公开(公告)号：US20170096388A1

公开(公告)日：2017-04-06

申请号：US15383635

申请日：2016-12-19

申请人： DUQUESNE UNIVERSITY OF THE HOLY GHOST

发明人： SURAVI CHAKRABARTY ,  DARLENE MONLISH ,  PATRICK FLAHERTY ,  JANE E. CAVANAUGH ,  SNEHA POTDAR

IPC分类号： C07C227/10

CPC分类号： C07C227/10 ,  C07C229/58

摘要： The invention generally relates to compounds having structure I: wherein x represents alkyl, aryl or het-aryl, each of y independently represents hydrogen or halogen and z represents hydrogen or alkyl. Further, said compounds are inhibitors of MEK 1, 2 and 5. Furthermore, the invention includes methods of making said compounds, compositions including said compounds and uses for inhibiting MEK 1, 2 and 5.

公开(公告)号：US20140135519A1

公开(公告)日：2014-05-15

申请号：US14081426

申请日：2013-11-15

申请人： DUQUESNE UNIVERSITY OF THE HOLY GHOST

发明人： SURAVI CHAKRABARTY ,  Darlene Monlish ,  Patrick Flaherty ,  Jane E. Cavanaugh ,  Sneha Potdar

IPC分类号： C07C229/64 ,  C07C227/10

CPC分类号： C07C227/10 ,  C07C229/58

摘要： The invention generally relates to compounds having structure I: wherein x represents alkyl, aryl or het-aryl, each of y independently represents hydrogen or halogen and z represents hydrogen or alkyl. Further, said compounds are inhibitors of MEK 1, 2 and 5. Furthermore, the invention includes methods of making said compounds, compositions including said compounds and uses for inhibiting MEK 1, 2 and 5.

摘要翻译： 本发明一般涉及具有结构I的化合物：其中x代表烷基，芳基或苯基 - 芳基，y各自独立地表示氢或卤素，z代表氢或烷基。 此外，所述化合物是MEK 1,2和5的抑制剂。此外，本发明包括制备所述化合物，包含所述化合物的组合物和用于抑制MEK 1,2和5的方法。