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公开(公告)号：US09950984B2
公开(公告)日：2018-04-24
申请号：US15614875
申请日：2017-06-06
发明人： Akihiro Gotou , Manaho Miyazaki , Sumi Ishihara , Takashi Namikawa , Tatsuya Ohtsuka , Yosuke Kishikawa
IPC分类号： C07C67/36
CPC分类号： C07C67/36 , C07C69/653 , C07C69/65
摘要： An object of the present invention is to provide a process for producing α-fluoroacrylic acid esters at a high starting material conversion and a high yield. The present invention provides, as a means to achieve the object, a process for producing a compound represented by formula (1): wherein R1 and R2 are the same or different and each represent alkyl, fluoroalkyl, aryl optionally substituted with at least one substituent, halogen, or hydrogen; and R3 represents alkyl, fluoroalkyl, or aryl optionally substituted with at least one substituent, the process comprising step A of reacting a compound represented by formula (2): wherein the symbols are as defined above, with carbon monoxide and an alcohol represented by formula (3): R3—OH (3) wherein the symbol is as defined above, in the presence of a transition metal complex catalyst containing at least one bidentate phosphine ligand and a base to thereby obtain the compound represented by formula (1).
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公开(公告)号：US09701614B2
公开(公告)日：2017-07-11
申请号：US15107204
申请日：2014-12-26
发明人： Akihiro Gotou , Manaho Miyazaki , Sumi Ishihara , Takashi Namikawa , Tatsuya Ohtsuka , Yosuke Kishikawa
IPC分类号： C07C67/36
摘要： An object of the present invention is to provide a process for producing α-fluoroacrylic acid esters at a high starting material conversion and a high yield. The present invention provides, as a means to achieve the object, a process for producing a compound represented by formula (1): wherein R1 and R2 are the same or different and each represent alkyl, fluoroalkyl, aryl optionally substituted with at least one substituent, halogen, or hydrogen; and R3 represents alkyl, fluoroalkyl, or aryl optionally substituted with at least one substituent, the process comprising step A of reacting a compound represented by formula (2): wherein the symbols are as defined above, with carbon monoxide and an alcohol represented by formula (3): R3—OH (3) wherein the symbol is as defined above, in the presence of a transition metal complex catalyst containing at least one bidentate phosphine ligand and a base to thereby obtain the compound represented by formula (1).
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公开(公告)号：US10173960B2
公开(公告)日：2019-01-08
申请号：US15564927
申请日：2016-04-08
发明人： Tomohito Hamada , Makoto Matsuura , Asako Yoshiyama , Akihiro Gotou , Manaho Miyazaki , Yosuke Kishikawa
IPC分类号： C07C47/02 , C07C67/62 , C07C69/653
摘要： An object of the present invention is to provide a method for stabilizing an acrylic acid derivative, and a composition containing an acrylic acid derivative in which the acrylic acid derivative is stabilized. The present invention provides a composition comprising: (A) an acrylic acid derivative represented by Formula (I): (wherein Ra represents alkyl, fluoroalkyl, aryl that may have one or more substituents, or hydrogen; and X represents fluorine, alkyl, perfluoroalkyl, or hydrogen); and (B) aldehyde, wherein the content of acrylic acid derivative (A) is 30% (w/w) or more.
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公开(公告)号：US09732027B2
公开(公告)日：2017-08-15
申请号：US15107204
申请日：2014-12-26
发明人： Akihiro Gotou , Manaho Miyazaki , Sumi Ishihara , Takashi Namikawa , Tatsuya Ohtsuka , Yosuke Kishikawa
IPC分类号： C07C67/36
CPC分类号： C07C67/36 , C07C69/653 , C07C69/65
摘要： An object of the present invention is to provide a process for producing α-fluoroacrylic acid esters at a high starting material conversion and a high yield. The present invention provides, as a means to achieve the object, a process for producing a compound represented by formula (1): wherein R1 and R2 are the same or different and each represent alkyl, fluoroalkyl, aryl optionally substituted with at least one substituent, halogen, or hydrogen; and R3 represents alkyl, fluoroalkyl, or aryl optionally substituted with at least one substituent, the process comprising step A of reacting a compound represented by formula (2): wherein the symbols are as defined above, with carbon monoxide and an alcohol represented by formula (3): R3—OH (3) wherein the symbol is as defined above, in the presence of a transition metal complex catalyst containing at least one bidentate phosphine ligand and a base to thereby obtain the compound represented by formula (1).
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