-
公开(公告)号：US20050132424A1
公开(公告)日：2005-06-16
申请号：US10969898
申请日：2004-10-21
申请人： David Lowe , Gerhard Koenig , Christopher Cummings
发明人： David Lowe , Gerhard Koenig , Christopher Cummings
IPC分类号： A01K67/033 , C12N15/85
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/0312 , C12N15/8509
摘要： The present invention discloses a transgenic fly that expresses the Dutch mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Dutch peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
摘要翻译： 本发明公开了一种表达人淀粉样蛋白-β前体蛋白（APP）的人Abeta42肽的荷兰突变型的转基因飞蝇，以及表达Tau蛋白和人Abeta42前体蛋白的双重转基因蝇， 人淀粉样蛋白-β前体蛋白质（APP）的肽。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。
-
公开(公告)号：US20050108779A1
公开(公告)日：2005-05-19
申请号：US10852974
申请日：2004-05-25
申请人： David Lowe , Gerhard Koenig , Christopher Cummings
发明人： David Lowe , Gerhard Koenig , Christopher Cummings
IPC分类号： A01K67/033
CPC分类号： A01K67/0333 , A01K67/0339 , A01K2267/0312
摘要： The present invention discloses a transgenic fly that expresses the Italian mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Italian peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
摘要翻译： 本发明公开了一种表达人淀粉样蛋白-β前体蛋白（APP）的人Abeta42肽的意大利突变体型的转基因飞行物，以及表达Tau蛋白质和人类Abeta42前体蛋白质的双重转基因飞行物， 人淀粉样蛋白-β前体蛋白质（APP）的肽。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。
-
公开(公告)号：US20050132425A1
公开(公告)日：2005-06-16
申请号：US10970189
申请日：2004-10-21
申请人： David Lowe , Gerhard Koenig , Christopher Cummings
发明人： David Lowe , Gerhard Koenig , Christopher Cummings
IPC分类号： A01K67/033
CPC分类号： A01K67/0333 , A01K67/0339 , A01K2267/0312
摘要： The present invention discloses a transgenic fly that expresses the Italian mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Italian peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
-
公开(公告)号：US20050132423A1
公开(公告)日：2005-06-16
申请号：US10969895
申请日：2004-10-21
申请人： David Lowe , Gerhard Koenig , Christopher Cummings
发明人： David Lowe , Gerhard Koenig , Christopher Cummings
IPC分类号： A01K67/033 , C12N15/85
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/0312 , C12N15/8509
摘要： The present invention discloses a transgenic fly that expresses the Flemish mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Flemish peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
摘要翻译： 本发明公开了一种表达人淀粉样蛋白-β前体蛋白（APP）的人Abeta42肽的佛兰芒突变体型的转基因飞行物，以及表达Tau蛋白和人类Abeta42前体蛋白（APP）的双转基因飞行物， 人淀粉样蛋白-β前体蛋白质（APP）的肽。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。
-
公开(公告)号：US20050132421A1
公开(公告)日：2005-06-16
申请号：US10969893
申请日：2004-10-21
申请人： David Lowe , Gerhard Koenig , Christopher Cummings
发明人： David Lowe , Gerhard Koenig , Christopher Cummings
IPC分类号： A01K67/00 , A01K67/033 , C12N15/85 , G01N33/00
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/0312 , C12N15/8509
摘要： The present invention discloses a transgenic fly that expresses the Arctic mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Arctic peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
摘要翻译： 本发明公开了表达人淀粉样蛋白-β前体蛋白（APP）的人Abeta42肽的北极突变体版本的转基因飞行物，以及表达Tau蛋白质和人Abeta42二极体的双重转基因飞行物， 人淀粉样蛋白-β前体蛋白质（APP）的肽。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。
-
公开(公告)号：US20050132422A1
公开(公告)日：2005-06-16
申请号：US10969894
申请日：2004-10-21
申请人： David Lowe , Gerhard Koenig , Christopher Cummings
发明人： David Lowe , Gerhard Koenig , Christopher Cummings
IPC分类号： A01K67/00 , A01K67/033 , C12N15/85 , G01N33/00
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/0312 , C12N15/8509
摘要： The present invention discloses a transgenic fly that expresses the Iowa mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Iowa peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
摘要翻译： 本发明公开了表达人淀粉样蛋白-β前体蛋白（APP）的人Aβ42肽的爱荷华突变体版本的转基因飞行物，以及表达Tau蛋白和人Abeta42爱荷华双重转基因飞蝇 人淀粉样蛋白-β前体蛋白质（APP）的肽。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。
-
公开(公告)号：US20060004041A1
公开(公告)日：2006-01-05
申请号：US11120502
申请日：2005-05-03
申请人： Christopher Cummings , David Lowe , William Ripka
发明人： Christopher Cummings , David Lowe , William Ripka
IPC分类号： A61K31/4709 , C07D43/02 , C07D41/02
CPC分类号： C07D217/02 , A61K31/47 , C07D217/06 , C07D217/08 , C07D401/06 , C07D401/10 , C07D401/12 , C07D409/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of small molecule hydroxamic acid compounds capable of inhibiting histone deacetylases (HDACs). The present invention also relates to methods of preparation of hydroxamic acid HDAC inhibitor compounds of the invention, which are N-substituted-1,2,3,4-tetrahydroisoquinoline hydroxamic acid derivatives, and their incorporation into pharmaceutical compositions and methods of administration. The present invention also relates to N-substituted-1,2,3,4-tetrahydroisoquinoline hydroxamic acid derivatives, which may be prepared as a hydroxamic acid HDAC inhibitor compound library that can be utilized in screening methods known in the art.
