公开(公告)号：US5011964A

公开(公告)日：1991-04-30

申请号：US505695

申请日：1990-04-06

Applicant: Dennis C. Mynarcik ,  Owen W. Griffith ,  Gordon F. Fairclough, Jr.

Inventor： Dennis C. Mynarcik ,  Owen W. Griffith ,  Gordon F. Fairclough, Jr.

IPC: C07F9/10

CPC classification number: C07F9/10

Abstract: Novel diacylglycerophosphoric acid esters include a hydrophobic diacyl glycerol portion to provide water insolubility and a head group which forms a chromophore or a chromophore precursor when the head group is enzymatically released and are chromogenic substrates useful to assay for enzymes catalyzing the cleavage of phosphate ester or phosphoanhydride bonds adjacent or opposite to the phosphatidic acid region of a phospholipid molecule.

Abstract translation: 新型二酰基甘油磷酸酯包括提供水不溶性的疏水性二酰基甘油部分和当头基酶被酶释放时形成发色团或发色团前体的头基，并且是用于测定催化磷酸酯或磷酸酐裂解的酶的显色底物 与磷脂分子的磷脂酸区域相邻或相对的键。

公开(公告)号：US20240130949A1

公开(公告)日：2024-04-25

申请号：US18545611

申请日：2023-12-19

Applicant: Dennis C. Mynarcik

Inventor： Dennis C. Mynarcik

IPC: A61K8/66 ,  A61Q11/00 ,  C12N9/22 ,  C12N9/38 ,  C12N9/76

CPC classification number: A61K8/66 ,  A61Q11/00 ,  C12N9/22 ,  C12N9/2471 ,  C12N9/6427 ,  C12Y302/01023 ,  C12Y304/21001 ,  C12Y304/21004 ,  C12Y304/21064

Abstract: Disclosed are compositions and formulations comprising enzymes or other biocatalyst that cleave surface-accessible DNA polymers and/or glycoprotein carbohydrate chains at galactose residues in dental calculus, and optionally further include one or more proteolytic enzymes, thereby destroying the structural integrity of the calculus, and allowing it to be readily removed without requiring special treatment by a trained dental professional. Also disclosed are methods for removing dental calculus using the disclosed compositions and formulations.

公开(公告)号：US20220062146A1

公开(公告)日：2022-03-03

申请号：US17415359

申请日：2019-12-17

Applicant: Dennis C. Mynarcik

Inventor： Dennis C. Mynarcik

IPC: A61K8/66 ,  C12N9/22 ,  C12N9/38 ,  C12N9/76 ,  A61Q11/00

Abstract: Disclosed are compositions and formulations comprising enzymes or other biocatalyst that cleave surface-accessible DNA polymers and/or glycoprotein carbohydrate chains at galactose residues in dental calculus, and optionally further include one or more proteolytic enzymes, thereby destroying the structural integrity of the calculus, and allowing it to be readily removed without requiring special treatment by a trained dental professional. Also disclosed are methods for removing dental calculus using the disclosed compositions and formulations.