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公开(公告)号:US20020141631A1
公开(公告)日:2002-10-03
申请号:US09792012
申请日:2001-02-20
申请人: Cytokinetics, Inc.
发明人: Eugeni A. Vaisberg , Ge Cong , Hsien-Hsun Wu
IPC分类号: G06K009/00 , G06K009/62 , G06K009/42 , G06K009/44
CPC分类号: G06K9/0014 , G01N15/1475 , G01N2015/1006 , G01N2015/1472 , G01N2015/149 , G06K9/00127
摘要: Methods, code and apparatus analyze cell images to automatically identify and characterize the Golgi complex in individual cells. This is accomplished by first locating the cells in the image and defining boundaries of those cells that subsume some or all of the Golgi complex of those cells. The Golgi complex in the images typically have intensity values corresponding to the concentration of a Golgi component in the cell (e.g. a polysaccharide associated with the Golgi complex). The method/system then analyzes the Golgi components of the image (typically on a pixel-by-pixel basis) to mathematically characterize the Golgi complex of individual cells. This mathematical characterization represents phenotypic information about the cells' Golgi complex and can be used to classify cells. From this information, mechanism of action and other important biological information can be deduced.
摘要翻译: 方法,代码和设备分析细胞图像,以自动识别和表征单个细胞中的高尔基复合体。 这是通过首先将细胞定位在图像中并定义包含这些细胞的一些或所有高尔基复合体的那些细胞的边界来实现的。 图像中的高尔基复合体通常具有对应于细胞中高尔基成分浓度的强度值(例如与高尔基复合体相关的多糖)。 该方法/系统然后分析图像的高尔基分量(通常在逐个像素的基础上)来数学地表征单个细胞的高尔基复合体。 该数学表征表示关于细胞的高尔基复合物的表型信息,并且可以用于细胞分类。 从这些信息可以推断出作用机制和其他重要的生物信息。