摘要翻译： 本发明涉及能抑制组蛋白脱乙酰酶（HDAC）的一类小分子异羟肟酸化合物。 本发明还涉及本发明的异羟肟酸HDAC抑制剂化合物的制备方法，它们是N-取代-1,2,3,4-四氢异喹啉异羟肟酸衍生物，以及它们掺入药物组合物和给药方法中。 本发明还涉及可以用于本领域已知的筛选方法中的异羟肟酸HDAC抑制剂化合物文库的N-取代-1,2,3,4-四氢异喹啉异羟肟酸衍生物。
-
8.发明申请Method of treating neurological disorders using clotrimazole and derivatives thereof 审中-公开使用克霉唑及其衍生物治疗神经障碍的方法公开(公告)号：US20070037800A1
公开(公告)日：2007-02-15
申请号：US11473479
申请日：2006-06-23
IPC分类号： A61K31/5375 , A61K31/4196 , A61K31/4192 , A61K31/415 , A61K31/41
CPC分类号： A61K31/415 , A61K31/41 , A61K31/4192 , A61K31/4196 , A61K31/5375
摘要： Methods and pharmaceutical compositions are disclosed for treating neurological disorders, such as Huntington's disease or Alzheimer's disease. The methods involve the administration of a triarylmethane compound, such as clotrimazole, or a salt thereof.
摘要翻译： 公开了用于治疗诸如亨廷顿病或阿尔茨海默氏病之类的神经障碍的方法和药物组合物。 所述方法包括施用三芳基甲烷化合物，例如克霉唑或其盐。
-
公开(公告)号：US20080259460A1
公开(公告)日：2008-10-23
申请号：US12080108
申请日：2008-03-31
CPC分类号： G02B27/0994
摘要： A non-uniform light source is combined with a system including an integrating light pipe, a mask placed at the output of the light pipe, and a focusing element placed one focal length beyond the light pipe output at an angle appropriate for directing the light toward the illumination plane of the system. The purpose of the mask is to attenuate areas of the light pipe output that correspond to high irradiance regions at the illumination plane. Accordingly, this combination of optical components produces light with desired irradiance profile, including a substantially uniform irradiance profile, at the illumination plane.
摘要翻译： 不均匀光源与包括集成光管，放置在光管输出端的掩模和聚焦元件的系统组合在一起，该聚焦元件以适于将光导向 系统的照明平面。 掩模的目的是衰减对应于照明平面处的高辐照度区域的光管输出的区域。 因此，这种光学组件的组合在照明平面处产生具有期望的辐照度分布的光，包括基本均匀的辐照度分布。
-
公开(公告)号：US20080076145A1
公开(公告)日：2008-03-27
申请号：US11818413
申请日：2007-06-14
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/0312 , C07K14/4711 , C12N15/8509 , C12N2830/002 , C12N2830/008
摘要： The present invention discloses a transgenic fly that expresses a carboxy terminal fragment of the human amyloid-β precursor protein (APP) and a double transgenic fly that expresses both the fragment of APP and tau protein. The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
摘要翻译： 本发明公开了表达人淀粉样蛋白-β前体蛋白（APP）的羧基末端片段和表达APP和tau蛋白片段的双转基因飞蝇的转基因飞行物。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.026 秒)
