公开(公告)号：US5253646A

公开(公告)日：1993-10-19

申请号：US853183

申请日：1992-03-18

Applicant: David T. Delpy ,  Mark Cope

Inventor： David T. Delpy ,  Mark Cope

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/1464 ,  A61B10/00 ,  A61B6/00

CPC classification number: A61B5/14553

Abstract: A diagnostic apparatus includes light sources which emit near infrared light rays of different wavelengths. The light rays are introduced into human brain to be subjected to diagnosis and the light rays transmitted through the brain are picked up. There are provided a first detector which detects occurrences of respirations of the subject and outputs a respiration signal, and a second detector which detects occurrences of heartbeats of the subject and outputs a heartbeat signal. The light transmitted through the brain is derived in synchronism with both the respiration signal and the heartbeat signal and first and second modulated light transmission signals are produced which are respectively modulated by the respiration signal and the heartbeat signal. The first and second modulated light transmission signals are separately analyzed to provide variations in concentration of oxygenated media .DELTA.X.sub.02 and disoxygenated media .DELTA.X contained in venous and arterial blood of the brain, respectively. Based thereon, oxygen saturations of both venous and arterial blood flowing in the brain are separately computed and displayed in a monitor screen.

公开(公告)号：US4541901A

公开(公告)日：1985-09-17

申请号：US603718

申请日：1984-04-25

Applicant: Dawood Parker ,  David T. Delpy

Inventor： Dawood Parker ,  David T. Delpy

IPC: G01N27/416 ,  G01N27/49 ,  G01N27/46

CPC classification number: G01N27/404 ,  G01N27/4163

Abstract: The calibration of a polarographic oxygen sensor (20) at zero oxygen concentration is accomplished by providing an oxygen-free liquid environment at the sensor active surface. This is accomplished electrolytically by depleting a thin film of electrolyte (24) of oxygen to zero concentration with an oxygen-reducing cathode (6), and complementary anode (4), connected via a battery (10) and switch (12). The sensor (20) is placed into close proximity with the electrodes (4,6) and the oxygen in the electrolyte (24) reduced while its concentration is measured by the sensor (20). A low steady-state signal for the sensor provides the zero oxygen concentration calibration point.

Abstract translation: 在零氧浓度下的极谱氧传感器（20）的校准是通过在传感器有源表面处提供无氧的液体环境来实现的。 这是通过用氧还原阴极（6）和通过电池（10）和开关（12）连接的补充阳极（4））耗尽氧的电解质（24）的薄膜而电解完成的。 将传感器（20）放置成与电极（4,6）非常接近，并且电解质（24）中的氧气减少，同时其传感器（20）测量其浓度。 传感器的低稳态信号提供零氧浓度校准点。

公开(公告)号：US4274417A

公开(公告)日：1981-06-23

申请号：US76724

申请日：1979-09-18

Applicant: David T. Delpy

Inventor： David T. Delpy

IPC: A61B5/00 ,  A61K39/08 ,  A61M25/00

CPC classification number: A61M25/0068 ,  A61B5/14503 ,  A61B5/14528 ,  A61B5/14542 ,  A61M25/0045 ,  A61M2025/0004 ,  A61M2025/0036 ,  A61M2025/0039 ,  A61M2025/004

Abstract: An instrument for use in the measurement of gases in body fluids comprises a flexible catheter having an inner tube within an outer tube, the tubes being of such diameters that there is a substantially cylindrical passage between the tubes which can be evacuated or flushed with a non-interfering gas. Spacers can be provided in the passage, such as radial webs or a single or double helix filament.

