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公开(公告)号：US20200346018A1
公开(公告)日：2020-11-05
申请号：US16931916
申请日：2020-07-17
申请人： Duke University
IPC分类号： A61N1/36
摘要： Systems and methods for stimulation of neurological tissue and generation stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. The features of the stimulation trains may be selected and arranged algorithmically to by clinical trial. These stimulation trains are generated to target a specific neurological disorder, by arranging sets of features which reduce symptoms of that neurological disorder into a pattern which is effective at reducing those symptoms while maintaining or reducing power consumption versus regular stimulation signals. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide increased efficacy and/or a lower than average frequency.
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公开(公告)号：US10716943B2
公开(公告)日：2020-07-21
申请号：US15896793
申请日：2018-02-14
申请人： Duke University
摘要： Systems and methods for stimulation of neurological tissue and generation stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. The features of the stimulation trains may be selected and arranged algorithmically to by clinical trial. These stimulation trains are generated to target a specific neurological disorder, by arranging sets of features which reduce symptoms of that neurological disorder into a pattern which is effective at reducing those symptoms while maintaining or reducing power consumption versus regular stimulation signals. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide increased efficacy and/or a lower than average frequency.
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公开(公告)号：US20230028428A1
公开(公告)日：2023-01-26
申请号：US17954552
申请日：2022-09-28
申请人： Duke University
IPC分类号： A61N1/36
摘要： Systems and methods for stimulation of neurological tissue and generation stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. The features of the stimulation trains may be selected and arranged algorithmically to by clinical trial. These stimulation trains are generated to target a specific neurological disorder, by arranging sets of features which reduce symptoms of that neurological disorder into a pattern which is effective at reducing those symptoms while maintaining or reducing power consumption versus regular stimulation signals. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide increased efficacy and/or a lower than average frequency.
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公开(公告)号：US20180170130A1
公开(公告)日：2018-06-21
申请号：US15896793
申请日：2018-02-14
申请人： Duke University
摘要： Systems and methods for stimulation of neurological tissue and generation stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. The features of the stimulation trains may be selected and arranged algorithmically to by clinical trial. These stimulation trains are generated to target a specific neurological disorder, by arranging sets of features which reduce symptoms of that neurological disorder into a pattern which is effective at reducing those symptoms while maintaining or reducing power consumption versus regular stimulation signals. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide increased efficacy and/or a lower than average frequency.
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公开(公告)号：US11458318B2
公开(公告)日：2022-10-04
申请号：US16931916
申请日：2020-07-17
申请人： Duke University
摘要： Systems and methods for stimulation of neurological tissue and generation stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. The features of the stimulation trains may be selected and arranged algorithmically to by clinical trial. These stimulation trains are generated to target a specific neurological disorder, by arranging sets of features which reduce symptoms of that neurological disorder into a pattern which is effective at reducing those symptoms while maintaining or reducing power consumption versus regular stimulation signals. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide increased efficacy and/or a lower than average frequency.
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6.发明申请NON-REGULAR ELECTRICAL STIMULATION PATTERNS FOR TREATING NEUROLOGICAL DISORDERS 有权用于治疗神经疾病的非正常电刺激模式公开(公告)号：US20130218239A1
公开(公告)日：2013-08-22
申请号：US13649912
申请日：2012-10-11
申请人： DUKE UNIVERSITY
IPC分类号： A61N1/36
CPC分类号： B60D1/065 , A61N1/0534 , A61N1/36067 , A61N1/36082 , A61N1/36178 , A61N1/36189 , A61N1/36196
摘要： Systems and methods for stimulation of neurological tissue and generation stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. The features of the stimulation trains may be selected and arranged algorithmically to by clinical trial. These stimulation trains are generated to target a specific neurological disorder, by arranging sets of features which reduce symptoms of that neurological disorder into a pattern which is effective at reducing those symptoms while maintaining or reducing power consumption versus regular stimulation signals. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide increased efficacy and/or a lower than average frequency.
摘要翻译： 用于刺激神经组织和生成刺激训练的系统和方法，其中刺激的时间模式（电脉冲间隔（脉冲间隔）随时间变化）变化。 可以通过临床试验来选择和布置刺激训练的特征。 产生这些刺激训练是为了靶向特定的神经系统疾病，通过将能够将神经系统疾病的症状减少到有助于减少这些症状同时维持或降低功率消耗与常规刺激信号的模式的特征集合。 与具有规则（即，恒定）脉冲间隔的常规连续高速脉冲串相比，体现本发明特征的非规则（即不是恒定的）脉冲模式或火车提供增加的功效和/或低于 平均频率
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