公开(公告)号：US11867669B2

公开(公告)日：2024-01-09

申请号：US17715849

申请日：2022-04-07

Applicant: DIONEX SOFTRON GMBH

Inventor： Thomas Wachinger

IPC: G01N30/20 ,  G01N30/24

CPC classification number: G01N30/20 ,  G01N30/24 ,  G01N2030/201 ,  G01N2030/202

Abstract: A sampler for liquid chromatography is described. The sampler includes an injection valve and a sample loop. The injection valve includes one waste port, two sample loop ports, and two high-pressure ports. The sample loop port includes a first loop part and a second loop part. The injection valve can be configured to have LOAD position and INJECT position. The injection valve can also be configured to have one or more additional positions such as a FULL PURGE position, a PUMP PURGE position, and a NEGATIVE PRESSURE position.

公开(公告)号：US20230173480A1

公开(公告)日：2023-06-08

申请号：US17933030

申请日：2022-09-16

Applicant: Dionex Softron GmbH ,  Thermo Fisher (Shanghai) Instrument Co., Ltd.

Inventor： Thomas Wachinger ,  Zhicheng Zhang ,  Hongfang Wang ,  Yongqiang Li

IPC: B01L3/00

CPC classification number: B01L3/502 ,  B01L2400/0475 ,  B01L2400/0622 ,  B01L2400/086

Abstract: A fluidic system for fraction collection comprises a switching valve having a plurality of ports for connecting first and second ports in different configurations. An inlet line is directly connected to the first port, and a collection device is directly connected to the second port. In a collection configuration, the first port and the second port are connected. The ports further comprise third and fourth ports, and the fluidic system further comprises a buffer section directly connected to the third and fourth ports. The fluidic system further comprises a first collection reservoir and is configured to position the collection device to expel a fluid into the first collection reservoir. In a buffer configuration, fluid flows through the inlet line, the first port, the third port, the buffer section, the fourth port, the second port, and the collection device.

公开(公告)号：US20220026399A1

公开(公告)日：2022-01-27

申请号：US17481203

申请日：2021-09-21

Applicant: DIONEX SOFTRON GMBH

Inventor： Thomas Wachinger

IPC: G01N30/20

Abstract: A sample pre-compression valve for liquid chromatography applications is described. The valve enables a sample pre-compression while the solvent pump continues to conduct solvent to the chromatography column. Furthermore, the sample pre-compression valve includes an INJECT position, a LOAD position and a PUMP PURGE position, in which all connecting grooves of the valve are flushed with liquid. A use of the sample pre-compression valve is described as part of a sampler for liquid chromatography applications.

公开(公告)号：US10969369B2

公开(公告)日：2021-04-06

申请号：US15337793

申请日：2016-10-28

Applicant: DIONEX SOFTRON GMBH

Inventor： Thomas Wachinger ,  Daniel Buerger

IPC: G01N30/60 ,  F16L19/02

Abstract: A plug for connecting capillaries includes at least one capillary tube, at least one sealing, and at least one pressure piece. The capillary tube includes a first inner diameter and an open end section. The sealing includes a second inner diameter, a first end section and a shape adapted to seal the open end section of the capillary tube when connected. The pressure piece is adapted to exert at least axial pressure and/or force to at least a part of the sealing. The pressure piece is also adapted to host the first end section of the sealing in abutment with the open end section of the capillary tube so that the capillary tube and the sealing are aligned.

公开(公告)号：US10005006B2

公开(公告)日：2018-06-26

申请号：US14661793

申请日：2015-03-18

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann Hochgraeber ,  Thomas Wachinger

IPC: G01N30/34 ,  B01D15/16 ,  B01D15/14

CPC classification number: B01D15/166 ,  G01N30/34

Abstract: The invention relates to a method for setting a gradient delay volume GDV of a liquid chromatography system for a chromatography run in liquid chromatography, in particular a high-performance liquid chromatography system, in which a desired value GDVtarget of a gradient delay volume of the liquid chromatography system is ascertained or predefined and, if the value GDVtarget deviates from a specific fixed value GDVactual of a liquid chromatography system, this value GDVtarget is set in a range 0≤ΔGDV=GDVtarget−GDVactual≤Vmax of a volume of a volume adjustment device 5. Furthermore, the invention relates to an automatic sampler for carrying out such a method.