Abstract translation: 用于测量体液中的气体的仪器包括柔性导管，其具有在外管内的内管，所述管具有这样的直径，即在管之间存在基本上圆柱形的通道，其可以被抽空或冲洗， - 干扰气体 可以在通道中设置间隔物，例如径向腹板或单螺旋或双螺旋丝。

公开(公告)号：US4957000A

公开(公告)日：1990-09-18

申请号：US298138

申请日：1989-01-18

Applicant: David T. Delpy ,  Hideo Hiruma ,  Susumu Suzuki

Inventor： David T. Delpy ,  Hideo Hiruma ,  Susumu Suzuki

IPC: G01N23/04 ,  A61B8/00 ,  A61B8/08 ,  A61B8/13 ,  A61B10/00 ,  G01N21/17 ,  G01N29/04

CPC classification number: A61B8/4209 ,  A61B8/08 ,  A61B8/13 ,  A61B8/4227

Abstract: An apparatus for obtaining information on the interior of an object, comprising irradiating elements for applying an electromagnetic wave or ultrasonic wave to an object being measured, detecting elements for detecting the electromagnetic wave or ultrasonic wave passed through and scattered inside the object, a holder for supporting the irradiating elements and the detecting elements in such a manner that the irradiating elements and the detecting elements are slidable and position detecting elements for detecting the position data of the irradiating elements and the detecting means with respect to the holder.

公开(公告)号：US4396017A

公开(公告)日：1983-08-02

申请号：US228678

申请日：1981-01-26

Applicant: David T. Delpy ,  Dawood Parker

Inventor： David T. Delpy ,  Dawood Parker

IPC: A61B5/00

CPC classification number: A61B5/14542 ,  A61B5/1477

Abstract: A transcutaneous gas sensor for application to the body surface of a patient is provided. The sensor includes a sensing electrode having an exposed surface region which, in use, is applied to the body surface of the patient with an electrolyte layer between the electrode and the patient's body. Gas which has diffused through the patient's body from his blood to the body surface results in an electrochemical reaction taking place at the exposed surface region of the electrode. This exposed surface region can consist of an individual surface area, or several such surface areas. In one embodiment, the surface area or areas are arranged and are of a configuration such as to have associated therewith an imaginary envelope of greater area than the total area occupied by the individual surface area or areas; with such an arrangement, the surface area or areas have the same or similar widths. In a second embodiment, the or each exposed surface area(s) of the electrode has a sufficiently small width dimension and is shaped and arranged so that the depletion zone set up in the electrolyte layer when the sensor is in use is confined to a depth not exceeding about 1 mm. The flow of gas from the patient's blood to his body surface can be encouraged by local heating of the area under investigation. Detection of the current flowing through the electrode as a result of the electrochemical reaction in the electrolyte layer provides a measure of the gas partial pressure in the patient's blood.

Abstract translation: 提供了一种应用于患者体表的经皮气体传感器。 所述传感器包括感测电极，所述感测电极具有暴露的表面区域，所述暴露表面区域在使用中被施加到患者的身体表面，其中电极与患者身体之间具有电解质层。 通过患者身体从血液扩散到身体表面的气体导致在电极的暴露表面区域发生电化学反应。 该暴露的表面区域可以由单独的表面积或几个这样的表面积组成。 在一个实施例中，表面积或面积被布置，并且具有如下构造，即具有与单独的表面区域占据的总面积相比更大面积的假想包络线; 通过这种布置，表面积或宽度相同或相似。 在第二实施例中，电极的每个或每个暴露的表面积具有足够小的宽度尺寸，并且其形状和布置使得当传感器使用时在电解质层中设置的耗尽区被限制在深度 不超过约1毫米。 可以通过对被调查地区的局部加热来鼓励从患者血液到身体的气体流。 由于电解质层中的电化学反应，检测流过电极的电流提供了患者血液中气体分压的量度。

公开(公告)号：US5251632A

公开(公告)日：1993-10-12

申请号：US727168

申请日：1991-07-09

Applicant: David T. Delpy

Inventor： David T. Delpy

IPC: A61B5/08 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455

CPC classification number: A61B5/14553

Abstract: A tissue oxygen measuring system enabling the automatic and continuous measurement of diagnosing items including cerebral blood flow, cerebral blood volume, and response of cerebral blood volume in arterial carbon dioxide tension uses an oxygen measuring system based on near infrared spectroscopy, a pulse oximeter, and an arterial carbon dioxide tension measuring unit. A gas blending unit is employed before a ventilator or face mask to control the ventilator so that a rate of a quantity of oxygen and/or a quantity of carbon dioxide to be blended in the air is changed at predetermined intervals. Trigger signals are produced in synchronism with the changes of the gaseous contents of the air, and parameters for computing information regarding the diagnosing items are measured in response to the trigger signals. With the repetitive measurements of the parameters, a signal-to-noise ratio can be improved by averaging the data and erroneous data can easily be identified.

