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1.发明授权公开(公告)号：US07666914B2
公开(公告)日：2010-02-23
申请号：US10709880
申请日：2004-06-03
CPC分类号： A61K9/0014 , A61K45/06 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/24 , Y10S514/816 , Y10S514/817 , Y10S514/818 , Y10S514/886 , Y10S514/887 , Y10S514/93 , Y10S514/936 , Y10S514/946 , Y10S514/947
摘要： Disclosed herein is a preparation for topically delivering and localizing therapeutic agents, comprising: a vasoconstrictor for retarding vascular dispersion of a therapeutic agent; and a penetration enhancer for facilitating penetration of the vasoconstrictor and the therapeutic agent through a patient's skin. Further disclosed is an associated method of topically delivering and localizing therapeutic agents, comprising the steps of: using a vasoconstrictor for retarding vascular dispersion of a therapeutic agent; in combination with using a penetration enhancer for facilitating penetration of the vasoconstrictor and the therapeutic agent through a patient's skin. Also disclosed are various courses of treatment which comprise applying the various disclosed combinations of agents to the patient's skin.
摘要翻译： 本文公开了用于局部递送和定位治疗剂的制剂，其包括：用于延缓治疗剂的血管分散的血管收缩剂; 以及用于促进血管收缩剂和治疗剂通过患者皮肤穿透的渗透增强剂。 还公开了一种局部递送和定位治疗剂的相关方法，包括以下步骤：使用血管收缩剂来延缓治疗剂的血管分散; 与使用渗透促进剂组合以促进血管收缩剂和治疗剂通过患者皮肤的渗透。 还公开了各种治疗方案，其包括将各种所公开的药剂组合应用于患者的皮肤。
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2.发明授权公开(公告)号：US08211887B2
公开(公告)日：2012-07-03
申请号：US11569805
申请日：2005-06-01
IPC分类号： A61K31/54
CPC分类号： A61K9/0014 , A61K45/06 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/24 , Y10S514/816 , Y10S514/817 , Y10S514/818 , Y10S514/886 , Y10S514/887 , Y10S514/93 , Y10S514/936 , Y10S514/946 , Y10S514/947
摘要： Disclosed herein is a preparation for topically delivering and localizing therapeutic agents, comprising: a vasoconstrictor for retarding vascular dispersion of a therapeutic agent; and a penetration enhancer for facilitating penetration of the vasoconstrictor and the therapeutic agent through a patient's skin. Further disclosed is an associated method of topically delivering and localizing therapeutic agents, comprising the steps of: using a vasoconstrictor for retarding vascular dispersion of a therapeutic agent; in combination with using a penetration enhancer for facilitating penetration of the vasoconstrictor and the therapeutic agent through a patient's skin. Also disclosed are various courses of treatment, which comprise applying the various disclosed combinations of agents to the patient's skin.
摘要翻译： 本文公开了用于局部递送和定位治疗剂的制剂，其包括：用于延缓治疗剂的血管分散的血管收缩剂; 以及用于促进血管收缩剂和治疗剂通过患者皮肤穿透的渗透增强剂。 还公开了一种局部递送和定位治疗剂的相关方法，包括以下步骤：使用血管收缩剂来延缓治疗剂的血管分散; 与使用渗透促进剂组合以促进血管收缩剂和治疗剂通过患者皮肤的渗透。 还公开了各种疗程，其包括将各种公开的药剂组合应用于患者的皮肤。
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3.发明申请公开(公告)号：US20080293703A1
公开(公告)日：2008-11-27
申请号：US11569805
申请日：2005-06-01
IPC分类号： A61K31/5415 , A61P29/00 , A61P31/12 , A61P9/00 , A61P23/02
CPC分类号： A61K9/0014 , A61K45/06 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/24 , Y10S514/816 , Y10S514/817 , Y10S514/818 , Y10S514/886 , Y10S514/887 , Y10S514/93 , Y10S514/936 , Y10S514/946 , Y10S514/947
摘要： Disclosed herein is a preparation for topically delivering and localizing therapeutic agents, comprising: a vasoconstrictor for retarding vascular dispersion of a therapeutic agent; and a penetration enhancer for facilitating penetration of the vasoconstrictor and the therapeutic agent through a patient's skin. Further disclosed is an associated method of topically delivering and localizing therapeutic agents, comprising the steps of: using a vasoconstrictor for retarding vascular dispersion of a therapeutic agent; in combination with using a penetration enhancer for facilitating penetration of the vasoconstrictor and the therapeutic agent through a patient's skin. Also disclosed are various courses of treatment, which comprise applying the various disclosed combinations of agents to the patient's skin.
摘要翻译： 本文公开了用于局部递送和定位治疗剂的制剂，其包括：用于延缓治疗剂的血管分散的血管收缩剂; 以及用于促进血管收缩剂和治疗剂通过患者皮肤穿透的渗透增强剂。 还公开了一种局部递送和定位治疗剂的相关方法，包括以下步骤：使用血管收缩剂来延缓治疗剂的血管分散; 与使用渗透促进剂组合以促进血管收缩剂和治疗剂通过患者皮肤的渗透。 还公开了各种疗程，其包括将各种公开的药剂组合应用于患者的皮肤。
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