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    Methods and procedures for stabilization and performance optimization of multi-layer sol-gel chemical and biochemical sensors
    1.
    发明授权
    Methods and procedures for stabilization and performance optimization of multi-layer sol-gel chemical and biochemical sensors 有权
    多层溶胶 - 凝胶化学和生物化学传感器的稳定和性能优化的方法和程序

    公开(公告)号：US07393693B2

    公开(公告)日：2008-07-01

    申请号：US10159301

    申请日：2002-05-31

    申请人： David J. Anvar ,  Ganapati R. Mauze ,  Dan-Hui Yang

    发明人： David J. Anvar ,  Ganapati R. Mauze ,  Dan-Hui Yang

    IPC分类号： G01N30/00

    CPC分类号： G01N33/6803 ,  Y10T436/25 ,  Y10T436/2525

    摘要： A sensor and method for making a sensor includes providing a substrate having an adhesion layer with a first functional group operatively associated with a sol-gel composition having a second functional group, and at least one linker material for connecting the first functional group to the second functional group. In another embodiment, a sensor and method for making the sensor includes providing a sol-gel layer operatively associated with a sol-gel precursor solution that includes at least one co-polymer and at least one solvent adapted to resist the deformation of the sol-gel layer by decreasing evaporation, decreasing cross-linking, increasing intermolecular forces, or increasing elasticity.

    摘要翻译： 用于制造传感器的传感器和方法包括提供具有粘附层的基底，其具有与具有第二官能团的溶胶 - 凝胶组合物操作性相关联的第一官能团，以及用于将第一官能团连接到第二官能团的至少一种连接材料 功能组。 在另一个实施方案中，用于制造传感器的传感器和方法包括提供可操作地与溶胶 - 凝胶前体溶液相关联的溶胶 - 凝胶层，所述溶胶 - 凝胶层包括至少一种共聚物和至少一种适于抵抗溶胶 - 凝胶前体溶液变形的溶剂 - 凝胶层通过减少蒸发，减少交联，增加分子间力或增加弹性。

    Trace gas sensor with reduced degradation
    2.
    发明授权
    Trace gas sensor with reduced degradation 有权
    痕量气体传感器降低降解

    公开(公告)号：US07278291B2

    公开(公告)日：2007-10-09

    申请号：US11348925

    申请日：2006-02-06

    申请人： David J. Chazan ,  David J. Anvar ,  Autumn Talbott

    发明人： David J. Chazan ,  David J. Anvar ,  Autumn Talbott

    IPC分类号： G01N7/00 ,  G01N9/00

    CPC分类号： G01N33/497

    摘要： The degradation over time that is commonly seen with analyte-binding proteins when used as sensors for trace amounts of an analyte in a gaseous mixture is reduced by maintaining the sensor in a low-oxygen or oxygen-free environment.

    摘要翻译： 当用作气体混合物中微量分析物的传感器时，通过分析物结合蛋白通常观察到的随时间的降解通过将传感器保持在低氧或无氧环境中来降低。

    Reduction of carbon monoxide interference in gaseous analyte detectors
    6.
    发明授权
    Reduction of carbon monoxide interference in gaseous analyte detectors 有权
    降低气态分析物检测器中的一氧化碳干扰

    公开(公告)号：US07611671B2

    公开(公告)日：2009-11-03

    申请号：US11250958

    申请日：2005-10-14

    申请人： David J. Anvar ,  David J. Chazan ,  Bryan P. Flaherty ,  Bhairavi R. Parikh

    发明人： David J. Anvar ,  David J. Chazan ,  Bryan P. Flaherty ,  Bhairavi R. Parikh

    IPC分类号： G01N33/497

    CPC分类号： G01N21/783 ,  G01N21/76 ,  G01N33/0037 ,  G01N33/0059 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  Y02A50/245 ,  Y10T436/177692 ,  Y10T436/179228

    摘要： Highly sensitive devices for detecting nitric oxide and/or other gaseous analytes in gaseous samples are improved by the incorporation of a carbon monoxide scavenger in the interior of the device or in the device packaging. The release of carbon monoxide within the housing of the device by the plastic used in the construction of the housing or by anything within the device that releases carbon monoxide causes a loss in sensitivity due to competition between the carbon monoxide and the nitric oxide for the binding sites on the device sensor. The scavenger corrects this by either catalyzing the oxidation of carbon monoxide to the less competitive carbon dioxide or immobilizing the carbon monoxide by affinity-type or covalent binding. Analogous effects are achieved for analytes other than nitric oxide but that likewise encounter interference from carbon monoxide in binding to sensors.

    摘要翻译： 通过将一氧化碳清除剂并入装置的内部或在装置包装中，用于检测气态样品中一氧化氮和/或其它气态分析物的高灵敏度装置得到改善。 通过用于建筑外壳中的塑料或释放一氧化碳的装置内的任何物质，在装置的壳体内释放一氧化碳导致由于一氧化碳和一氧化氮之间的竞争导致的结合的灵敏度损失 设备传感器上的站点。 清除剂通过催化一氧化碳氧化成竞争力较低的二氧化碳或通过亲和型或共价结合固定一氧化​​碳来纠正这一点。 对一氧化氮以外的分析物也能达到类似的效果，但同样遇到一氧化碳与传感器结合的干扰。