 ,  F16L55/07 ,  F16L37/36

Abstract: Fluid transfer device and method that allows for sterile wet connections, allows the connection to be reversed, and allows the connection to be reconnected, while leaving the connectors sterile and reusable under pressure. In certain embodiments, the device includes a first member and a second member, the latter adapted to receive the former in locking engagement upon actuation of the device to create fluid communication between the two in a sterile manner. Each of the members include a door that when opened, allows the first member to be linearly displaced into the second member to allow fluid to be transferred. When fluid transfer is complete, the first member can be retracted from the second member, and the doors closed.

公开(公告)号：US09901729B2

公开(公告)日：2018-02-27

申请号：US14773426

申请日：2014-03-26

Applicant: EMD Millipore Corporation

Inventor： James Vigna ,  Joseph Muldoon ,  John Cieciuch ,  Robert Langlois

IPC: F16L37/36 ,  A61M39/18 ,  F16L37/367 ,  F16L55/07

CPC classification number: A61M39/18 ,  F16L37/36 ,  F16L37/367 ,  F16L55/07 ,  F16L2201/44

Abstract: Fluid transfer device and method that allows for sterile wet connections, allows the connection to be reversed, and allows the connection to be reconnected, while leaving the connectors sterile and reusable under pressure. In certain embodiments, the device includes a first member and a second member, the latter adapted to receive the former in locking engagement upon actuation of the device to create fluid communication between the two in a sterile manner. Each of the members include a door that when opened, allows the first member to be linearly displaced into the second member to allow fluid to be transferred. When fluid transfer is complete, the first member can be retracted from the second member, and the doors closed.

公开(公告)号：US20150210973A1

公开(公告)日：2015-07-30

申请号：US14677670

申请日：2015-04-02

Applicant: EMD Millipore Corporation

Inventor： James E. Kelly ,  Joseph William Muldoon ,  Stephen Proulx ,  James Vigna

IPC: C12M3/00 ,  C12M1/00

CPC classification number: C12M23/46 ,  C12M23/20 ,  C12M23/28 ,  C12M23/38 ,  C12M23/48 ,  C12M27/00 ,  C12M29/00

Abstract: The present invention is a disposable, presterilized bioreactor formed of molded plastic, having a top and body attached to each other. One or more ports are formed in the top, side and bottom of the housing. The one or more ports that are below the liquid/air interface level may be used as sampling ports, access ports for probes or drains or supply ports for liquids or gases. The bioreactor provides a direct retrofit for the existing glass or steel assembly that utilizes the existing support structures and controls. The molded design overcomes issues of discontinuity, dead spots and the like due to its fixed dimensions that are built in by the molding process. Reproducible probe and other equipment locations are guaranteed through the use of the molded port features.

Abstract translation: 本发明是由模制塑料形成的一次性预灭菌生物反应器，其具有彼此连接的顶部和主体。 一个或多个端口形成在壳体的顶部，侧面和底部。 低于液体/空气界面水平的一个或多个端口可用作采样端口，用于探针或排水口的接口或用于液体或气体的供应端口。 生物反应器为现有的玻璃或钢组件提供直接改造，利用现有的支撑结构和控制。 成型设计由于其通过模制工艺内置的固定尺寸克服了不连续性，死点等问题。 通过使用模制端口特性，可以保证可重现的探头和其他设备位置。