公开(公告)号：US08063087B2

公开(公告)日：2011-11-22

申请号：US12180162

申请日：2008-07-25

申请人： Ken Chow ,  Todd Heidelbaugh ,  Daniel Gill ,  Michael Garst ,  Larry A. Wheeler ,  Phong X. Nguyen ,  Dario G. Gomez

发明人： Ken Chow ,  Todd Heidelbaugh ,  Daniel Gill ,  Michael Garst ,  Larry A. Wheeler ,  Phong X. Nguyen ,  Dario G. Gomez

IPC分类号： A61K31/4164 ,  C07D233/30

CPC分类号： C07D401/06 ,  C07D233/70 ,  C07D233/84 ,  C07D405/06 ,  C07D409/06 ,  C07D409/08

摘要： Compounds of Formula 1 where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors, and as such have no or only minimal cardiovascular and/or sedatory activity. These compounds of Formula 1 are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2B adrenergic receptors. Compounds of Formula 1 where X is O also have the advantageous property that they have no or only minimal cardiovascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardiovascular and/or sedatory activity.

摘要翻译： 式1的化合物，其中X为S且变量具有本说明书中定义的含义，优先选择α2B和/或α2C肾上腺素能受体，优于α2A肾上腺素能受体，因此没有或只有最小的心血管和/或镇静剂 活动。 式1的这些化合物可用作哺乳动物（包括人）中用于治疗疾病的药物和/或缓解对α2B肾上腺素能受体的激动剂治疗有反应的病症。 其中X为O的式1的化合物也具有它们没有或只有最小的心血管和/或镇静活性的有利特性，并且可用于治疗没有或仅有最小的心血管和/或镇静活性的疼痛和其它状况。

公开(公告)号：US20060129088A1

公开(公告)日：2006-06-15

申请号：US11257671

申请日：2005-10-25

申请人： Daniel Gill ,  Stephen Muscarella ,  Leonid Buchman ,  Patrick Miller ,  Cordell Claude ,  Dennis Heidt

发明人： Daniel Gill ,  Stephen Muscarella ,  Leonid Buchman ,  Patrick Miller ,  Cordell Claude ,  Dennis Heidt

IPC分类号： A61M31/00

CPC分类号： F04B49/06 ,  F04B49/00 ,  F04B2201/0206 ,  F04B2203/0209

摘要： A metering pump system having a human interface device that is selectively mounted to a pump base. In an embodiment of the invention, sensors are provided that monitor characteristics corresponding to the material being pumped, and provide information about those characteristics to a computer which alters pumping parameters based on the characteristics.

摘要翻译： 一种计量泵系统，具有选择性地安装在泵基座上的人机接口装置。 在本发明的一个实施例中，提供了传感器，其监测与被泵送的材料相对应的特性，并且将关于这些特征的信息提供给基于特征改变泵送参数的计算机。

公开(公告)号：US11879422B1

公开(公告)日：2024-01-23

申请号：US17681327

申请日：2022-02-25

申请人： Daniel Gill

发明人： Daniel Gill

IPC分类号： F03B17/00 ,  F03B17/02

CPC分类号： F03B17/025

摘要： Disclosed herein are systems and methods for generating energy from a container configured to be fully submerged in a liquid and containing differing volumes of gas in order to alternatively ascend and descend through the liquid in order to rotate a drum spool connected to the container by a cable hose that unwinds from the drum spool as the container ascends, and winds as the cable descends. The rotational energy of the drum spool may thus be harvested.