知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

22 条记录 (耗时 0.018 秒)

    Method to design temporal patterns of nervous system stimulation
    4.
    发明授权
    Method to design temporal patterns of nervous system stimulation 有权

    公开(公告)号：US11351378B2

    公开(公告)日：2022-06-07

    申请号：US16472466

    申请日：2017-12-21

    申请人： DUKE UNIVERSITY

    发明人： Warren M. Grill ,  David T. Brocker ,  Alexander R. Kent

    IPC分类号： A61N1/36 ,  G16H20/30 ,  G16H50/50 ,  G16B5/20

    摘要： The present invention relates to methods that enable one to design temporal patterns for the optimal stimulation of a nervous system, one or more nerve cells, or nervous tissue. In one embodiment, the present invention relates to methods to design improved stimulation patterns and/or genetic algorithms for the optimal stimulation of a nervous system, one or more nerve cells, or nervous tissue. In one embodiment, the present invention utilizes a model-based design to achieve a more optimal stimulation pattern for use in connection with a nervous system, one or more nerve cells, or nervous tissue (e.g., a human nervous system). In another embodiment, the model-based design of the present invention utilizes a systematic search method to identify parameters (e.g., design variables) that minimize a cost function (e.g., optimize the fitness of a particular design). In one instance, the system and method of the present invention is demonstrated via optimal temporal patterns of electrical stimulation for a nervous system, one or more nerve cells, or nervous tissue.

    Non-regular electrical stimulation patterns designed with a cost function for treating neurological disorders
    6.
    发明授权
    Non-regular electrical stimulation patterns designed with a cost function for treating neurological disorders 有权
    设计具有用于治疗神经障碍的成本函数的非常规电刺激模式

    公开(公告)号：US09572988B2

    公开(公告)日：2017-02-21

    申请号：US15005636

    申请日：2016-01-25

    申请人： Duke University

    发明人： Warren M. Grill ,  David T. Brocker

    IPC分类号： A61N1/08 ,  A61N1/36 ,  A61N1/05

    CPC分类号： A61N1/36178 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36125 ,  A61N1/36128 ,  A61N1/36196

    摘要： Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.

    摘要翻译： 用于刺激神经组织的系统和方法产生具有刺激时间模式的刺激训练，其中电脉冲之间的间隔（脉冲间间隔）随时间变化或变化。 与具有规则（即恒定）脉冲间间隔的常规连续高速脉冲串相比，体现本发明特征的非规则（即，不是恒定的）脉冲模式或火车提供较低的平均频率。

    Non-regular electrical stimulation patterns for treating neurological disorders
    7.
    发明授权
    Non-regular electrical stimulation patterns for treating neurological disorders 有权

    公开(公告)号：US11458318B2

    公开(公告)日：2022-10-04

    申请号：US16931916

    申请日：2020-07-17

    申请人： Duke University

    发明人： Warren M. Grill ,  David T. Brocker ,  Merrill J. Birdno

    IPC分类号： A61N1/36 ,  A61N1/05

    摘要： Systems and methods for stimulation of neurological tissue and generation stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. The features of the stimulation trains may be selected and arranged algorithmically to by clinical trial. These stimulation trains are generated to target a specific neurological disorder, by arranging sets of features which reduce symptoms of that neurological disorder into a pattern which is effective at reducing those symptoms while maintaining or reducing power consumption versus regular stimulation signals. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide increased efficacy and/or a lower than average frequency.

    NON-REGULAR ELECTRICAL STIMULATION PATTERNS DESIGNED WITH A COST FUNCTION FOR TREATING NEUROLOGICAL DISORDERS
    9.
    发明申请
    NON-REGULAR ELECTRICAL STIMULATION PATTERNS DESIGNED WITH A COST FUNCTION FOR TREATING NEUROLOGICAL DISORDERS 有权
    非常规电刺激图案设计用于治疗神经病变的成本函数

    公开(公告)号：US20150174408A1

    公开(公告)日：2015-06-25

    申请号：US14583932

    申请日：2014-12-29

    申请人： Duke University

    发明人： Warren M. Grill, JR. ,  David T. Brocker

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36178 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36125 ,  A61N1/36128 ,  A61N1/36196

    摘要： Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.

    摘要翻译： 用于刺激神经组织的系统和方法产生具有刺激时间模式的刺激训练，其中电脉冲之间的间隔（脉冲间间隔）随时间变化或变化。 与具有规则（即恒定）脉冲间间隔的常规连续高速脉冲串相比，体现本发明特征的非规则（即，不是恒定的）脉冲模式或火车提供较低的平均频率。

    DEVICES, SYSTEMS AND METHODS FOR DEEP BRAIN STIMULATION PARAMETERS
    10.
    发明申请
    DEVICES, SYSTEMS AND METHODS FOR DEEP BRAIN STIMULATION PARAMETERS 审中-公开
    用于深层脑刺激参数的装置，系统和方法

    公开(公告)号：US20140350634A1

    公开(公告)日：2014-11-27

    申请号：US14282496

    申请日：2014-05-20

    申请人： Duke University

    发明人： Warren M. Grill ,  David T. Brocker ,  Alexander R. Kent

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36139 ,  A61B5/04001 ,  A61B5/4064 ,  A61B5/4082 ,  A61B5/4836 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36082 ,  G06K9/00536 ,  G16H50/50

    摘要： Devices, systems and methods for increasing the efficacy and/or efficiency of deep brain stimulation (DBS) using parameters of stimulation that are custom tailored to a unique set of one or more symptoms and/or to a specific patient is shown and described herein. Also disclosed are devices, systems and methods for recording pertinent neural activity during non-regular patterns of stimulation and processing techniques for these recorded signals and stimulation parameter optimization based on these neural recordings may be used to tune computational models of the stimulation patterns to reproduce the observed neural activity.

    摘要翻译： 本文显示并描述了使用针对独特的一组一个或多个症状和/或特定患者定制的刺激参数来增加深部脑刺激（DBS）的功效和/或效率的装置，系统和方法。 还公开了用于在用于这些记录信号的刺激和处理技术的非规则模式下记录相关神经活动的装置，系统和方法，并且可以使用基于这些神经记录的刺激参数优化来调整刺激模式的计算模型以再现 观察神经活动。