公开(公告)号：US20230257402A1

公开(公告)日：2023-08-17

申请号：US18031243

申请日：2021-11-01

申请人： EAST CHINA NORMAL UNIVERSITY

发明人： Jian ZHOU ,  BoShuai MU ,  JinSheng YU

IPC分类号： C07F7/18 ,  C07F7/08 ,  C07F7/12 ,  C07D453/04 ,  C07C33/18 ,  C07D215/12

CPC分类号： C07F7/1804 ,  C07F7/081 ,  C07F7/12 ,  C07D453/04 ,  C07F7/0834 ,  C07C33/18 ,  C07D215/12

摘要： Disclosed in the present invention are a functionalized fluoroalkyl silane compound and a synthetic method therefor. The method comprises: dissolving a halosilane and a fluoroalkyl source in an organic solvent; and synthesizing functionalized fluoroalkyl silane under the effect of an alkali or a tertiary phosphine compound. The functionalized fluoroalkyl silane can not only be used for constructing a series of high added-value compounds such as fluoroalkyl substituted alcohols, ketones and amines that can be constructed by conventional TMSRf, but also can transfer, by means of appropriate conversion, a functional group on a silicon protecting group to the obtained addition product in an addition reaction, for synthesizing some fluorine-containing compounds that cannot be synthesized by using a conventional TMSRf reagent, thereby greatly improving the synthesis efficiency and the atom economy of reactions. Also disclosed in the present invention are more excellent reaction efficiency and enantioselectivity, compared with conventional TMSCF3, exhibited by trifluoromethyl chloromethylsilane in synthesis of a 2-trifluoromethylquinoline compound and in an asymmetric trifluoromethylation reaction with α,β-unsaturated ketones.