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    Substituted naphthyridine and quinoline compounds as MAO inhibitors
    2.
    发明授权
    Substituted naphthyridine and quinoline compounds as MAO inhibitors 有权
    取代的萘啶和喹啉化合物作为MAO抑制剂

    公开(公告)号：US09102674B2

    公开(公告)日：2015-08-11

    申请号：US14204738

    申请日：2014-03-11

    Applicant: DART NEUROSCIENCE (CAYMAN) LTD.

    Inventor： Jillian Basinger ,  Graeme Freestone ,  Varsha Gupta ,  Alan Kaplan ,  Chi-Ching Mak ,  Benjamin Pratt ,  Vincent Santora ,  Dipanjan Sengupta ,  Lino Valdez

    IPC: C07D215/54 ,  C07D471/04 ,  C07D215/60 ,  C07D401/12

    CPC classification number: A61K31/47 ,  A61K31/4375 ,  A61K31/4709 ,  C07D215/20 ,  C07D215/22 ,  C07D215/54 ,  C07D215/60 ,  C07D401/12 ,  C07D471/04

    Abstract: The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, Y, and n have any of the values described herein and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting MAO, and MAO-B selectively, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders (including obesity, diabetes, and cardiometabolic disorders) and their associated co-morbidities.

    Abstract translation: 本发明提供式（I）的化学实体，其中R 1，R 2，R 3，Y和n具有本文所述的任何值和包含这些化学实体的组合物; 制作方法; 并在广泛的方法中使用，包括代谢和反应动力学研究，检测和成像技术以及放射性治疗; 选择性地抑制MAO和MAO-B的治疗，增强神经元可塑性，治疗神经障碍，提供神经保护，治疗与CNS病症相关的认知障碍，提高认知和运动训练的效率，提供神经复发和神经康复，增强 非人类动物训练方案的效率以及治疗周围疾病（包括肥胖，糖尿病和心脏代谢紊乱）及其相关并发症。

    SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS
    3.
    发明申请
    SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS 有权
    取代的萘啶和喹啉化合物作为MAO抑制剂

    公开(公告)号：US20160074377A1

    公开(公告)日：2016-03-17

    申请号：US14862874

    申请日：2015-09-23

    Applicant: DART NEUROSCIENCE (CAYMAN) LTD.

    Inventor： Jillian Basinger ,  Graeme Freestone ,  Varsha Gupta ,  Alan Kaplan ,  Chi-Ching Mak ,  Benjamin Pratt ,  Vincent Santora ,  Dipanjan Sengupta ,  Lino Valdez

    IPC: A61K31/47 ,  A61K31/4375 ,  A61K31/4709

    CPC classification number: A61K31/47 ,  A61K31/4375 ,  A61K31/4709 ,  C07D215/20 ,  C07D215/22 ,  C07D215/54 ,  C07D215/60 ,  C07D401/12 ,  C07D471/04

    Abstract: The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, Y, and n have any of the values described herein and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting MAO, and MAO-B selectively, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating treating peripheral disorders (including obesity, diabetes, and cardiometabolic disorders) and their associated co-morbidities.

    Abstract translation: 本发明提供式（I）的化学实体，其中R 1，R 2，R 3，Y和n具有本文所述的任何值和包含这些化学实体的组合物; 制作方法; 并在广泛的方法中使用，包括代谢和反应动力学研究，检测和成像技术以及放射性治疗; 选择性地抑制MAO和MAO-B的治疗，增强神经元可塑性，治疗神经障碍，提供神经保护，治疗与CNS病症相关的认知障碍，提高认知和运动训练的效率，提供神经复发和神经康复，增强 非人类动物训练方案的效率以及治疗外周疾病（包括肥胖，糖尿病和心脏代谢障碍）及其相关并发症的治疗。

    Substituted naphthyridine and quinoline compounds as MAO inhibitors
    6.
    发明授权
    Substituted naphthyridine and quinoline compounds as MAO inhibitors 有权
    取代的萘啶和喹啉化合物作为MAO抑制剂

    公开(公告)号：US09150572B2

    公开(公告)日：2015-10-06

    申请号：US14205195

    申请日：2014-03-11

    Applicant: DART NEUROSCIENCE (CAYMAN) LTD.

    Inventor： Jillian Basinger ,  Graeme Freestone ,  Varsha Gupta ,  Alan Kaplan ,  Chi-Ching Mak ,  Benjamin Pratt ,  Vincent Santora ,  Dipanjan Sengupta ,  Lino Valdez

    IPC: C07D471/02 ,  C07D215/00 ,  C07D471/04 ,  C07D215/54

    CPC classification number: A61K31/47 ,  A61K31/4375 ,  A61K31/4709 ,  C07D215/20 ,  C07D215/22 ,  C07D215/54 ,  C07D215/60 ,  C07D401/12 ,  C07D471/04

    Abstract: The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, Y, and n have any of the values described herein and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting MAO, and MAO-B selectively, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating treating peripheral disorders (including obesity, diabetes, and cardiometabolic disorders) and their associated co-morbidities.

    Abstract translation: 本发明提供式（I）的化学实体，其中R 1，R 2，R 3，Y和n具有本文所述的任何值和包含这些化学实体的组合物; 制作方法; 并在广泛的方法中使用，包括代谢和反应动力学研究，检测和成像技术以及放射性治疗; 选择性地抑制MAO和MAO-B的治疗，增强神经元可塑性，治疗神经障碍，提供神经保护，治疗与CNS病症相关的认知障碍，提高认知和运动训练的效率，提供神经复发和神经康复，增强 非人类动物训练方案的效率以及治疗外周疾病（包括肥胖，糖尿病和心脏代谢障碍）及其相关并发症的治疗。

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