公开(公告)号：US09964527B2

公开(公告)日：2018-05-08

申请号：US15190570

申请日：2016-06-23

Applicant: DIONEX SOFTRON GMBH

Inventor： Thomas Wachinger

IPC: G01N30/20 ,  G01N30/02

CPC classification number: G01N30/20 ,  G01N30/22 ,  G01N30/32 ,  G01N2030/027 ,  G01N2030/207

Abstract: A sample pre-compression valve for liquid chromatography applications is described. The valve enables a sample pre-compression while the solvent pump continues to conduct solvent to the chromatography column. Furthermore, the sample pre-compression valve includes an INJECT position, a LOAD position and a PUMP PURGE position, in which all connecting grooves of the valve are flushed with liquid. A use of the sample pre-compression valve is described as part of a sampler for liquid chromatography applications.

公开(公告)号：US11953472B2

公开(公告)日：2024-04-09

申请号：US17667139

申请日：2022-02-08

Applicant: DIONEX SOFTRON GMBH

Inventor： Thomas Wachinger ,  Christoph Hollnagel

IPC: G01N30/20 ,  B01D15/22 ,  G01N30/02 ,  G01N30/08 ,  G01N30/24 ,  G01N30/46 ,  G01N30/60

CPC classification number: G01N30/20 ,  B01D15/22 ,  G01N30/60 ,  G01N2030/027 ,  G01N2030/085 ,  G01N2030/207 ,  G01N30/24 ,  G01N30/468

Abstract: A system for component interconnection for use in liquid chromatography includes a first switching valve and a second switching valve. A first connecting line fluidly connects the first switching valve to the second switching valve. A second connecting line fluidly connects the first switching valve to the second switching valve. A metering device is located in the first connecting line.

公开(公告)号：US11543391B2

公开(公告)日：2023-01-03

申请号：US17481203

申请日：2021-09-21

Applicant: DIONEX SOFTRON GMBH

Inventor： Thomas Wachinger

IPC: G01N30/20 ,  G01N30/22 ,  G01N30/32 ,  G01N30/02

Abstract: A sample pre-compression valve for liquid chromatography applications is described. The valve enables a sample pre-compression while the solvent pump continues to conduct solvent to the chromatography column. Furthermore, the sample pre-compression valve includes an INJECT position, a LOAD position and a PUMP PURGE position, in which all connecting grooves of the valve are flushed with liquid. A use of the sample pre-compression valve is described as part of a sampler for liquid chromatography applications.

公开(公告)号：US11307178B2

公开(公告)日：2022-04-19

申请号：US16664683

申请日：2019-10-25

Applicant: DIONEX SOFTRON GMBH

Inventor： Thomas Wachinger

IPC: G01N30/20 ,  G01N30/24

Abstract: A sampler for liquid chromatography is described. The sampler includes an injection valve and a sample loop. The injection valve includes one waste port, two sample loop ports, and two high-pressure ports. The sample loop port includes a first loop part and a second loop part. The injection valve can be configured to have LOAD position and INJECT position. The injection valve can also be configured to have one or more additional positions such as a FULL PURGE position, a PUMP PURGE position, and a NEGATIVE PRESSURE position.

公开(公告)号：US10816515B2

公开(公告)日：2020-10-27

申请号：US15809190

申请日：2017-11-10

Applicant: DIONEX SOFTRON GMBH

Inventor： Christoph Hollnagel ,  Hermann Hochgraeber ,  Thomas Wachinger

IPC: G01N30/20 ,  G01N30/14 ,  G01N30/36

Abstract: A method of introducing a sample into a separation column includes introducing the sample into a trap column, isolating the trap column from ambient atmosphere and pressurizing the trap column to a first pressure while the trap column is isolated from ambient atmosphere, providing a fluid connection between the trap column and the separation column after pressurizing the trap column to the first pressure, supplying the sample from the trap column to the separation column.