公开(公告)号：US4452672A

公开(公告)日：1984-06-05

申请号：US455615

申请日：1983-01-04

Applicant: Dawood Parker ,  David T. Delpy

Inventor： Dawood Parker ,  David T. Delpy

IPC: A61B5/00 ,  G01N27/48 ,  G01N27/46

CPC classification number: A61B5/14542 ,  A61B5/1477 ,  G01N27/48

Abstract: The determination of the concentration of compounds such as CO.sub.2 having an influence on the pH of a medium during polarography is described. Characteristics of polarograms when obtained in unbuffered electrolytes (the polarogram plateau slope position of the upper knee and half-wave potential thereof) are pH-sensitive. These can be detected electronically and signals processed to provide a measure of such concentrations.In one preferred embodiment (FIG. 2) a miniature pO.sub.2 polarographic sensor has cathode channels (A) and (B) biased respecitvely at -750 mV and -950 mV. The output of channel (A) provides pO.sub.2 as in normal polarography. The output of (B) is divided (6) and further corrected for pO.sub.2 (8,10) to provide pCO.sub.2.The apparatus is especially useful for simultaneous pO.sub.2, pCO.sub.2 monitoring in physiological fluids without the need for a separate pCO.sub.2 sensor.

Abstract translation: 描述了在极谱法中测定对介质的pH具有影响的化合物如CO 2的浓度。 在无缓冲电解质（上限的极谱图平台坡度位置和半波电位）中获得的极谱图的特性是pH敏感的。 这些可以被电子检测和信号处理以提供这样的浓度的量度。 在一个优选实施例（图2）中，微型pO2极谱传感器具有阴极通道（A）和（B）分别在-750mV和-950mV偏置。 通道（A）的输出可提供正常极谱法中的pO2。 （B）的输出被划分为（6）并进一步校正pO2（8,10）以提供pCO2。 该装置对于在生理液体中同时进行pO2，pCO2监测是特别有用的，而不需要单独的pCO2传感器。

公开(公告)号：US4220158A

公开(公告)日：1980-09-02

申请号：US960703

申请日：1978-11-14

Applicant: David T. Delpy ,  Dawood Parker

Inventor： David T. Delpy ,  Dawood Parker

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  B32B5/18 ,  G01N27/40 ,  G01N33/49

CPC classification number: A61B5/145 ,  A61B5/1491 ,  B32B5/18 ,  G01N27/40

Abstract: A transcutaneous probe for causing oxygen and other gases or vapors carried in the bloodstream of a mammal to be extracted from the blood through the skin and passed to a device, such as a mass spectrometer, for analyzing the extracted gas. The probe has a boundary wall intended to be placed in contact with the skin comprising a first layer of gas permeable material and a second layer of perforate or porous gas-impermeable material in intimate contact with the first, the size and distribution of the perforations or pores in the second layer being such that the wall has a substantially uniform extrinsic macropermeability which is significantly lower than the inherent permeability of the first layer alone and such that in use, gas passes into the perforations or pores of the second layer from respective volumes of tissue which do not substantially overlap.

Abstract translation: 用于引起在哺乳动物的血液中携带的氧气和其它气体或蒸气从皮肤中从血液中提取的经皮探针，并将其传送到诸如质谱仪的装置，用于分析提取的气体。 探针具有旨在与皮肤接触的边界壁，包括第一层透气材料和第二层穿孔或多孔气体不可渗透材料，与第一，穿孔的尺寸和分布密切接触，或 第二层中的孔使得壁具有基本均匀的外在大孔渗透性，其显着低于第一层单独的固有渗透性，并且在使用中，气体从相应体积的第二层中渗入第二层的穿孔或孔 组织基本上不重叠。